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Corticotropin-Releasing Hormone

More information in Books or onNLM PubMed
Definition: A peptide of about 41 amino acids that stimulates the release of ADRENOCORTICOTROPIC HORMONE. CRH is synthesized by neurons in the PARAVENTRICULAR NUCLEUS of the HYPOTHALAMUS. After being released into the pituitary portal circulation, CRH stimulates the release of ACTH from the PITUITARY GLAND. CRH can also be synthesized in other tissues, such as PLACENTA; ADRENAL MEDULLA; and TESTIS.  DF: CRH   
Pharmacological Action Hormones
See Also Receptors, Corticotropin-Releasing Hormone 		Other names CRF-41; ACTH-Releasing Hormone; Corticotropin-Releasing Hormone-41; Corticotropin-Releasing Factor; Corticotropin Releasing Hormone 41; Corticotropin Releasing Hormone; Corticotropin Releasing Factor 41; Corticotropin Releasing Factor; ACTH Releasing Hormone; ACTH Releasing Factor; Corticotropin-Releasing Factor-41; Corticoliberin; CRF (ACTH); ACTH-Releasing Factor
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
GW 876008  0   *Pyrazoles *Bicyclo Compounds, Heterocyclic Corticotropin-Releasing Hormone/antagonists & inhibitors. J Pharm Biomed Anal 2010 Nov 2;53(3):517-25
4-(bis(2-methoxyethyl)amino)-2,7-dimethyl-8-(2-methyl-4-methoxyphenyl)pyrazolo(1,5-a)-1,3,5-triazine  0   *Pyrazoles *Triazines Corticotropin-Releasing Hormone/antagonists & inhibitors. J Pharm Sci 2009 Aug;98(8):2636-47
cyclo(31-34)(phenylalanyl(12)-norleucyl(21,28)-glutamyl(31)-lysyl(34))acetyl-corticotropin releasing factor (4-41)  0   *Peptides, Cyclic Corticotropin-Releasing Hormone/*analogs & derivatives Receptors, Corticotropin-Releasing Hormone/agonists. J Med Chem 2007 Apr 5;50(7):1668-74
urocortin 2, mouse  0   *Corticotropin-Releasing Hormone *Urocortins. Proc Natl Acad Sci USA 2001 Feb 27: 98(5):2843-8
urocortin 3, rat  0   *Corticotropin-Releasing Hormone *Urocortins. Endocrinology 2006 Oct;147(10):4578-88
6-cyclopropylmethyl-2-(2,4-dichlorophenyl)-7-ethyl-4-methyl-7,8-dihydro-6H-1,3,6,8a-tetraazaacenaphthylene  0   *Acenaphthenes Corticotropin-Releasing Hormone/antagonists & inhibitors. J Med Chem 2005 Sep 8;48(18):5780-93
prolyl-prolylisoleucine  0   *Corticotropin-Releasing Hormone *Peptide Fragments. Ross Fiziol Zh Im I M Sechenova. 2003 Aug;89(8):943-50
cortagine  0   *Corticotropin-Releasing Hormone *Recombinant Fusion Proteins. Proc Natl Acad Sci U S A 2004 Jun 22;101(25):9468-73
phenylalanyl corticotropin-releasing factor  0   Corticotropin-Releasing Hormone/*analogs & derivatives. Neuroscience 2003;122(1):1-4
corticotropin-releasing hormone, Pro(5)  0   Corticotropin-Releasing Hormone/*analogs & derivatives. Brain Res 2001 Dec 13;922(1):112-7
corticotropin-releasing hormone, Glu(20)  0   Corticotropin-Releasing Hormone/*analogs & derivatives. Brain Res 2001 Dec 13;922(1):112-7
UCN2 protein, human  0   *Corticotropin-Releasing Hormone *Urocortins. Nat Med 2001 May;7(5):605-11
UCN3 protein, human  0   *Corticotropin-Releasing Hormone *Urocortins. Nat Med 2001 May;7(5):605-11
4-(3-pentylamino)-2,7-dimethyl-8-(2-methyl-4-methoxyphenyl)pyrazolo(1,5-a)pyrimidine  0   *Pyrazoles *Pyrimidines Corticotropin-Releasing Hormone/antagonists & inhibitors. Bioorg Med Chem 2000 Jan;8(1):181-9
astressin B  0   *Corticotropin-Releasing Hormone *Peptide Fragments Corticotropin-Releasing Hormone. J Med Chem 1999 Aug 12;42(16):3175-82
phenylalanyl corticotropin-releasing factor (12-41)  0   Corticotropin-Releasing Hormone/*analogs & derivatives. J Neurosci 1998 Jul 15;18(14):5529-36
astressin  170809-51-5   *Corticotropin-Releasing Hormone *Peptide Fragments Corticotropin-Releasing Hormone/antagonists & inhibitors.
