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Complement Inactivator Proteins

More information in Books or onNLM PubMed
Definition: Serum proteins that negatively regulate the cascade process of COMPLEMENT ACTIVATION. Uncontrolled complement activation and resulting cell lysis is potentially dangerous for the host. The complement system is tightly regulated by inactivators that accelerate the decay of intermediates and certain cell surface receptors.  do not confuse with COMPLEMENT INACTIVATING AGENTS; DF: COMPLEMENT INACT   
Pharmacological Action Complement Inactivating Agents
Examples Antigens, CD46; Complement C1 Inactivator Proteins; Complement C3 Nephritic Factor; Complement C3b Inactivator Proteins; Complement C4b-Binding Protein 		Other names Proteins, Complement Inactivator; Proteins, Complement Inactivating; Inactivators, Serum Complement; Inactivator Proteins, Complement; Inactivating Proteins, Complement; Complement Inactivators, Serum; Serum Complement Inactivators; Complement Inactivating Proteins; Complement Cytolysis Inhibitor Proteins; Complement Cytolysis Inhibiting Proteins
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
Ehp protein, Staphylococcus aureus  0   *Bacterial Proteins *Complement Inactivator Proteins. J Biol Chem 2007 Oct 12;282(41):30051-61
Isac protein, Ixodes scapularis  0   *Salivary Proteins and Peptides Complement Inactivator Proteins. J Biol Chem 2000 Jun 23;275(25):18717-23
factor J protein, human  0   *Glycoproteins Complement Inactivator Proteins. Clin Biochem 1994 Jun;27(3):169-76
low molecular weight inhibitor (complement)  0   *Complement Inactivator Proteins Complement Pathway, Alternative. Immunology 1980;41(4):789
anticomplement  0   *Complement Inactivator Proteins. Am J Clin Nutr 29(10):1089;1976

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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