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Colorectal Neoplasms, Hereditary Nonpolyposis

More information in Books or onNLM PubMed
Definition: A group of autosomal-dominant inherited diseases in which COLON CANCER arises in discrete adenomas. Unlike FAMILIAL POLYPOSIS COLI with hundreds of polyps, hereditary nonpolyposis colorectal neoplasms occur much later, in the fourth and fifth decades. HNPCC has been associated with germline mutations in mismatch repair (MMR) genes. It has been subdivided into Lynch syndrome I or site-specific colonic cancer, and LYNCH SYNDROME II which includes extracolonic cancer.  DF: HNPCC    Other names Lynch Syndrome; Hereditary Nonpolyposis Colorectal Neoplasms; Hereditary Nonpolyposis Colorectal Cancer; Syndrome, Lynch; Lynch Syndrome I; Lynch Cancer Family Syndrome I; Hereditary Nonpolyposis Colon Cancer; Colorectal Cancer Hereditary Nonpolyposis; Colon Cancer, Familial Nonpolyposis
 
SubstanceCAS Registry & nameCategoriesSource
Lynch cancer family syndrome 2  0   *Colorectal Neoplasms, Hereditary Nonpolyposis.
Lynch syndrome I (site-specific colonic cancer)  0   *Colorectal Neoplasms, Hereditary Nonpolyposis.
Colorectal cancer, hereditary nonpolyposis, type 1  0   *Colorectal Neoplasms, Hereditary Nonpolyposis.

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012

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