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Cyclodextrins

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Definition: A homologous group of cyclic GLUCANS consisting of alpha-1,4 bound glucose units obtained by the action of cyclodextrin glucanotransferase on starch or similar substrates. The enzyme is produced by certain species of Bacillus. Cyclodextrins form inclusion complexes with a wide variety of substances.  note specifics   
Examples alpha-Cyclodextrins; beta-Cyclodextrins; gamma-Cyclodextrins 		Other names Cycloheptaamylose; Cycloamylose; Cyclomaltooligosaccharides
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
mono-4-(N-6-deoxy-6-amino-beta-cyclodextrin)-7-nitrobenzofuran  0   *Benzofurans *Cyclodextrins. Int J Pharm. 2011 Jan 17;403(1-2):15-22
polyacrylamide-g-dextrin  0   *Acrylic Resins *Cyclodextrins. Int J Biol Macromol 2010 Dec 1;47(5):623-31
IT-101  0   *Camptothecin *Cyclodextrins. Proc Natl Acad Sci U S A. 2009 Jul 7;106(27):11394-9
mono-6A-(1-butyl-3-imidazolium)-6A-deoxycyclodextrin  0   *Cyclodextrins. Nat Protoc 2007;2(12):3195-200
heptakis(6-amino-6-deoxy)cyclodextrin  0   *Cyclodextrins. Chem Asian J 2007 Oct 1;2(10):1305-13
hexakis(6-amino-6-deoxy)cyclodextrin  0   *Cyclodextrins. Chem Asian J 2007 Oct 1;2(10):1305-13
CMC-CD compound  0   *Cyclodextrins Carboxymethylcellulose Sodium/*analogs & derivatives. Biotechnol Lett 2006 Sep;28(18):1465-70
acrylamidomethyl-gamma-cyclodextrin  0   *Cyclodextrins Hydrogel. Int J Pharm 2006 Apr 7;312(1-2):66-74
6-O-glucopyranosylcyclomaltohexaose  0   *Cyclodextrins. Carbohydr Res 2005 May 23;340(7):1343-50
poly(N-isopropylacrylamide-co-(acryloyl beta-cyclodextrin))  0   *Acrylic Resins *Cyclodextrins. Macromol Biosci 2005 Mar 15;5(3):192-6
cyclo(-6-glucopyranosyl-1-3-glucopyranosyl-1-6-glucopyranosyl-1-3-glucopyranosyl-1-)  0   *Cyclodextrins. Carbohydr Res 2005 Feb 28;340(3):449-54
cyclohexaicosaose  0   *Cyclodextrins. Carbohydr Res 2004 Jun 1;339(8):1427-37
6-O-tert-butyldimethylsilyl-2,3-methyl beta-cyclodextrin 2-2' thioureido dimer  0   *Cyclodextrins Thiourea/*analogs & derivatives. Chirality 2004 Oct;16(8):526-33
mono(6A-N-allylamino-6A-deoxy)-perphenylcarbamoylated beta-cyclodextrin  0   *Cyclodextrins. J Chromatogr A. 2004 Mar 26;1031(1-2):135-42
(6-O-carboxymethyl-2,3-di-O-methyl)cyclomaltoheptaose  0   *Cyclodextrins. Carbohydr Res 2004 Jan 22;339(2):241-9
heptakis(2,3,6-tri-O-methyl)cyclomaltoheptaose  0   *Cyclodextrins. Carbohydr Res 2003 Sep 26;338(20):2091-9
heptakis(2,6-di-O-methyl)cyclomaltoheptaose  0   *Cyclodextrins. Carbohydr Res 2003 Sep 26;338(20):2091-9
heptakis(2,3-di-O-acetyl-6-O-sulfo)-beta-cyclodextrin  0   *Cyclodextrins. Electrophoresis. 2003 Aug;24(15):2487-98
heptakis(2,3,4-tri-O-methyl)beta-cyclodextrin  0   *Cyclodextrins. FASEB J 2004 Mar;18(3):574-6
cyclomaltohexaicosaose  0   *Cyclodextrins. Carbohydr Res 2003 Apr 22;338(9):977-86
pseudopolyrotaxane  0   *Cyclodextrins *Poloxamer *Rotaxanes. Spectrochim Acta A Mol Biomol Spectrosc 2003 Jan 15;59(2):285-9
polyrotaxane  0   *Cyclodextrins *Poloxamer *Rotaxanes. Spectrochim Acta A Mol Biomol Spectrosc 2003 Jan 15;59(2):285-9
benzoisoselenazolone  0   *Cyclodextrins. Carbohydr Res 2002 Aug 16;337(14):1309-12
cyclodextrin itraconazole  0   *Cyclodextrins *Itraconazole. Antimicrob Agents Chemother 2002 Aug;46(8):2554-63
heptakis(2,3,6-tri-O-(sodium 5-carboxyl-3-thiapentyl))-cyclodextrin  0   *Cyclodextrins. Carbohydr Res 2002 Feb 11;337(3):217-20
di-O-(N-acetyl-glucosaminyl)cyclomaltoheptaose  0   *Cyclodextrins Glucosamine/*analogs & derivatives. Carbohydr Res 2001 Nov 21;336(3):203-11
