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Cisplatin

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Definition: An inorganic and water-soluble platinum complex. After undergoing hydrolysis, it reacts with DNA to produce both intra and interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity of cisplatin correlates with cellular arrest in the G2 phase of the cell cycle.     
Pharmacological Action Antineoplastic Agents; Cross-Linking Reagents; Radiation-Sensitizing Agents 		Other names cis-Dichlorodiammineplatinum(II); cis-Diamminedichloroplatinum(II); Platinum Diamminodichloride; cis Platinum; cis Diamminedichloroplatinum; Diamminodichloride, Platinum; cis-Platinum; cis-Diamminedichloroplatinum; Platinol; Platino; Platidiam; Dichlorodiammineplatinum; Biocisplatinum; NSC-119875Drugs* : PLATINOL-AQ; PLATINOL; CISPLATIN
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
PET regimen  0   *Antineoplastic Combined Chemotherapy Protocols Cisplatin Epirubicin Paclitaxel. Ann Oncol 2009 Jul;20(7):1185-92
DT PACE regimen  0   *Antineoplastic Combined Chemotherapy Protocols Cisplatin Dexamethasone Doxorubicin Etoposide Thalidomide. Blood Coagul Fibrinolysis 2009 Jul;20(5):337-9
NOV 002  0   *Cisplatin *Glutathione Disulfide Drug Combinations. Methods Enzymol 2005;401:287-307
lipoplatin  0   *Cisplatin. Oncol Rep 2005 Apr;13(4):589-95
EDP protocol  0   Cisplatin *Antineoplastic Combined Chemotherapy Protocols Epirubicin Taxoids. Br J Cancer 2004 Jul 5;91(1);18-22
PELF protocol 2  0   *Antineoplastic Combined Chemotherapy Protocols Cisplatin Fluorouracil Glutathione Epirubicin Levoleucovorin. Br J Cancer 2004 Apr 19;90(8):1521-5
SPI-077 B103  0   *Cisplatin. Cancer Chemother Pharmacol 2004 Apr;53(4);329-36
GDP protocol  0   *Antineoplastic Combined Chemotherapy Protocols Cisplatin Deoxycytidine/analogs & derivatives Dexamethasone. Ann Oncol 2003 Dec;14(12):1762-7
TPF protocol  0   *Antineoplastic Combined Chemotherapy Protocols Cisplatin Fluorouracil Taxoids. Br J Cancer. 2004 Jan 26;90(2):348-52
TCF protocol  0   *Antineoplastic Combined Chemotherapy Protocols Cisplatin Fluorouracil Paclitaxel/*analogs & derivatives. Tumori. 2003 Jul-Aug;89(4 Suppl):66
DT-PACE protocol  0   *Antineoplastic Combined Chemotherapy Protocols Cisplatin Cyclophosphamide Dexamethasone Doxorubicin Etoposide Thalidomide. Leuk Lymphoma 2002 Jun;43(6):1267-71
DCEP protocol  0   *Antineoplastic Combined Chemotherapy Protocols Cisplatin Cyclophosphamide Dexamethasone Etoposide Hematopoietic Stem Cell Mobilization. Blood Coagul Fibrinolysis 2002 Apr;13(3):187-92
BOP-CISCA-POMB-ACE regimen  0   *Antineoplastic Combined Chemotherapy Protocols Bleomycin Cisplatin Cyclophosphamide Dactinomycin Doxorubicin Etoposide Methotrexate Vincristine. Br J Cancer 2002 May 20;86(10):1555-60
HLFP regimen  0   *Antineoplastic Combined Chemotherapy Protocols Cisplatin Fluorouracil. Eur J Cancer 2002 Mar;38(5):661-6
opTPFL regimen  0   *Antineoplastic Combined Chemotherapy Protocols Cisplatin Leucovorin Fluorouracil Taxoids. Am J Clin Oncol 2002 Apr;25(2):153-9
ESHAP regimen, modified  0   *Antineoplastic Combined Chemotherapy Protocols Cisplatin Cytarabine Dexamethasone Etoposide. Int J Hematol 2002 Jan 75(1):111-2
CGV protocol  0   *Antineoplastic Combined Chemotherapy Protocols Cisplatin Deoxycytidine/analogs & derivatives Vinblastine/analogs & derivatives. Ann Oncol 2001 Oct;12(10):1369-74
