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Clomipramine

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Definition: A tricyclic antidepressant similar to IMIPRAMINE that selectively inhibits the uptake of serotonin in the brain. It is readily absorbed from the gastrointestinal tract and demethylated in the liver to form its primary active metabolite, desmethylclomipramine.     
Pharmacological Action Antidepressive Agents, Tricyclic; Serotonin Uptake Inhibitors 		Other names Chlorimipramine; Monohydrochloride, Clomipramine; Hydrochloride, Clomipramine; Hydiphen; Clomipramine Monohydrochloride; Clomipramine Maleate (1:1); Clomipramine Hydrochloride; Chlomipramine; AnafranilDrugs* : ANAFRANIL; CLOMIPRAMINE HYDROCHLORIDE
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
8-hydroxyclomipramine  83385-97-1 5H-Dibenz(b,f)azepin-1-ol, 7-chloro-5-(3-(dimethylamino)propyl)-10,11-dihydro  Clomipramine/*analogs & derivatives. J Chromatogr 1987;416(2):311
didemethylclomipramine  62724-32-7   Clomipramine/*analogs & derivatives. Boll Soc Ital Biol Sper 1980;56(23):2518
desmethylclomipramine  303-48-0   Clomipramine/*analogs & derivatives. Clin Chem 22(6):817-92;1976; J Chromatogr 142:729;1977; J Int Med Res 5(Suppl 1):108;1977; Postgrad Med J 53(Suppl 4):63;1977; Postgrad Med J 53(Suppl 4):88-139;1977

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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