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Clotrimazole

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Definition: An imidazole derivative with a broad spectrum of antimycotic activity. It inhibits biosynthesis of the sterol ergostol, an important component of fungal CELL MEMBRANES. Its action leads to increased membrane permeability and apparent disruption of enzyme systems bound to the membrane.     
Pharmacological Action 14-alpha Demethylase Inhibitors; Anti-Infective Agents, Local; Antifungal Agents 		Other names Clotrimazole Schering Brand; Schering Brand of Clotrimazole; Mycelex; Lotrimin; Klotrimazole; Kanesten; FB b 5097; Canesten; Bayer Brand 2 of Clotrimazole; Bayer Brand 1 of Clotrimazole; Bay b 5097Drugs* : GYNE-LOTRIMIN 3 COMBINATION PACK; LOTRIMIN AF; TRIVAGIZOLE 3; MYCELEX-7 COMBINATION PACK; GYNE-LOTRIMIN 3; MYCELEX-7; GYNE-LOTRIMIN COMBINATION PACK; GYNIX; CLOTRIMAZOLE; MYCELEX-G; LOTRIMIN; GYNE-LOTRIMIN; MYCELEX
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
1-((4-fluorophenyl)(4-(pyrrolidin-1-ylmethyl)phenyl)(7-chloroquinolin-4-yl)methyl)-1H-imidazole  0   Clotrimazole/*analogs & derivatives. J Med Chem 2008 Mar 13;51(5):1278-94
1-((4-chlorophenyl)bis(4-(pyrrolidin-1-ylmethyl)phenyl)methyl)-1H-imidazole  0   Clotrimazole/*analogs & derivatives. J Med Chem 2008 Mar 13;51(5):1278-94
NC381 agent  0   Clotrimazole/*analogs & derivatives. J Pharmacol Exp Ther. 2004 Feb;308(2):538-46
Lotrisone  0   *Betamethasone *Clotrimazole Drug Combinations. Pediatr Dermatol 2002 Jan-Feb;19(1):78-81LOTRISONE; CLOTRIMAZOLE AND BETAMETHASONE DIPROPIONATE
1-trityl-4-nitroimidazole  0   Clotrimazole/*analogs & derivatives Cytochrome P-450 Enzyme System/antagonists & inhibitors. Acta Crystallogr C 1996 Jan 15;52(Pt 1):189-91
flutrimazole  119006-77-8   Clotrimazole/*analogs & derivatives.
Pharma Action Antifungal Agents 		Arzneimittelforschung 1992 Jun;42(6):832-5
clotrimazole, hydrocortisone drug combination  90155-19-4 Pregn-4-ene-3,20-dione, 11,17,21-trihydroxy-, (11beta)-, mixt. with 1-((2-chlorophenyl)diphenylmethyl)-1H-imidazole  *Clotrimazole *Hydrocortisone Drug Combinations. Med Welt 1983;34(25-26):738
azidamfenicol, clotrimazole drug combination  0   *Clotrimazole Chloramphenicol/*analogs & derivatives Drug Combinations. Med Welt 1982;33(14):525
azidoamphenicol, clotrimazole, dexamethasone drug combination  0   *Clotrimazole *Dexamethasone Chloramphenicol/*analogs & derivatives Drug Combinations. Med Welt 29:1013;1978

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
Warning: the drugs or drug combinations referred to here may be similar or related, but are not be the same ones and may not have the same pharmacological action as other substances described on the same page or in the same row. Please refer to product monograph or to your doctor
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