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Cysteine Endopeptidases

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Definition: ENDOPEPTIDASES which have a cysteine involved in the catalytic process. This group of enzymes is inactivated by CYSTEINE PROTEINASE INHIBITORS such as CYSTATINS and SULFHYDRYL REAGENTS.  do not confuse with CYSTEINE PROTEASES   
Examples Bromelains; Calpain; Caspases; Cathepsin B; Cathepsin F; Cathepsin H; Cathepsin K; Cathepsin L; Cathepsin W; Chymopapain; Ficain; Papain
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
OTUB1 protein, C elegans  EC 3.4.22.-   *Cysteine Endopeptidases *Caenorhabditis elegans Proteins. Nature. 2012 Mar 29;483(7391):618-22
MCA-1 protein, Plasmodium falciparum  EC 3.4.22.-   *Cysteine Endopeptidases. PLoS One. 2011;6(8):e23867.
ELS1 protein, Arabidopsis  EC 3.4.22.-   *Cysteine Endopeptidases *Arabidopsis Proteins. Planta 2011 Jan;233(1):63-73
ESD4 protein, Arabidopsis  EC 3.4.22.-   *Cysteine Endopeptidases *Arabidopsis Proteins. Planta 2011 Jan;233(1):63-73
USP26 protein, mouse  EC 3.1.2.15   *Cysteine Endopeptidases. Asian J Androl. 2009 Jul;11(4):478-83
ATG4D protein, human  EC 3.4.22.-   *Cysteine Endopeptidases. J Cell Sci. 2009 Jul 15;122(Pt 14);2554-66
otubain 1 protein, human  EC 3.4.22.-   *Cysteine Endopeptidases. Biochem J 2009 Mar 1;418(2):379-90
OTS2 protein, Arabidopsis  EC 3.4.22.-   *Cysteine Endopeptidases *Arabidopsis Proteins. Plant Cell 2008 Oct;20(10):2894-908
OTS1 protein, Arabidopsis  EC 3.4.22.-   *Cysteine Endopeptidases *Arabidopsis Proteins. Plant Cell 2008 Oct;20(10):2894-908
TbcatB protein, Trypanosoma brucei  EC 3.4.22.-   *Cysteine Endopeptidases. J Biol Chem 2008 Oct 24;283(43):28934-43
Spr protein, E coli  EC 3.4.22.-   *Cysteine Endopeptidases *Escherichia coli Proteins. Biochemistry 2008 Sep 16;47(37):9715-7
cysteine protease 2, Giardia lamblia  EC 3.4.22.-   *Cysteine Endopeptidases. J Biol Chem 2008 Jun 27;283(26):18024-31
metacaspase-8, Arabidopsis  EC 3.4.22.-   *Cysteine Endopeptidases *Arabidopsis Proteins. J Biol Chem 2008 Jan 11;283(2):774-83
Cwp84 protein, Clostridium difficile  EC 3.4.22.-   *Cysteine Endopeptidases. J Bacteriol 2007 Oct;189(20):7174-80
echinus protein, Drosophila  EC 3.1.2.15   *Cysteine Endopeptidases *Drosophila Proteins. BMC Dev Biol 2007;7:82
Atg4C protein, mouse  EC 3.4.22.-   *Cysteine Endopeptidases. J Biol Chem 2007 Jun 22;282(25):18573-83
MCA5 protein, Trypanosoma cruzi  EC 3.4.22.-   *Cysteine Endopeptidases *Protozoan Proteins. Biocell 2006 Dec;30(3):479-90
MCA3 protein, Trypanosoma cruzi  EC 3.4.22.-   *Cysteine Endopeptidases *Protozoan Proteins. Biocell 2006 Dec;30(3):479-90
UfSP2 protein, mouse  EC 3.4.22.-   *Cysteine Endopeptidases. J Biol Chem 2007 Feb 23;282(8):5256-62
UfSP1 protein, mouse  EC 3.4.22.-   *Cysteine Endopeptidases. J Biol Chem 2007 Feb 23;282(8):5256-62
Tysnd1 protein, rat  EC 3.4.22.-   *Cysteine Endopeptidases. EMBO J 2007 Feb 7;26(3):835-45
Ctsla protein, zebrafish  EC 3.4.22.-   *Cathepsins *Zebrafish Proteins Cysteine Endopeptidases. Gene 2007 Jan 15;386(1-2):98-106
NudE-like protein, rat  EC 3.4.22.-   *Cysteine Endopeptidases. Proc Natl Acad Sci U S A 2003 Jan 7;100(1):289-94
SUSP4 protein, mouse  EC 3.4.22.-   *Cysteine Endopeptidases. Nat Cell Biol 2006 Dec;8(12):1424-31
Tnfaip3 protein, mouse  EC 3.4.22.-   *Cysteine Endopeptidases *Intracellular Signaling Peptides and Proteins Nuclear Proteins.
