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Complement C3b

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Definition: The larger fragment generated from the cleavage of COMPLEMENT C3 by C3 CONVERTASE. It is a constituent of the ALTERNATIVE PATHWAY C3 CONVERTASE (C3bBb), and COMPLEMENT C5 CONVERTASES in both the classical (C4b2a3b) and the alternative (C3bBb3b) pathway. C3b participates in IMMUNE ADHERENCE REACTION and enhances PHAGOCYTOSIS. It can be inactivated (iC3b) or cleaved by various proteases to yield fragments such as COMPLEMENT C3C; COMPLEMENT C3D; C3e; C3f; and C3g.  /antag: consider COMPLEMENT C3B INACTIVATOR PROTEINS   
Pharmacological Action Immunologic Factors
See Also Receptors, Complement 3b
Examples Complement C3c; Complement C3d 		Other names iC3b; Component 3b, Complement; Complement, C3b; C3b, Inactivated; C3b, Complement; Inactivated C3b; Complement Component 3b; Complement 3b; C3b Complement; C3bi
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
complement C3f-des-arginine  0   *Complement C3b. Arthritis Rheum 2007 Jun;56(6):2018-30
C3 beta c  0   *Complement C3b *Peptide Fragments. Biochem Biophys Res Commun 1993 Aug 16;194(3):1181-7
complement C3bBa complex  0   *Complement C3b *Complement Factor B. J Biol Chem 1987;262(4):1519
complement C3f  0   *Complement C3b. Complement. 1988;5(1):27; J Pediatr 1985;107(4):564
complement C3d,g  0   *Complement C3b *Peptide Fragments. J Biochem (Tokyo) 1985;97(1):373
complement C3d-k  0   *Complement C3b *Peptide Fragments. J Biol Chem 1985;260(5):2597
complement C3e  0   *Complement C3b *Peptide Fragments. Clin Immunol Immunopathol 1984;30(2):321
complement C3g  0   *Complement C3b. J Exp Med 1982;156(1):205

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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