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Complement C2

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Definition: A component of the CLASSICAL COMPLEMENT PATHWAY. C2 is cleaved by activated COMPLEMENT C1S into COMPLEMENT C2B and COMPLEMENT C2A. C2a, the COOH-terminal fragment containing a SERINE PROTEASE, combines with COMPLEMENT C4B to form C4b2a (CLASSICAL PATHWAY C3 CONVERTASE) and subsequent C4b2a3b (CLASSICAL PATHWAY C5 CONVERTASE).     
Pharmacological Action Immunologic Factors
Examples Complement C2a; Complement C2b 		Other names Component 2, Complement; Complement, C2; C2, Complement; Complement Component 2; Complement 2; C2 Complement
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
complement C2, C allele protein  0   *Complement C2. Clin Immunol Immunopathol 1991;59(1):65

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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