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Colchicine

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Definition: A major alkaloid from Colchicum autumnale L. and found also in other Colchicum species. Its primary therapeutic use is in the treatment of gout, but it has been used also in the therapy of familial Mediterranean fever (PERIODIC DISEASE).     
Pharmacological Action Gout Suppressants; Tubulin Modulators
Examples Demecolcine; Lumicolchicines 		Other names Colchicine, (R)-Isomer; Colchicine, (+-)-IsomerDrugs* : COLCRYS
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
NSC 51046  0   Colchicine/*analogs & derivatives. J Org Chem. 2010 Dec 3;75(23):8241-51
188Re(CO)3-colchicine iminodiacetic acid  0   *Coordination Complexes Colchicine/*analogs & derivatives Rhenium. Cancer Biother Radiopharm 2008 Dec;23(6):741-8
CT20126  0   Colchicine/*analogs & derivatives. Exp Mol Med 2007 Apr 30;39(2):230-8
3-desmethylthiocolchicine  0   Colchicine/*analogs & derivatives. J Chromatogr A 2002 Mar 8;949(1-2):71-7
3-O-demethylcolchicine-3-O-glucopyranoside  0   *Glucosides Colchicine/*analogs & derivatives. Nat Prod Lett 2001;15(4):217-9
colchicone  0   Colchicine/*analogs & derivatives. Oncol Res 1999;11(3):145-52
THC 18  0   Colchicine/*analogs & derivatives. Biochem Biophys Res Commun 1999 Jan 19;254(2):334-7
THC 5  0   Colchicine/*analogs & derivatives. Biochem Biophys Res Commun 1999 Jan 19;254(2):334-7
1,2,3-O-acetyl-1,2,3-demethyl-N-(4'-nitrobenzoyl)deacetylthiocolchicine  0   Colchicine/*analogs & derivatives DNA Topoisomerases, Type II/antagonists & inhibitors. J Med Chem 1998 May 21;41(11):1956-61
tridemethyl-N-(4'-nitrobenzoyl)deacetylthiocolchicine  0   Colchicine/*analogs & derivatives DNA Topoisomerases, Type II/antagonists & inhibitors. J Med Chem 1998 May 21;41(11):1956-61
colchicide  518-15-0   Colchicine/*analogs & derivatives. Biochem J 1997 Nov 1;327(Pt 3):685-8
4-formylcolchicine  2730-82-7   Colchicine/*analogs & derivatives. Biotechnol Appl Biochem 1995 Aug;22( Pt 1):15-22
N-deacetyl-N-formylcolchicine  7411-12-3   Colchicine/*analogs & derivatives. Eur J Drug Metab Pharmacokinet 1992 Oct-Dec;17(4):243-6
2,3-didemethylcolchicine  57866-21-4 Acetamide, N-(5,6,7,9-tetrahydro-2,3-dihydroxy-1,10-dimethoxy-9-oxobenzo(a)heptalen-7-yl)-, (S)  Colchicine/*analogs & derivatives. Eur J Clin Invest 1992 Sep;22(9):630-4
3-chloroacetyl-3-demethylthiocolchicine  148731-66-2   Colchicine/*analogs & derivatives. Biochem Biophys Res Commun 1992 Sep 30;187(3):1350-8
2-chloroacetyl-2-demethylthiocolchicine  148731-67-3   Colchicine/*analogs & derivatives. Biochem Biophys Res Commun 1992 Sep 30;187(3):1350-8
N-acetoacetyl-N-deacetylcolchicine  88437-23-4   Colchicine/*analogs & derivatives. J Nat Prod 1990;53(4):1021
2-demethylspeciosine  111509-13-8   Colchicine/*analogs & derivatives. J Nat Prod 1990;53(4):1021
N-acetylcolchinol O-methyl ether  65967-01-3   Colchicine/*analogs & derivatives. J Biol Chem 1990;265(18):10255
(2-nitro-4-azidophenyl)deacetylcolchicine  111348-67-5   *Azides Colchicine/*analogs & derivatives. Biochemistry 1989;28(21):8515
isocolchicine  30771-10-9   *Colchicine Isomerism. J Biol Chem 1989;264(12):6682
cornigerine  6877-25-4   Colchicine/*analogs & derivatives. Biochem Pharmacol 1988;37(12):2445
6'-(4'-azido-2'-nitrophenylamino)hexanoyldeacetylcolchicine  98987-40-7   *Azides Colchicine/*analogs & derivatives. J Biol Chem 1985;260(25):13794