Pharma Action Neuroprotective Agents 		J Pharmacol Exp Ther 1997 Feb;280(2):754-60
diuretic hormone, mealworm  0   *Corticotropin-Releasing Hormone Diuresis Insect Hormones. Proc Natl Acad Sci U S A 1995 Dec 19;92(26):12323-7
corticorelin ovine  121249-14-7   Corticotropin-Releasing Hormone/*analogs & derivatives. Clin Pharmacol 1994 Jan;55(1):91ACTHREL
H-R corticotropin-releasing factor (12-41), Phe(12)-Nle(21,38), C(alpha-MeLeu(37))  0   *Peptide Fragments Corticotropin-Releasing Hormone/*analogs & derivatives. J Med Chem 1993 Oct 1;36(20):2860-7
Mas-DP II  139117-03-6   *Peptides Corticotropin-Releasing Hormone Insect Hormones. Biochem Biophys Res Commun 1991;181(3):927
alpha helical corticotropin-releasing hormone  0   *Corticotropin-Releasing Hormone.
Pharma Action Hormone Antagonists 		Life Sci 1991;48(24):2359
corticotropin-releasing hormone(12-41), Phe(12)-Nle(21,38)-alpha-Me-Leu(37)  129133-27-3   *Peptide Fragments Corticotropin-Releasing Hormone/*analogs & derivatives. Endocrinology 1991;128(4):2077
corticotropin releasing factor-binding protein  134773-81-2   *Carrier Proteins Corticotropin-Releasing Hormone. Nature 1991;349(6308):423
corticotropin-releasing hormone (12-41), Phe(12)-Nle(21,38)  129133-41-1   *Peptide Fragments Corticotropin-Releasing Hormone/*analogs & derivatives. J Physiol (Lond) 1990;421:1
corticotropin-releasing hormone, iodo-Tyr(0)  130120-58-0   Corticotropin-Releasing Hormone/*analogs & derivatives. Endocrinology 1989;125(6):3068
corticotropen-releasing hormone, Nle(21,38)-Arg(36)  114308-86-0   Corticotropin-Releasing Hormone/*analogs & derivatives. Endocrinology 1988;122(4):1695
corticotropin releasing hormone, biotinyl-Ser(1)  105883-79-2   Corticotropin-Releasing Hormone/*analogs & derivatives. Endocrinology 1986;119(5):2129
alpha-helical corticotropin releasing hormone (3-41), Tyr(3), Pro(4), Nle(18,21)  101178-72-7   Corticotropin-Releasing Hormone/*analogs & derivatives. Brain Res 1986;381(1):49
corticotropin releasing hormone (9-41)  96118-75-1   *Corticotropin-Releasing Hormone *Peptide Fragments.
Pharma Action Hormone Antagonists 		Brain Res 1985;328(2):355
pro-corticotropin releasing hormone  0   *Corticotropin-Releasing Hormone *Protein Precursors. Int J Pept Protein Res 1984;23(4):335
corticotropin-releasing hormone, Nle(21)-iodo-Tyr(32)  0   Corticotropin-Releasing Hormone/*analogs & derivatives. Brain Res 1984;296(1):202

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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