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Cytochalasins

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Definition: 11- to 14-membered macrocyclic lactones with a fused isoindolone. Members with INDOLES attached at the C10 position are called chaetoglobosins. They are produced by various fungi. Some members interact with ACTIN and inhibit CYTOKINESIS.  /antag permitted but consider also ANTITOXINS   
Examples Cytochalasin B; Cytochalasin D
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
10-phenyl-(12)-cytochalasins Z17  0   *Cytochalasins Alkaloids. Planta Med. 2010 Oct;76(14):1616-21
10-phenyl-(12)-cytochalasins Z16  0   *Cytochalasins Alkaloids. Planta Med. 2010 Oct;76(14):1616-21
xylarisin  0   *Cytochalasins. Chem Pharm Bull (Tokyo). 2009 Dec;57(12):1409-11
cytochalasin Z11  0   *Cytochalasins. Chem Biodivers 2009 May;6(5):739-45
cytochalasin Z10  0   *Cytochalasins. Chem Biodivers 2009 May;6(5):739-45
cytochalasin Z9  0   *Cytochalasins. J Nat Prod 2006 Jun;69(6):871-5
cytochalasin Z8  0   *Cytochalasins. J Nat Prod 2006 Jun;69(6):871-5
cytochalasin Z7  0   *Cytochalasins. J Nat Prod 2006 Jun;69(6):871-5
aspochalasin L  0   *Cytochalasins HIV Integrase/antagonists & inhibitors. J Antibiot (Tokyo) 2005 Apr;58(4):279-83
aspochalamin B  0   *Cytochalasins. J Antibiot (Tokyo). 2004 Nov;57(11):707-14
aspochalamin C  0   *Cytochalasins. J Antibiot (Tokyo). 2004 Nov;57(11):707-14
aspochalamin D  0   *Cytochalasins. J Antibiot (Tokyo). 2004 Nov;57(11):707-14
aspochalamin A  0   *Cytochalasins. J Antibiot (Tokyo). 2004 Nov;57(11):707-14
19,20-epoxycytochalasin Q  0   *Cytochalasins. J Nat Prod 2004 Jun;67(6):1036-8
aspochalasin I  0   *Cytochalasins. J Nat Prod 2004 Mar;67(3):328-32
aspochalasin K  0   *Cytochalasins. J Nat Prod 2004 Mar;67(3):328-32
aspochalasin J  0   *Cytochalasins. J Nat Prod 2004 Mar;67(3):328-32
cytochalasin Z6  0   *Cytochalasins. J Nat Prod 2003 Dec;66(12):1540-4
cytochalasin Z5  0   *Cytochalasins. J Nat Prod 2003 Dec;66(12):1540-4
cytochalasin Z4  0   *Cytochalasins. J Nat Prod 2003 Dec;66(12):1540-4
cytochalasin Z  0   *Cytochalasins. J Nat Prod 2002 Sep;65(9):1274-7
cytochalasin Y  0   *Cytochalasins. J Nat Prod 2002 Sep;65(9):1274-7
cytochalasin X  0   *Cytochalasins. J Nat Prod 2002 Sep;65(9):1274-7
aspochalasin H  0   *Cytochalasins. J Antibiot (Tokyo) 2002 Jul;55(7):666-8
aspochalasin D  0   Cytochalasins. J Antibiot (Tokyo) 2001 Apr;54(4):379-81
N1445  0   *Cytochalasins Caspase 1/antagonists & inhibitors. Cancer J Sci Am 1999 Sep-Oct;5(5):293-300
aspochalasin G  0   Cytochalasins. Jpn J Antibiot 1997 Nov;50(11):919-25
aspochalasin F  0   Cytochalasins. Jpn J Antibiot 1997 Nov;50(11):919-25
RKS 1778  0   *Cytochalasins. J Nat Prod 1997 Jul;60(7):669-72
cytochalasin J  0   *Cytochalasins. Cell Motil Cytoskeleton 1997;36(2):112-24
cytochalasin W  0   *Cytochalasins. Nat Toxin 1996;4(2):53-7
aspochalasin E  0   Cytochalasins. J Antibiot (Tokyo) 1993 Apr;46(4):679-81
18-dehydroxycytochalasin H  141994-72-1 1H-Cycloundec(d)isoindol-1-one, 15-(acetyloxy)-2,3,3a,4,5,6,6a,9,10,11,12,15-dodecahydro-6-hydroxy-4,10,12-trimethyl-5-methylene-3-(phenylmethyl)-, (3R*,3aS*,4R*,6R*,6aS*,7E,10R*,12R*,13E,15S*,15aS*)  *Cytochalasins *Isoindoles. J Antibiot (Tokyo) 1992 May;45(5):679-85
cytochalasin H  53760-19-3   *Cytochalasins. Exp Cell Biol 1982;50(3):155
cytochalasin H(2)B  74409-92-0 24-Oxa(14)cytochalasa-6(12),13,21-triene-1,23-dione, 7,20-dihydroxy-16-methyl-10-phenyl-, dihydro deriv., (7S,13E,16R,20R,21E)  *Cytochalasins. Biochim Biophys Acta 1981;676(3):338
cytochalasin C  22144-76-9   *Cytochalasins. J Biol Chem 1981;256(16):8663
cytochalasin A  14110-64-6   *Cytochalasins. J Cyclic Nucleotide Res 1981;7(1):1
deacetylcytochalasin H  53760-20-6   *Cytochalasins. J Agric Food Chem 1981;29(1):205
proxiphomine  52212-92-7   *Cytochalasins. Helv Chim Acta 56(7):2387;1973
protophomine  52212-93-8   *Cytochalasins. Helv Chim Acta 56(7):2387;1973
deoxaphomine  51053-39-5 7S,16R,20R-7,20-dihydroxy-16-methyl-10-phenyl-(13)cytochalasa-6(12),13(t),21(t)-tri ene-1,23-dione  *Cytochalasins. Helv Chim Acta 56(3):966;1973
cytochalasin E  36011-19-5   *Cytochalasins Mycotoxins Toxins, Biological.
Pharma Action Angiogenesis Inhibitors 		J Am Chem Soc 95(16):5423;1973; Toxicol Appl Pharmacol 1980;52(2):209

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