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Complement C1

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Definition: The first complement component to act in the activation of CLASSICAL COMPLEMENT PATHWAY. It is a calcium-dependent trimolecular complex made up of three subcomponents: COMPLEMENT C1Q; COMPLEMENT C1R; and COMPLEMENT C1S at 1:2:2 ratios. When the intact C1 binds to at least two antibodies (involving C1q), C1r and C1s are sequentially activated, leading to subsequent steps in the cascade of COMPLEMENT ACTIVATION.  /antag permitted but consider also COMPLEMENT C1 INACTIVATOR PROTEINS   
Pharmacological Action Immunologic Factors
Examples Complement C1q; Complement C1r; Complement C1s 		Other names C1 Complement; Component 1, Complement; Complement, C1; Complement Component 1; Complement 1; C1, Complement
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
BSF 468248  0   *Oligopeptides Complement C1/antagonists & inhibitors. Methods Find Exp Clin Pharmacol 2003 Oct;25(8):611-6

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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