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Chlorpromazine

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Definition: The prototypical phenothiazine antipsychotic drug. Like the other drugs in this class chlorpromazine's antipsychotic actions are thought to be due to long-term adaptation by the brain to blocking DOPAMINE RECEPTORS. Chlorpromazine has several other actions and therapeutic uses, including as an antiemetic and in the treatment of intractable hiccup.     
Pharmacological Action Antiemetics; Antipsychotic Agents; Dopamine Antagonists 		Other names Hydrochloride, Chlorpromazine; Thorazine; Propaphenin; Largactil; Fenactil; Contomin; Chlorpromazine Hydrochloride; Chlordelazine; Chlorazine; AminazineDrugs* : SONAZINE; THORAZINE; CHLORPROMAZINE HYDROCHLORIDE; PROMAPAR; CHLORPROMAZINE HYDROCHLORIDE INTENSOL
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
vegetamin  0   *Chlorpromazine *Phenobarbital Drug Combinations. Leg Med (Tokyo) 2006 May;8(3):172-6
SK&F 2133-A  150260-98-3   Chlorpromazine/*analogs & derivatives. Am J Trop Med Hyg 1993 Jan;48(1):126-33
sodium lactobionate sucrose solution  0   Chlorpromazine Sucrose Solutions. Transplant Proc 1991;23(1):660
N-benzoyloxymethylchlorpromazine  76637-14-4   Chlorpromazine/*analogs & derivatives. J Neurochem 1988;50(1):138
N-pivaloyloxymethylchlorpromazine  113611-35-1   Chlorpromazine/*analogs & derivatives. J Neurochem 1988;50(1):138
chlorproethazine  84-01-5   Chlorpromazine/*analogs & derivatives.
Pharma Action Muscle Relaxants, Central 		J Chromatogr 1987;419:363
calmodulin-chlorpromazine complex  0   *Calmodulin Chlorpromazine/*analogs & derivatives Calcium-Transporting ATPases/antagonists & inhibitors. J Pharmacol Exp Ther 1987;243(1):171
chlorpromazine, dexamethasone, metoclopramide, orphenadrine drug combination  0   *Chlorpromazine *Dexamethasone *Metoclopramide *Orphenadrine Drug Combinations. Cancer Chemother Pharmacol 1986;18(1):88
chlorpromazine N-oxide  1672-76-0   Chlorpromazine/*analogs & derivatives. Ther Drug Monit 1985;7(2):222
7,8-dioxo-N,N-didesmethylchlorpromazine  95574-31-5   Chlorpromazine/*analogs & derivatives Adenylate Cyclase/antagonists & inhibitors. Arch Int Pharmacodyn Ther 1985;273(2):202
7,8-dihydroxy-N,N-didesmethylchlorpromazine  95574-30-4   Chlorpromazine/*analogs & derivatives Adenylate Cyclase/antagonists & inhibitors. Arch Int Pharmacodyn Ther 1985;273(2):202
norchlorpromazine-calmodulin complex  0   *Calmodulin Chlorpromazine/*analogs & derivatives. FEBS Lett 1984;165(2):269
norchlorpromazine isothiocyanate  87508-98-3   Chlorpromazine/*analogs & derivatives. Biochemistry 1983;22(24):5472
Kominek's mixture  81424-60-4 Benzoic acid, 2-(acetyloxy)-, mixt. with 2-chloro-N,N-dimethyl-10H-phenothiazine-10-propanamine, 5-ethyl-5-phenyl-2,4,6(1H,3H,5H)-pyrimidinetrione, 2-methyl-2-propyl-1,3-propanediyl dicarbamate and N,N,alpha-trimethyl-10H-phenothiazone-10-ethanamine mono  *Aspirin *Chlorpromazine *Meprobamate *Phenobarbital *Promethazine Drug Combinations. Stomalologiia (Mosk) 1981;60(6):24
8-hydroxychlorpromazine  3926-67-8   Chlorpromazine/*analogs & derivatives. Eur J Pharmacol 1981;75(2-3):137
norchlorpromazine  1225-64-5   Chlorpromazine/*analogs & derivatives. Psychopharmacology 1981;73(1):55
7,8-dihydroxychlorpromazine  21598-02-7   Chlorpromazine/*analogs & derivatives. Circ Res 1981;48(3):378
opromazine  969-99-3   Chlorpromazine/*analogs & derivatives. Acta Microbiol Acad Sci Hung 1980;27(1):55
7,8-dioxochlorpromazine  52172-18-6   Chlorpromazine/*analogs & derivatives. Acta Microbiol Acad Sci Hung 1980;27(1):55
didemethylchlorpromazine  2095-17-2 2-chloro-10H-phenothazine-10-propanamine  Chlorpromazine/*analogs & derivatives. Drug Metab Dispos 7(6):404;1979
didemethylchlorpromazine sulfoxide  2232-49-7 2-chloro-10H-phenothiazine-10-propanamine 5-oxide  Chlorpromazine/*analogs & derivatives. Drug Metab Dispos 7(6):404;1979
didemethylchlorpromazine sulfone  67291-47-8 2-chloro-10H-phenothiazine-10-propanamine 5,5-dioxide  Chlorpromazine/*analogs & derivatives. Drug Metab Dispos 7(6):404;1979
chlorpromazine undecahydrododecaborate  60385-85-5   Chlorpromazine/*analogs & derivatives. Chem Pharm Bull 24(4):778;1976
chlorpromazine nonahydrodecaborate  60385-84-4   Chlorpromazine/*analogs & derivatives. Chem Pharm Bull 24(4):778;1976
methochlorpromazine  19077-31-7   Chlorpromazine/*analogs & derivatives. Proc Nat Acad Sci USA 71(11):4457;1974
7-hydroxychlorpromazine  2095-62-7 8-chloro-10-(3-(dimethylamino)propyl)-10H- phenothiazin-3-ol  Chlorpromazine/*analogs & derivatives. Drug Addict Vol 3: Neurobiol Influence Behav W3 IN197kc:81;1973d; Int J Radiat Oncol Biol Phys 4(9-10):821;1978; Toxicol Appl Pharmacol 28(1):8;1974
chlorfenethazine  2095-24-1 2-chloro-10-(beta-dimethylaminoethyl)phenothiazine  Chlorpromazine/*analogs & derivatives. Kinderaerztl Prax 41(1):17;1973

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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