IMAP protocol  0   *Antineoplastic Combined Chemotherapy Protocols Cisplatin Doxorubicin Ifosfamide Mitomycin. Cancer 2002 Feb 1;94(3):786-92
NIACF regimen  0   *Antineoplastic Combined Chemotherapy Protocols Cisplatin Doxorubicin Fluorouracil. Acta Oncol 2001;40(7):855-61
BEMP protocol 2  0   *Antineoplastic Combined Chemotherapy Protocols Bleomycin Cisplatin Vindesine Mitomycin. Ann Oncol 2001 Jul;12(7):967-74
EVAC-G-CSF protocol  0   *Antineoplastic Combined Chemotherapy Protocols Cisplatin Doxorubicin Vinblastine Granulocyte Colony-Stimulating Factor. Am J Clin Oncol 2001 Dec;24(6):551-5
PVP protocol 4  0   *Antineoplastic Combined Chemotherapy Protocols Cisplatin Vinblastine Peplomycin. Gynecol Oncol 2001 Nov;83(2):263-7
PIAF regimen  0   *Antineoplastic Combined Chemotherapy Protocols Cisplatin Doxorubicin Fluorouracil Interferon-alpha. Semin Oncol 2001 Oct;28(5):514-20
FAP2 protocol  0   *Antineoplastic Combined Chemotherapy Protocols Cisplatin Doxorubicin/*analogs & derivatives Fluorouracil. Anticancer Res 2001 May-Jun;21(3C):2149-54
OPEC OJEC protocol  0   *Antineoplastic Combined Chemotherapy Protocols Cisplatin Cyclophosphamide Etoposide Vincristine Carboplatin. Med Pediatr Oncol 2001 Jan;36(1):239-42
poly(ethylene glycol)-poly(cisplatin-aspartic acid)  0   Aspartic Acid/*analogs & derivatives Cisplatin/*analogs & derivatives Polyethylene Glycols. Jpn J Cancer Res 2001 Mar;92(3):328-36
MIFAP regimen  0   *Antineoplastic Combined Chemotherapy Protocols Cisplatin Cytarabine Mitoxantrone Vidarabine/analogs & derivatives. J Cancer Res Clin Oncol 2001;127(6):387-95
Rizzoli IOR protocol  0   *Antineoplastic Combined Chemotherapy Protocols Cisplatin Doxorubicin Ifosfamide Methotrexate. J Chemother 2001 Feb;13(1):93-9
CPT protocol  0   *Antineoplastic Combined Chemotherapy Protocols Cisplatin Topotecan Taxoids. Br J Cancer 2001 May 4;84(9):1166-71
SPI-77, liposomal  0   *Cisplatin. Fresenius J Anal Chem 2000 Feb;366(3):298-302
PP regimen  0   *Antineoplastic Combined Chemotherapy Protocols Cisplatin Carboplatin. Gynecol Obstet Invest 2000;50(4):269-74
PVP protocol 3  0   *Antineoplastic Combined Chemotherapy Protocols Cisplatin Doxorubicin/analogs & derivatives Etoposide. Oncol Rep. 2000 Sep-Oct;7(5):1083-6
BAP protocol 2  0   *Antineoplastic Combined Chemotherapy Protocols Bleomycin Cisplatin Dactinomycin. Oncol Rep. 2000 Nov-Dec;7(6):1235-8
CCC protocol  0   *Antineoplastic Combined Chemotherapy Protocols Cisplatin Cyclophosphamide Carboplatin. Gynecol Oncol 2000 Sep;78(3 Pt 1):361-8
STAMP-I protocol  0   *Antineoplastic Combined Chemotherapy Protocols Carmustine Cisplatin Cyclophosphamide. Bone Marrow Transplant 2000 May;25(10):1047-52
FLUDAP protocol  0   *Antineoplastic Combined Chemotherapy Protocols Vidarabine Phosphate/analogs & derivatives Cisplatin Cytarabine Dexamethasone. Leuk Lymphoma 2000 Apr;37(3-4):309-17
HD-CEP regimen  0   *Antineoplastic Combined Chemotherapy Protocols Cisplatin Cyclophosphamide Etoposide. Oncology 2000 Jun;59(1):7-13
SSG IX protocol  0   *Antineoplastic Combined Chemotherapy Protocols Cisplatin Doxorubicin Ifosfamide Vincristine. Eur J Cancer 2000 May;36(7):875-80
DCM-Dex-CDDP  0   *Cisplatin *Dextrans. Anticancer Drugs 2000 Jan;11(1):33-8
M-FLP protocol  0   *Antineoplastic Combined Chemotherapy Protocols Cisplatin Leucovorin Fluorouracil Methotrexate. Am J Clin Oncol 2000 Jun;23(3):314-8
