encyclopedia of medical concepts
ψ 
ψ 
ψ 

Cholinesterase Inhibitors

More information in Books or onNLM PubMed
Definition: Drugs that inhibit cholinesterases. The neurotransmitter ACETYLCHOLINE is rapidly hydrolyzed, and thereby inactivated, by cholinesterases. When cholinesterases are inhibited, the action of endogenously released acetylcholine at cholinergic synapses is potentiated. Cholinesterase inhibitors are widely used clinically for their potentiation of cholinergic inputs to the gastrointestinal tract and urinary bladder, the eye, and skeletal muscles; they are also used for their effects on the heart and the central nervous system.  DF: CHOLINESTERASE INHIB   
See Also Insecticides 		Other names Anticholinesterase Agents; Acetylcholinesterase Inhibitors; Reversible Cholinesterase Inhibitors; Irreversible Cholinesterase Inhibitors; Inhibitors, Reversible Cholinesterase; Inhibitors, Irreversible Cholinesterase; Inhibitors, Cholinesterase; Inhibitors, Acetylcholinesterase; Drugs, Anticholinesterase; Anti Cholinesterases; Agents, Anticholinesterase; Cholinesterase Inhibitors, Reversible; Cholinesterase Inhibitors, Irreversible; Anticholinesterases; Anticholinesterase Drugs; Anti-Cholinesterases
Substances having this pharmacologic action: 1,10-phenanthroline; octamethyl pyrophosphoramide; methanesulfonyl fluoride; alternariol; tabun; VX; normeperidine; phosalone; phoxim; donepezil; Phorate; Diazinon; Phosphamidon; Physostigmine; Dichlorvos; Armin; Chlorfenvinphos; Propoxur; Ambenonium Chloride; Aldicarb; Azinphosmethyl; Naled; Neostigmine; Carbaryl; Soman; Pyridostigmine Bromide; Sarin; Tacrine; Tetrachlorvinphos; Tetraisopropylpyrophosphamide; Trichlorfon; Paraoxon; Parathion; Malathion; Methomyl; Methyl Parathion; Galantamine; Dimethoate; Coumaphos; Chlorpyrifos; Fonofos; Echothiophate Iodide; Edrophonium; Phenylphosphonothioic Acid, 2-Ethyl 2-(4-Nitrophenyl) Ester; Mevinphos; Monocrotophos; Carbofuran; Fenthion; Isoflurophate; Fenitrothion; 2,5-hexanedione; demecarium bromide; distigmine; rivastigmine; velnacrine; huperzine A; physostigmine heptyl; N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine; fasciculin
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
4-(3-ethylthiophenyl)-2-(3-thienyl)-1H-imidazole  0   *Imidazoles *Thiophenes Cholinesterase Inhibitors. Eur J Pharm Sci. 2012 Jan 23;45(1-2):169-83
6-hydroxy-4-oxo-N-(10-((1,2,3,4-tetrahydroacridin-9-yl)amino)decyl)-4H-chromene-2-carboxamide  0   *Chromones Tacrine/*analogs & derivatives Butyrylcholinesterase Cholinesterase Inhibitors Amyloid Precursor Protein Secretases/antagonists & inhibitors. J Med Chem. 2012 Feb 9;55(3):1303-17.
N-((5-(3-(1-benzylpiperidin-4-yl)propoxy)-1-methyl-1H-indol-2-yl)methyl)-N-methylprop-2-yn-1-amine  0   *Indoles *Piperidines Butyrylcholinesterase Cholinesterase Inhibitors Monoamine Oxidase Inhibitors. J Med Chem. 2011 Dec 22;54(24):8251-70.
narciprimine  0   *Phenanthrenes *Amaryllidaceae Alkaloids Cholinesterase Inhibitors. J Ethnopharmacol. 2011 Oct 11;137(3):1102-6
1-(4-(benzo(d)(1,3)dioxol-5-ylmethyl)piperazin-1-yl)-5-(1,2-dithiolan-3-yl)pentan-1-one  0   *Piperazines *Thiophenes Thioctic Acid/*analogs & derivatives Cholinesterase Inhibitors. Neurochem Int. 2011 Oct;59(5):722-8
4-methyl-N-(4-(8,9,10,11-tetrahydro-6H-azocino(2,1-b)quinazolin-13(7H)-ylideneamino)butyl)-N-(3-(8,9,10,11-tetrahydro-6H-azocino(2,1-b)quinazolin-13(7H)-ylideneamino)propyl)pentanamide  0   *Quinazolines Butyrylcholinesterase Cholinesterase Inhibitors. Bioorg Med Chem 2011 Feb 1;19(3):1222-35
4-(13-amino-10,11,12,14-tetrahydro-9H-benzo(5,6)chromeno(2,3-b)quinolin-14-yl)phenol  0   *Aminoquinolines *Benzopyrans Cholinesterase Inhibitors. Bioorg Med Chem Lett 2011 Apr 15;21(8):2384-8
4-(4-ethyl-piperazin-1-yl)-1-(2,3,4-trihydroxyphenyl)butan-1-one  0   *Piperazines Gallic Acid/*analogs & derivatives Cholinesterase Inhibitors Receptors, sigma/antagonists & inhibitors. Med Chem 2010 May 1;6(3):123-40
dimethyl-carbamic acid 2,3-bis-dimethylcarbamoyloxy-6-(4-ethylpiperazine-1-carbonyl)phenyl ester  0   *Carbamates *Piperazines Cholinesterase Inhibitors Receptors, sigma/antagonists & inhibitors. Med Chem 2010 May 1;6(3):123-40
mesuagenin B  0   *Coumarins Cholinesterase Inhibitors. Bioorg Med Chem 2010 Nov 15;18(22):7873-7
1,2,3,4-tetrahydro-N-(3-iodophenyl-methyl)-9-acridinamine  0   *Aminoacridines Cholinesterase Inhibitors. Protein Sci 2000 Jun;9(6):1063-72
1,2,3,4-tetrahydro-N-(phenyl-methyl)-9-acridinamine  0   *Aminoacridines Cholinesterase Inhibitors. Protein Sci 2000 Jun;9(6):1063-72
atramine  0   *Proteins Cholinesterase Inhibitors. Biochim Biophys Acta 1980;623(2):354

To share this definition, click "text" (Facebook, Twitter) or "link" (blog, mail) then paste text link
Ads by Google

Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
Warning: the drugs or drug combinations referred to here may be similar or related, but are not be the same ones and may not have the same pharmacological action as other substances described on the same page or in the same row. Please refer to product monograph or to your doctor
This website is accredited by Health On the Net Foundation. Click to verify. We comply with the HONcode standard for trustworthy health information: verify here.
About Reference.MD Privacy