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Chymotrypsin

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Definition: A serine endopeptidase secreted by the pancreas as its zymogen, CHYMOTRYPSINOGEN and carried in the pancreatic juice to the duodenum where it is activated by TRYPSIN. It selectively cleaves aromatic amino acids on the carboxyl side.  /antag: consider also ALPHA 1-ANTICHYMOTRYPSIN    Other names Wampole Brand of Chymotrypsin; Sanofi Synthelabo Brand of Chymotrypsin; Leurquin Brand of Chymotrypsin; Delalande Brand of Chymotrypsin; Avazyme; Alphacutan+¬e; Alpha-Chymotrypsin ChoayDrugs* : ZOLYSE; ALPHA CHYMAR; CATARASE
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
elaeagnoside  0   *Saponins Chymotrypsin/antagonists & inhibitors. Nat Prod Res 2009;23(5):409-14
stachyrase A  EC 3.4.21.-   *Serine Endopeptidases Chymotrypsin. Infect Immun 2002 Jan;70(1):419-21
AMCI-1 protein, Apis mellifera  0   *Blood Proteins *Insect Proteins Chymotrypsin/antagonists & inhibitors. Protein Sci 2000 May;9(5):976-84
ChyL protease, Anopheles  EC 3.4.21.-   *Serine Endopeptidases *Insect Proteins Chymotrypsin. Insect Mol Biol 2000 Jun;9(3):223-9
CEI protein, Trichuris suis  0   *Proteins Chymotrypsin/antagonists & inhibitors Pancreatic Elastase/antagonists & inhibitors. Exp Parasitol 2000 May;95(1):36-44
chymotrypsin B  EC 3.4.21.1   *Chymotrypsin.
alpha-chymotrypsin  EC 3.4.21.-   *Chymotrypsin.
gamma-chymotrypsin  EC 3.4.21.-   *Chymotrypsin.
chymotrypsin C  EC 3.4.21.2   *Chymotrypsin.
chymocell  0   *Cellulose *Chymotrypsin. Sb Lek 1997;98(3):209-11
methyl 2-allyl-3-benzenepropanoate  0   *Allyl Compounds *Phenylpropionates Chymotrypsin/antagonists & inhibitors. Bioorg Med Chem 1998 Feb;6(2):239-49
cytin protein, Thereomyzon tessulatum  0   *Proteins Chymotrypsin/antagonists & inhibitors. Eur J Biochem 1997 Nov 1;249(3):733-8
2,2-dimethyl-3-(N-4-cyanobenzoyl)amino-5-phenyl pentanoic anhydride  0   *Anhydrides *Benzamides Chymotrypsin/antagonists & inhibitors. Biochem Biophys Res Commun 1997 Nov 26;240(3):850-5
dentilisin  EC 3.4.21.-   *Chymotrypsin. Infect Immun 1996 Dec;64(12):5178-86
benzyloxycarbonylphenylalanylglyoxal  0   Glyoxal/*analogs & derivatives Phenylalanine/*analogs & derivatives Chymotrypsin/antagonists & inhibitors. Biochem Soc Trans 1996 Feb;24(1):129S
Uca pugilator serine collagenase 1  EC 3.4.21.32   *Chymotrypsin Recombinant Proteins Collagenases. J Biol Chem 1996 May 10;271(19):11563-70
chymotrypsinogen C  0   *Chymotrypsinogen *Serine Endopeptidases Chymotrypsin. EMBO J 1995 Sep 15;14(18):4387-94
chymotrypsin inhibitor 2  0   *Peptides *Plant Proteins Chymotrypsin/antagonists & inhibitors.