3-demethylthiocolchicine  87424-25-7   Colchicine/*analogs & derivatives. J Med Chem 1985;28(9):1204
2-demethylthiocolchicine  87424-26-8   Colchicine/*analogs & derivatives. J Med Chem 1985;28(9):1204
colchifoline  74515-40-5   Colchicine/*analogs & derivatives Spin Labels. J Med Chem 1984;27(12):1729
4-(hydroxymethyl)colchicine  3986-03-6   Colchicine/*analogs & derivatives Spin Labels. J Med Chem 1984;27(12):1729
allocolchicine  641-28-1   Colchicine/*analogs & derivatives Spin Labels. Acta Chem Scand (B) 1981;35(10):677
desacetamidocolchicine  1420-08-2   Colchicine/*analogs & derivatives. J Biol Chem 1981;256(12):6241
N-methylcolchiceinamide  63917-71-5   Colchicine/*analogs & derivatives. Antimicrob Agents Chemother 1981;19(3):465
colchicine amide  0   Colchicine/*analogs & derivatives. Chin Med J 1980;93(4):227
N,N-dimethylcolchiceinamide  2731-13-7 Acetamide, N-(10-(dimethylamino)-5,6,7,9-tetrahydro-1,2,3-trimethoxy-9-oxobenzo(a)heptalen-7-yl)-, (S)  Colchicine/*analogs & derivatives. J Chromatogr 1981;219(2):321
colchicenamide  3123-89-5   Colchicine/*analogs & derivatives. J Chromatogr 1981;219(2):321
N-acetylcolchinol  38838-26-5   Colchicine/*analogs & derivatives. Biochem Biophys Res Commun 83(2):472;1978
bromocolchicine  26195-69-7 Acetamide, 2-bromo-N-(5,6,7,9-tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo(a)heptalen-7-yl)-, (S)  Colchicine/*analogs & derivatives. Arch Int Physiol Biochim 86(1):212;1978
fluorescein colchicine  66091-34-7 Thiourea, N-(3',6'-dihydroxy-3-oxospiro(isobenzofuran-1(3H),9'-(9H)xanthen)-5-yl)-N'-(5,6,7,9-tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo(a)heptalen-7-yl)  *Fluoresceins Colchicine/*analogs & derivatives. J Cell Biol 76(3):619;1978
demethylisothiocolchicine  0   Colchicine/*analogs & derivatives. Biochem Biophys Res Comm 76(4):1293;1977
thiocholchicine  2730-71-4   Colchicine/*analogs & derivatives. Cancer Treat Rep 61(2):259;1977
colchicoside  477-29-2   Colchicine/*analogs & derivatives. J Chromatogr 131:444;1977
colchiceineamide-L-ephedrine phosphate  76109-92-7 Benzo(a)heptalen-9(5H)-one, 6,7-dihydro-1,2,3,10-tetramethoxy-7-(methyl(1-methyl-2-phenyl-2-(phosphonooxy)ethyl)amino)-, disodium salt, (7S-(7R*(1R*,2S*)))  Colchicine/*analogs & derivatives Ephedrine/*analogs & derivatives. Cancer Treat Rep 61(2):259;1977
colchiceine  477-27-0 O-demethylcolchicine  Colchicine/*analogs & derivatives. Acta Physiol Scand 1979;107(3):233; Experientia 1979;35(12):1572; Hoppe Seylers Z Physiol Chem 357(4):567;1976; Hoppe Seylers Z Physiol Chem 358:915;1977
trimethylcolchicinic acid  3482-37-9 (S)-7-amino-6,7-dihydro-10-hydroxy-1,2,3-trimethoxybenzo(a)heptalen-9(5H)-one  Colchicine/*analogs & derivatives. Eur J Biochem 50(3):563;1975
3-desmethylcolchicine  7336-33-6   Colchicine/*analogs & derivatives. J Natural Prod 36(3):338;1973
chlorcolchicine  26279-89-0   Colchicine/*analogs & derivatives. Schweiz Med Wochenschr 104(8):265;1974
thiocolchicoside  602-41-5   Colchicine/*analogs & derivatives. Chir Dent France 48(50):51;1978; Gynecol Prat 23(4):197;1972
trimethylcolchicinic acid methyl ether  3476-50-4 (S)-7-amino-6,7-dihydro-1,2,3,10-tetramethoxybenzo(a)heptalen-9(5H)-one  Colchicine/*analogs & derivatives. Cancer Chemother Rep 56(2):263;1972; Oncology 1980;37(1):62; Oncology 3(4):151;1976
androcymbine  2115-98-2   Colchicine/*analogs & derivatives. J Chem Soc (Org) 14(0):1736;1972

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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