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Complement C9

More information in Books or onNLM PubMed
Definition: A 63-kDa serum glycoprotein encoded by gene C9. Monomeric C9 (mC9) binds the C5b-8 complex to form C5b-9 which catalyzes the polymerization of C9 forming C5b-p9 (MEMBRANE ATTACK COMPLEX) and transmembrane channels leading to lysis of the target cell. Patients with C9 deficiency suffer from recurrent bacterial infections.     
Pharmacological Action Immunologic Factors 		Other names Component 9, Complement; Complement, C9; C9, Complement; Complement Component 9; Complement 9; C9 Complement
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
complement C9b  83534-36-5   *Complement C9. Biochemistry 1986;25(5):1094
complement C9 polymer  0   *Complement C9 Complement Membrane Attack Complex. J Biol Chem 1984;259(3):1922

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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