Pharma Action Serine Proteinase Inhibitors 		Proc Natl Acad Sci U S A 1995 Apr 25;92(9):3683-6
Lucilia chymotrypsin b  EC 3.4.21.-   *Chymotrypsin. Insect Mol Biol 1994 Nov;3(4):201-11
N-nitroso-N-((6-methoxyquinolin-2-yl)methyl)-N'-isobutyrylalaninamide  0   *Nitrosamines Chymotrypsin/antagonists & inhibitors. Bioconjug Chem 1994 Sep-Oct;5(5):454-8
N-nitroso-N-((7-methoxycoumarin-4-yl)methyl)-N'-isobutyrylalaninamide  0   *Nitrosamines Chymotrypsin/antagonists & inhibitors. Bioconjug Chem 1994 Sep-Oct;5(5):454-8
alpha2-macroglobulin-chymotrypsin  0   *alpha-Macroglobulins *Chymotrypsin. Ann N Y Acad Sci 1994 Sep 10;737:439-43
chymotrypsin, tosyl  0   *Chymotrypsin. Biochim Biophys Acta 1994 Sep 21;1208(1):171-8
chymotrypsin, N-methylHis(57)  0   *Chymotrypsin. Biochemistry 1994 Aug 16;33(32):9784-90
chymotrypsin inhibitor protein, Hordeum vulgare  0   *Plant Proteins Chymotrypsin/antagonists & inhibitors. Biochim Biophys Acta 1994 Jun 30;1222(2):179-86
2-propyl methylphosphonochloridate  1445-76-7   *Organophosphorus Compounds Chymotrypsin/antagonists & inhibitors. Chirality 1993;5(3):143-9
4-nitrophenyl 2-propylmethylphosphonate  3735-97-5   *Phosphonic Acids Chymotrypsin/antagonists & inhibitors. Chirality 1993;5(3):143-9
PVI-3(2) protein, Phaseolus vulgaris  0   *Plant Proteins Chymotrypsin/antagonists & inhibitors. Z Lebensm Unters Forsch 1993 Apr;196(4):343-50
ECI protein, Erythrina variegata  0   *Plant Proteins Chymotrypsin/antagonists & inhibitors. Biosci Biotechnol Biochem 1993 Jan;57(1):102-6
YS 3025  138320-33-9 4-Thiazolidinecarboxylic acid, 3-(1-oxo-2-((2-thienylcarbonyl)thio)propyl)  *Thiophenes *Thiazolidines Chymotrypsin/antagonists & inhibitors. Biochem Int 1992 Nov;28(3):385-92
Locusta migratoria-chymotrypsin inhibitor II  0   *Peptides Chymotrypsin/antagonists & inhibitors. Biochem Biophys Res Commun 1992 Dec 15;189(2):790-3
Locusta migratoria chymotrypsin inhibitor I  0   *Peptides Chymotrypsin/antagonists & inhibitors. Biochem Biophys Res Commun 1992 Dec 15;189(2):790-3
N-benzyloxycarbonyl-leucyl-leucyl-phenylalaninal  143839-79-6   *Oligopeptides Chymotrypsin/antagonists & inhibitors. Biochemistry 1992 Oct 6;31(39):9421-8
(3-(5-methyl-2-thienyl)acryloyl)chymotrypsin  0   *Chymotrypsin *Thiophenes. Biochemistry 1992 Sep 29;31(38):9122-5
carbobenzyloxyleucyl-tyrosine chloromethyl ketone  56979-35-2   *Amino Acid Chloromethyl Ketones Chymotrypsin/antagonists & inhibitors. J Biol Chem 1991;266(24):15870
acetyl-phenylalanyl trifluoromethyl ketone  128656-63-3   Phenylalanine/*analogs & derivatives Chymotrypsin/antagonists & inhibitors. Biochemistry 1990;29(33):7600
phenylalanylphenylalanine methyl ester  13082-29-6   *Dipeptides Chymotrypsin/antagonists & inhibitors. Biochem Biophys Res Commun 1990;166(3):1460
N-acetyl-leucyl-phenylalanyl trifluoromethyl ketone  113215-69-3   *Dipeptides Chymotrypsin/antagonists & inhibitors. Biochemistry 1987;26(24):7603
chymotrypsin beta-benzyme  EC 3.4.21.-   *Chymotrypsin Cyclodextrins. Proc Natl Acad Sci USA 1987;84(3):673
