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Coformycin

More information in Books or onNLM PubMed
Definition: A ribonucleoside antibiotic synergist and adenosine deaminase inhibitor isolated from Nocardia interforma and Streptomyces kaniharaensis. It is proposed as an antineoplastic synergist and immunosuppressant.  an enzyme inhib & antineoplastic antibiotic   
Pharmacological Action Antibiotics, Antineoplastic; Enzyme Inhibitors; Immunosuppressive Agents
Examples Pentostatin
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
carbocyclic coformycin  0   Coformycin/*analogs & derivatives. Plant Physiol 1997 May;114(1):119-29
3,6,7,8-tetrahydro-3-((2-hydroxyethoxy)methyl)imidazo(4,5-d)(1,3)diazepin-8-ol  86646-88-0   Coformycin/*analogs & derivatives Adenosine Deaminase/antagonists & inhibitors. J Med Chem 1983;26(10):1478
isocoformycin  67187-35-3 imidazo(4,5-d)(1,3)diazepin-7-ol, 3,4,7,8-tetrahydro-3-beta-D-ribofuranosyl  *Coformycin Isomerism. J Antibiot (Tokyo) 1980;33(3):303

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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