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Complement C3

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Definition: A glycoprotein that is central in both the classical and the alternative pathway of COMPLEMENT ACTIVATION. C3 can be cleaved into COMPLEMENT C3A and COMPLEMENT C3B, spontaneously at low level or by C3 CONVERTASE at high level. The smaller fragment C3a is an ANAPHYLATOXIN and mediator of local inflammatory process. The larger fragment C3b binds with C3 convertase to form C5 convertase.     
Pharmacological Action Immunologic Factors 		Other names Pro-C3; Pro Complement 3; Precursor, Complement C3; Precursor, C3; Precursor Complement 3; Component 3, Complement; Complement, C3; C3, Complement; C3 Precursor, Complement; Pro-Complement 3; Precursor-Complement 3; Complement Component 3; Complement C3 Precursor; Complement 3; C3 Precursor; C3 Complement; Pro C3
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
CPAMD8 protein, human  0   *alpha-Macroglobulins *Complement C3 *Trypsin Inhibitor, Kazal Pancreatic. Genomics 2004 Jun;83(6):1083-93
complement C3u protein, human  94949-15-2   *Complement C3. Protein Expr Purif 1994 Apr;5(2):170-7
C3 protein, human  0   *Complement C3 Nephritis, Hereditary. J Biol Chem 1983;258(11):7200

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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