dicyclodextrinyl ditelluride  0   *Cyclodextrins *Organometallic Compounds Tellurium. FEBS Lett 2001 Nov 2;507(3):377-80
6-trimethylammonio-deoxycyclodextrin  0   *Cyclodextrins. Electrophoresis 2001 Feb;22(3):478-83
maltosyl-cyclodextrin  0   *Cyclodextrins Maltose/*analogs & derivatives. Biol Pharm Bull 2001 Apr;24(4):395-402
heptakis(2-O-methyl)cyclomaltoheptaose  0   *Cyclodextrins. Carbohydr Res 2000 Sep 8;328(2):217-27
heptakis(2-O-methyl-3,6-di-O-tert-butyldimethylsilyl)cyclomaltoheptaose  0   *Cyclodextrins. Carbohydr Res 2000 Sep 8;328(2):217-27
heptakis(2,6-di-O-tert-butyldimethylsilyl)cyclomaltoheptaose  0   *Cyclodextrins. Carbohydr Res 2000 Sep 8;328(2):217-27
cyclohenicosakis((1-2)gluco-henicosapyranosyl)  0   *Cyclodextrins. Carbohydr Res 2000 Jun 16;326(3):227-34
ADVASEP 7  0   *Cyclodextrins. Neuron 1999 Dec;24(4):809-17
vinylpyrrolidine-beta-cyclodextrin copolymer  0   *Cyclodextrins *Pyrrolidines. Electrophoresis 1999 Sep;20(13):2614-8
delta-cyclodextrin  0   *Cyclodextrins. Drug Dev Ind Pharm 1999 Aug;25(8):951-4
sulfolipo-cyclodextrin  0   *Cyclodextrins. Vaccine 1999 Jan 21;17(3):219-28
maltohexanoic acid  0   *Cyclodextrins. Biochem Cell Biol 1998;76(2-3):189-97
maltohexaitol  0   *Cyclodextrins. Biochem Cell Biol 1998;76(2-3):189-97
cyclomaltoheptaose heptadecasulfate  0   *Cyclodextrins. Bioorg Med Chem 1996 Dec;4(12):2187-92
6-amino-6-deoxycyclomaltoheptaose octadecasulfate  0   *Cyclodextrins. Bioorg Med Chem 1996 Dec;4(12):2187-92
2-amino-2-deoxycyclomaltoheptaose heptadecasulfate  0   *Cyclodextrins. Bioorg Med Chem 1996 Dec;4(12):2187-92
6(I)-(6-aminohexyl)amino-6(I)-deoxycyclomaltoheptaose  0   *Cyclodextrins. Carbohydr Res 1996 Feb 28;282(1):125-35
6(I),6(II)-diamino-6(I),6(II)-dideoxycyclomaltoheptaose  0   *Cyclodextrins. Carbohydr Res 1996 Feb 28;282(1):41-52
testosterone cyclodextrin  0   *Cyclodextrins Testosterone/*analogs & derivatives. J Clin Endocrinol Metab 1995 Dec;80(12):3567-75
Chirasil-Dex  140877-08-3   *Cyclodextrins *Siloxanes. Electrophoresis 1994 Jun;15(6):835-41
cyclorhamnopentaose  159495-25-7   *Cyclodextrins. Chem Pharm Bull (Tokyo) 1994 Jun;42(6):1365-6
benzylated cycloisomaltotetraose  153440-04-1   *Cyclodextrins. Carbohydr Res 1993 Oct 4;248:377-84
6-O-(galactopyranosyl)cyclomaltoheptaose  149496-53-7   *Cyclodextrins Drug Carriers. Biosci Biotechnol Biochem 1993 May;57(5):850-1
diglucosyl-cyclomaltohexaose  0   *Cyclodextrins. Chem Pharm Bull (Tokyo) 1992 May;40(5):1125-9
6-O-(maltosyl)cyclomaltohexaose  100817-30-9   *Cyclodextrins. Carbohydr Res 1992 Mar 30;226(2):197-208
2-O-(2-hydroxypropyl)cyclomaltoheptaose  130981-23-6   *Cyclodextrins. Carbohydr Res 1991 Dec 30;222:37-45
chymotrypsin beta-benzyme  EC 3.4.21.-   *Chymotrypsin Cyclodextrins. Proc Natl Acad Sci USA 1987;84(3):673
6-deoxy-6-fluorocyclomaltoheptaose  99552-37-1   *Cyclodextrins. Carbohydr Res 1985;143:107
cyclomaltoheptaose-1-adamantanemethanol  101412-93-5   *Cyclodextrins Adamantane/*analogs & derivatives. Carbohydr Res 1985;142(1):21
cyclodextrin polymer  0   *Cellulose *Cyclodextrins Polymers. Chem Pharm Bull (Tokyo) 1984;32(2):665
cyclodextrin glucoamylase  EC 3.2.1.-   *Glucosidases Cyclodextrins. Eur J Biochem 1981;115(2):287
cyclomaltodextrin glucanotransferase  EC 2.4.1.19   *Glucosyltransferases Cyclodextrins. Carbohydr Res 1979;75:243; Carbohydr Res 1980;78(1):133; Carbohydr Res 61:229;1978

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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