3-benzyl-N-(methanesulfonyloxy)succinimide  106847-87-4   *Succinimides Chymotrypsin/antagonists & inhibitors Pancreatic Elastase/antagonists & inhibitors. Biochem Biophys Res Commun 1986;141(2):741
succinyl-tyrosyl-leucyl-phenylalanine-4-nitroanilide  99242-09-8   *Oligopeptides Chymotrypsin/antagonists & inhibitors. Chem Pharm Bull (Tokyo) 1985;33(12):5301
benzamidomethaneboronic acid  64577-65-7 Boronic acid, ((benzoylamino)methyl)-, (R)  *Boron Compounds Chymotrypsin/antagonists & inhibitors. Arch Biochem Biophys 1984;234(2):531
trypsin, chymotrypsin inhibitor, black-eyed pea  0   Plant Proteins Chymotrypsin/antagonists & inhibitors Trypsin Inhibitors. An Acad Bras Cienc 1983;55(4):409
5-butyl-3H-1,3-oxazine-2,6-dione  89509-90-0 2H-1,3-Oxazine-2,6(3H)-dione, 5-butyl-, (OC-6-11)  *Oxazines Chymotrypsin/antagonists & inhibitors. Biochemistry 1984;23(11):2373
3-benzyl-6-chloro-2-pyrone  85533-80-8 2H-Pyran-2-one, 6-chloro-3-(phenylmethyl)  *Pyrones Chymotrypsin/antagonists & inhibitors. Basic Life Sci 1983;25:301
N-methyl-alpha-chymotrypsin  0   *Chymotrypsin. Biochemistry 1982;21(19):4621
4-(trifluoromethyl)-alpha-bromo-acetanilide  3823-19-6   *Acetanilides Chymotrypsin/antagonists & inhibitors. Biochemistry 1982;21(10):2299
5-bromo-4-oxo-2-phenylhexanoic acid  81214-88-2 Benzeneacetic acid, alpha-(3-bromo-2-oxobutyl)  *Hexanoic Acids Chymotrypsin/antagonists & inhibitors. J Biol Chem 1982;257(2):610
3-bromo-2-buten-2-yl phenylacetate  81214-87-1 Benzeneacetic acid, 2-bromo-1-methyl-1-propenyl ester, (E)  *Phenylacetates Chymotrypsin/antagonists & inhibitors. J Biol Chem 1982;257(2):610
S-methylmethionine-192-alpha-chymotrypsin  0   *Chymotrypsin. J Biol Chem 1981;256(9):4172
p-trifluoromethylbenzenesulfonyl-alpha-chymotrypsin  EC 3.4.21.-   *Chymotrypsin. Can J Biochem 1980;58(5):427
alpha mucase  0   *Chymotrypsin *Glycoside Hydrolases *Multienzyme Complexes. Electrodiagn Ther 11(2):35;1974
phenacyl-alpha-chymotrypsin  EC 3.4.21.-   *Chymotrypsin. Biochem J 171(1):79;1978
proteinase inhibitor I (plants)  37228-81-2 Proteinase inhibitor, potato, I  *Plant Proteins Chymotrypsin/antagonists & inhibitors.
Pharma Action Protease Inhibitors 		J Biochem (Tokyo) 74(4):675;l973; J Biol Chem 1980;255(7):2752
hesperidine methylchalcone, ruscus aculeatus, vitamin C  0   *Ascorbic Acid *Chymotrypsin *Hesperidin *Phytosterols *Trypsin Drug Combinations. Ann Pharm Fr 37(5-6):191;1979
cis-cinnamoylchymotrypsin  EC 3.4.21.-   *Chymotrypsin. Biokhimiia 42(3):465;1977
chymopsin  EC 3.4.-   *Endopeptidases Chymotrypsin. Antibiotiki 18(6):553;1973; Med Radiol (Mosk) 23(6):24;1978; Vestn Khiruraii 120(6):71;1978
diphenylcarbamyl chloride  83-01-2 Carbamic chloride, diphenyl  *Phenylurea Compounds Chymotrypsin/antagonists & inhibitors. J Parasitol 61(5):923;1975
wobe-mugos  60098-82-0   *Chymotrypsin *Papain *Trypsin Drug Combinations. Neoplasma 21(4):465;1974
diisopropylphosphoryl-alpha-chymotrypsin  0   *Chymotrypsin *Organophosphorus Compounds. J Molec Biol 81(3):381;1973
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