GIP protocol  0   *Antineoplastic Combined Chemotherapy Protocols Cisplatin Deoxycytidine Ifosfamide. Lung Cancer 2000 May;28(2):109-15
DBPT regimen  0   *Antineoplastic Combined Chemotherapy Protocols Carmustine Cisplatin Dacarbazine Tamoxifen. Br J Cancer 2000 Jun;82(11):1759-63
EEPFL protocol  0   Cisplatin *Antineoplastic Combined Chemotherapy Protocols Leucovorin Etoposide Fluorouracil Epirubicin. Jpn J Clin Oncol 2000 Mar;30(3):122-5
DBCT protocol  0   *Antineoplastic Combined Chemotherapy Protocols Carmustine Cisplatin Dacarbazine Tamoxifen. Br J Cancer 2000 Mar;82(6):1158-62
ViFuP protocol  0   *Antineoplastic Combined Chemotherapy Protocols Cisplatin Fluorouracil Vinblastine/analogs & derivatives. Ann Oncol 2000 Jan;11(1):117-8
Cis-VACD protocol  0   *Antineoplastic Combined Chemotherapy Protocols Cisplatin Cyclophosphamide Dexamethasone Doxorubicin Vindesine. Leuk Lymphoma 1999 Nov;35(5-6):613-8
NaPIM protocol  0   Mesna *Antineoplastic Combined Chemotherapy Protocols Cisplatin Ifosfamide Vinblastine/analogs & derivatives. Cancer Chemother Pharmacol 1999;44 Suppl;S24-5
ECT chemotherapy protocol  0   Cisplatin *Antineoplastic Combined Chemotherapy Protocols Quinazolines Thiophenes Epirubicin. Eur J Cancer 1999 Mar;35 Suppl 1:S14-8
TPFL4 regimen  0   *Antineoplastic Combined Chemotherapy Protocols Cisplatin Leucovorin Fluorouracil Taxoids. J Clin Oncol 1999 Nov;17(11):3503-11
MPEpiV protocol  0   *Antineoplastic Combined Chemotherapy Protocols Cisplatin Leucovorin Methotrexate Vincristine Epirubicin. Breast Cancer Res Treat 1999 Jul;56(2):125-32
MPEpiE protocol  0   *Antineoplastic Combined Chemotherapy Protocols Cisplatin Leucovorin Etoposide Methotrexate Epirubicin. Breast Cancer Res Treat 1999 Jul;56(2):125-32
MPEMi protocol  0   *Antineoplastic Combined Chemotherapy Protocols Cisplatin Leucovorin Etoposide Methotrexate Mitomycin. Breast Cancer Res Treat 1999 Jul;56(2):125-32
FLMP protocol  0   Leucovorin *Antineoplastic Combined Chemotherapy Protocols Cisplatin Fluorouracil Mitomycin. Gan To Kagaku Ryoho 1999 Nov;26(13):2043-8
m-BOP protocol  0   *Antineoplastic Combined Chemotherapy Protocols Bleomycin Cisplatin Ifosfamide Methotrexate Vincristine. Ann Oncol 1999 Jun;10(6):685-92
NIP regimen  0   *Antineoplastic Combined Chemotherapy Protocols Cisplatin Ifosfamide Vinblastine. Acta Oncol 1999;38(5):619-22
PMUE protocol 2  0   *Antineoplastic Combined Chemotherapy Protocols Cisplatin Etoposide Fluorouracil Mitomycin. Gan To Kagaku Ryoho 1999 Apr;26(5):691-5
FCT protocol  0   *Antineoplastic Combined Chemotherapy Protocols Cisplatin Nitrosourea Compounds Tamoxifen. Melanoma Res 1998 Dec;8(6):565-72
GAP protocol  0   *Antineoplastic Combined Chemotherapy Protocols Cisplatin Deoxycytidine/analogs & derivatives Amifostine. Anticancer Drugs 1998 Jul;9(6):511-4
PFLI-alpha protocol  0   *Antineoplastic Combined Chemotherapy Protocols Cisplatin Fluorouracil Interferon-alpha Levoleucovorin. J Clin Oncol 1998 Aug;16(8):2715-21
CAPABLE protocol  0   *Antineoplastic Combined Chemotherapy Protocols Bleomycin Cisplatin Cyclophosphamide Doxorubicin Methotrexate. J Clin Oncol 1998 Jul;16(7):2514-21
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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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