Mc27 protein, Paragonimus westermani  EC 3.4.22.-   *Cysteine Endopeptidases. Cell Microbiol 2006 Jun;8(6):1034-46
Mc28 protein, Paragonimus westermani  EC 3.4.22.-   *Cysteine Endopeptidases. Cell Microbiol 2006 Jun;8(6):1034-46
CYLD protein, mouse  EC 3.1.2.15   *Cysteine Endopeptidases. Cell 2006 May 19;125(4):665-77
sortase E  0   *Bacterial Proteins *Cysteine Endopeptidases *Aminoacyltransferases.
sortase D  0   *Bacterial Proteins *Cysteine Endopeptidases *Aminoacyltransferases.
sortase C  0   *Bacterial Proteins *Cysteine Endopeptidases *Aminoacyltransferases.
sortase B  0   *Bacterial Proteins *Cysteine Endopeptidases *Aminoacyltransferases Peptidoglycan.
UCHL3 protein, human  EC 3.1.2.15   *Cysteine Endopeptidases.
z-otu protein, zebrafish  EC 3.4.22.-   *Cysteine Endopeptidases *Zebrafish Proteins. Biochim Biophys Acta 2005 Dec 30;1732(1-3):1-7
fastuosain, Bromelia fastuosa  EC 3.4.22.-   *Cysteine Endopeptidases. Protein Pept Lett 2006 Jan;13(1):83-9
Fas2 antigen, Fasciola hepatica  EC 3.4.22.-   *Antigens, Helminth *Cysteine Endopeptidases. J Helminthol 2005 Sep;79(3):235-40
otubain 1 protein, mouse  EC 3.4.22.-   *Cysteine Endopeptidases Neoplasm Proteins. FEBS Lett 2006 Jan 9;580(1):179-83
ATG4B protein, human  EC 3.4.22.-   *Cysteine Endopeptidases. J Biol Chem 2005 Dec 2;280(48):40058-65
caricain II  EC 3.4.22.-   *Cysteine Endopeptidases *Peptide Fragments. Protein J 2005 May;24(4):243-51
Nep1 protein, S pombe  EC 3.4.22.-   *Cysteine Endopeptidases *Schizosaccharomyces pombe Proteins. Biochem J 2005 Jul 15;389(Pt 2):307-14
USP26 protein, human  EC 3.1.2.15   *Cysteine Endopeptidases. Eur J Hum Genet 2005 Mar;13(3):336-40
SENP2 protein, human  EC 3.4.22.-   *Cysteine Endopeptidases.
staphopain A protein, Staphylococcus aureus  EC 3.4.22.-   *Cysteine Endopeptidases. Biochem J 2005 Jan 1;385(Pt 1):181-7
MCP2b protein, Arabidopsis  EC 3.4.22.-   *Cysteine Endopeptidases *Arabidopsis Proteins. J Biol Chem 2005 Apr 15;280(15):14691-9
MCP1b protein, Arabidopsis  EC 3.4.22.-   *Cysteine Endopeptidases *Arabidopsis Proteins. J Biol Chem 2005 Apr 15;280(15):14691-9
SENP3 protein, human  EC 3.4.22.-   *Cysteine Endopeptidases. Mol Cell Biol 2005 Mar;25(6):2273-87
YDR533c protein, S cerevisiae  EC 3.4.22.-   *Heat-Shock Proteins *Saccharomyces cerevisiae Proteins Cysteine Endopeptidases. Structure (Camb) 2004 May;12(5):839-47
Protollin  0   *Cysteine Endopeptidases *Lipopolysaccharides Drug Combinations. Vaccine 2004 Sep 9;22(27-28):3691-7
Psmb10 protein, rat  EC 3.4.99.46   *Cysteine Endopeptidases.
Psmb10 protein, mouse  EC 3.4.99.46   *Cysteine Endopeptidases.
CASP2 protein, human  EC 3.4.22.-   *Cysteine Endopeptidases *Caspase 2 Apoptosis.
Casp2 protein, rat  EC 3.4.22.-   *Cysteine Endopeptidases Apoptosis.
alpha4 subunit, proteasome 20S, human  EC 3.4.25.1   *Cysteine Endopeptidases Protein Subunits. FEBS Lett 2004 Jul 2;569(1-3):211-6
HMCN1 protein, human  0   *Immunoglobulins Cysteine Endopeptidases. N Engl J Med 2004 Jul 22;351(4):346-53
ervatamin C, Ervatamia coronaria  EC 3.4.22.-   *Cysteine Endopeptidases. Biochemistry 2004 Feb 17;43(6):1532-40
hieronymain I, Bromelia hieronymi  EC 3.4.22.-   *Cysteine Endopeptidases. J Protein Chem 2003 Feb;22(2);127-34
Atg4bl protein, mouse  EC 3.4.22.-   *Cysteine Endopeptidases. J Biol Chem 2003 Dec 19;278(51):51841-50
morrenain b I, Morrenia brachystephana  EC 3.4.22.-   *Cysteine Endopeptidases. J Protein Chem 2003 Jan;22(1):15-22
3C-like protease, SARS coronavirus  EC 3.4.22.-   *Cysteine Endopeptidases *Viral Proteins. Proc Natl Acad Sci U S A 2003 Nov 11;100(23):13190-5
Pup1 protein, S cerevisiae  EC 3.4.25.1   *Cysteine Endopeptidases. Mol Microbiol 2003 Sep;49(5):1309-32
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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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