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Choline Kinase

More information in Books or onNLM PubMed
Definition: An enzyme that is active in the first step of choline phosphoglyceride (lecithin) biosynthesis by catalyzing the phosphorylation of choline to phosphorylcholine in the presence of ATP. Ethanolamine and its methyl and ethyl derivatives can also act as acceptors. EC 2.7.1.32.      Other names ATP Choline Transphosphatase; Transphosphatase, ATP Choline; Phosphokinase, Choline; Kinase, Choline; Choline Transphosphatase, ATP; Choline Phosphokinase
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
N-(3,5-dimethylphenyl)-2-((5-(4-ethylphenyl)-1H-1,2,4-triazol-3-yl)sulfanyl)acetamide  0   *Acetamides *Triazoles Choline Kinase/antagonists & inhibitors. Oncogene 2011 Jul 28;30(30):3370-80
CHKB protein, human  EC 2.7.1.32   *Choline Kinase. PLoS One. 2009;4(4) (dup#18):e5394
choline kinase alpha, mouse  EC 2.7.1.32   *Choline Kinase. J Biol Chem 2008 Jan 18;283(3):1456-62
CHKA protein, human  EC 2.7.1.32   *Choline Kinase. BMC Med 2006;4:36
1,1'-(ethylenebis(benzene-1,4-diylmethylene))bis(7-chloro-4-(pyrrolidino)quinolinium)  0   *Quinolinium Compounds Choline Kinase/antagonists & inhibitors. J Med Chem 2005 May 5;48(9):3354-63

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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