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Cholera Toxin

More information in Books or onNLM PubMed
Definition: An ENTEROTOXIN from VIBRIO CHOLERAE. It consists of two major protomers, the heavy (H) or A subunit and the B protomer which consists of 5 light (L) or B subunits. The catalytic A subunit is proteolytically cleaved into fragments A1 and A2. The A1 fragment is a MONO(ADP-RIBOSE) TRANSFERASE. The B protomer binds cholera toxin to intestinal epithelial cells, and facilitates the uptake of the A1 fragment. The A1 catalyzed transfer of ADP-RIBOSE to the alpha subunits of heterotrimeric G PROTEINS activates the production of CYCLIC AMP. Increased levels of cyclic AMP are thought to modulate release of fluid and electrolytes from intestinal crypt cells.  /antag permitted but consider also ANTITOXINS   
Pharmacological Action Adjuvants, Immunologic; Poisons 		Other names Choleragenoid; Choleragen; Cholera Toxin Protomer B; Cholera Toxin Protomer A; Toxin, Cholera; Exotoxin, Cholera; Enterotoxin CT, Cholera; CT, Cholera Enterotoxin; Procholeragenoid; Cholera Toxin B Subunit; Cholera Toxin A Subunit; Cholera Exotoxin; Cholera Enterotoxin CT
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
CTA1R7K-COL-DD  0   *Cholera Toxin *Recombinant Fusion Proteins Peptide Fragments. Arthritis Rheum. 2009 Jun;60(6):1672-82
CTB-Gag fusion protein, recombinant  0   *Recombinant Fusion Proteins Cholera Toxin Gene Products, gag. Mol Biotechnol 2004 Sep;28(1):33-40
cholera holotoxin, His(29)  EC 2.4.2.31   *Cholera Toxin. Vaccine 2003 Jan 17;21(5-6):376-85
cholera toxin B-immunodominant peptide conjugate (234-246)  0   *Antigens, Helminth *Cholera Toxin *Peptide Fragments. Parasite Immunol 2002 Aug;24(8):423-7
CTA1-DD protein, recombinant  0   *Cholera Toxin *Recombinant Fusion Proteins. J Immunol 2001 Sep 15;167(6):3398-405
cholera toxin B-saporin conjugate  0   *Cholera Toxin *Ribosome Inactivating Proteins, Type 1. J Neurosci 2000 Dec 15;20(24):9215-23
zonulin  0   *Cholera Toxin. Lancet 2000 Apr 29;355(9214):1518-9
EpsD protein, Vibrio cholerae  0   *Bacterial Proteins *Cholera Toxin. Infect Immun 2000 Apr;68(4):1967-74
cholera toxin B-insulin conjugate  0   *Cholera Toxin *Insulin Vaccines, Conjugate. Diabetes 1999 Nov;48(11):2150-6
cholera toxin B subunit (50-75)  0   *Cholera Toxin *Peptide Fragments. Vaccine 1993 Sep;11(12):1233-40
Ace toxin  0   *Cholera Toxin Adenosine Triphosphatases. Proc Natl Acad Sci U S A 1993 Jun 1;90(11):5267-71
zonula occludens toxin, Vibrio cholerae  146481-28-9   *Cholera Toxin Adenosine Triphosphatases. FEBS Lett 1992 Nov 2;312(1):3-6
E coli O18 O-specific polysaccharide-cholera toxin  0   *Antigens, Bacterial *Cholera Toxin *Cholera Vaccines Escherichia coli. J Infect Dis 1991;163(5):1040
N-acetyl-cholera toxin (50-64)-3-amide  132177-90-3   *Cholera Toxin *Peptide Fragments. Biochemistry 1990;29(4):887
human chorionic gonadotropin-cholera toxoid conjugate  0   *Cholera Toxin *Chorionic Gonadotropin *Luteinizing Hormone Vaccines, Conjugate. Vaccine 1989;7(2):129
cholera toxin, B subunit-horseradish peroxidase  0   *Cholera Toxin *Horseradish Peroxidase. Exp Neurol 1987;96(3):621
cholera toxin, B subunit (50-64)  89157-28-8   *Cholera Toxin *Peptide Fragments. Immunology 1986;59(1):129
cholera toxoid  0   *Cholera Toxin *Toxoids Vibrio cholerae. J Clin Lab Immunol 1983;11(1):37
hybrid toxin, diphtheria-cholera  0   *Cholera Toxin *Diphtheria Toxin. Biochim Biophys Acta 1980;626(2):443
choleragen receptor  0   *G(M1) Ganglioside *Receptors, Cell Surface Cholera Toxin. J Biol Chem 1980;255(6):2549

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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