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Cytotoxins

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Definition: Substances that are toxic to cells; they may be involved in immunity or may be contained in venoms. These are distinguished from CYTOSTATIC AGENTS in degree of effect. Some of them are used as CYTOTOXIC ANTIBIOTICS. The mechanism of action of many of these are as ALKYLATING AGENTS or MITOSIS MODULATORS.  /antag permitted but consider also ANTITOXINS; coordinate with source of cytotoxin   
See Also Antineoplastic Agents; Cytostatic Agents
Examples Hemolytic Agents 		Other names Cytotoxic Agents; Cytolysins
Substances having this pharmacologic action: insulin crosslinked to the catalytic fragment A of diphtheria toxin; juglone; Granzymes; Perforin; Killer Factors, Yeast; Leukocidins; Zinostatin
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
BPSL1549 protein, Burkholderia pseudomallei  0   *Bacterial Proteins *Bacterial Toxins Cytotoxins Eukaryotic Initiation Factor-4A/antagonists & inhibitors. Science. 2011 Nov 11;334(6057):821-4
methyl spongoate  0   *Steroids Cytotoxins. Bioorg Med Chem Lett. 2007 May 1;17(9):2661-3
psymberin  0   *Pyrones Cytotoxins. Org Lett. 2004 Jun 10;6(12):1951-4
IB4-saporin conjugate  0   *Lectins *Ribosome Inactivating Proteins, Type 1 Cytotoxins. Brain Res. 2004 Dec 10;1029(1):65-76Brain Res. 2004 Dec 10;1029(1)
apratoxin C  0   *Depsipeptides Cytotoxins. Bioorg Med Chem 2002 Jun;10(6):1973-8
dehydroapratoxin A  0   *Depsipeptides Cytotoxins. Bioorg Med Chem 2002 Jun;10(6):1973-8
apratoxin B  0   *Depsipeptides Cytotoxins. Bioorg Med Chem 2002 Jun;10(6):1973-8
exoenzyme S  EC 2.4.2.31   *Bacterial Toxins *ADP Ribose Transferases Cytotoxins.
euplotin A  0   *Furans *Heterocyclic Compounds, 3-Ring Cytotoxins. J Am Chem Soc 2001 Sep 26;123(38):9455-6
leishporin protein, Leishmania  0   *Protozoan Proteins Cytotoxins. Infect Immun 2000 Aug;68(8):4578-84
magnificalysin III  0   *Peptides Cnidarian Venoms Cytotoxins Sea Anemones. Biochim Biophys Acta 2000 Mar 16;1478(1):9-18
intermedilysin protein, Streptococcus intermedius  0   *Bacteriocins Bacterial Toxins Cytotoxins. Infect Immun 1996 Aug;64(8):3093-100
Hirsutellin A protein, Hirsutella thompsonii  0   *Fungal Proteins Cytotoxins. J Invertebr Pathol 1999 Jul;74(1):96-7
cytolysin, Enterococcus faecalis  0   *Bacteriocins Cytotoxins. Med Microbiol Immunol (Berl) 1999 May;187(4):183-90
Gly1 protein, Neisseria gonorrhoeae  0   *Bacterial Proteins *Bacterial Toxins Cytotoxins. Infect Immun 1999 Feb;67(2):643-52
YopT protein, Yersinia  0   *Bacterial Proteins *Cysteine Endopeptidases Cytotoxins. Mol Microbiol 1998 Aug;29(3):915-29
pierisin protein, insect  0   *Insect Proteins *ADP Ribose Transferases Cytotoxins Apoptosis. Jpn J Cancer Res 1998 May;89(5):556-61
AN 238  0   Doxorubicin/analogs & derivatives Pyrroles Cytotoxins. Proc Natl Acad Sci U S A 1998 Feb 17;95(4):1794-9
TER 286  158382-37-7   Glutathione/*analogs & derivatives Cytotoxins. Anticancer Drugs 1997 Apr;8(4):345-8
C-SAR protein, Aspergillus clavatus  0   *Fungal Proteins *Ribonucleases Aspergillus Cytotoxins. Toxicon 1997 Mar;35(3):383-92
2-bromo-6-(glutathion-S-yl)hydroquinone  114865-64-4   *Hydroquinones Glutathione/*analogs & derivatives Cytotoxins. Mol Pharmacol 1996 Sep;50(3):592-8
TX 109  0   *Aniline Compounds *Thiadiazoles Cytotoxins. Bioorg Med Chem 1996 Feb;4(2):247-53
TX 108  0   *Aniline Compounds *Thiadiazoles Cytotoxins. Bioorg Med Chem 1996 Feb;4(2):247-53
6,9-dioxa-5,10-di-(2,2,5,7,8-pentamethylchroman-6-sulfonyl)spermine  0   *Chromans Spermine/*analogs & derivatives Cytotoxins. Int J Biochem Cell Biol 1996 Jun;28(6):697-704
5-(4-methoxy-2,3,6-trimethylbenzenesulfonyl)-6-oxaspermidine  0   *Sulfonamides Spermidine/*analogs & derivatives Cytotoxins. Int J Biochem Cell Biol 1996 Jun;28(6):697-704
di-n-butylmalate  0   *Malates Cytotoxins. Z Naturforsch (C) 1996 Mar-Apr;51(3-4):233-42
serum tumorlytic factor  0   *Tumor Necrosis Factor-alpha Cytotoxins. Immunol Lett 1995 May;46(1-2):101-6
coelomic cytolytic factor 1, Eisenia fetida  0   *Lectins Cytotoxins. Immunol Lett 1995 Feb;45(1-2):123-8
bipolal  0   *Naphthalenes *Sesquiterpenes Cytotoxins. J Nat Prod 1995 Mar;58(3):463-6
nodularin R  0   *Peptides, Cyclic Cytotoxins. Nat Struct Biol 1995 Feb;2(2):114-6
motuporin  0   *Peptides, Cyclic Cytotoxins. Nat Struct Biol 1995 Feb;2(2):114-6
superstolide B  0   *Tetrahydronaphthalenes *Macrolides Cytotoxins. J Nat Prod 1994 Nov;57(11):1595-7
superstolide A  0   *Tetrahydronaphthalenes *Macrolides Cytotoxins. J Nat Prod 1994 Nov;57(11):1595-7
ApxI toxin, Bacteria  159035-78-6   *Bacterial Proteins *Hemolysin Proteins Bacterial Toxins Cytotoxins. Microb Pathog 1993 Dec;15(6):485-95
cytotoxic necrotizing factor type 2  0   *Bacterial Toxins *Escherichia coli Proteins Cytotoxins. Proc Natl Acad Sci U S A 1994 Apr 26;91(9):3814-8
magnificalysin II  155123-76-5 Magnificalysin II  *Peptides Cnidarian Venoms Cytotoxins Sea Anemones. Toxicon 1993 Dec;31(12):1567-79
magnificalysin I  155123-75-4 Magnificalysin I  *Peptides Cnidarian Venoms Cytotoxins Sea Anemones. Toxicon 1993 Dec;31(12):1567-79
swinholide A  95927-67-6   *Marine Toxins Cytotoxins. Chem Pharm Bull (Tokyo) 1994 Jan;42(1):19-26
ApxII toxin, bacteria  0   *Bacterial Proteins *Hemolysin Proteins Bacterial Toxins Carrier Proteins Cytotoxins. J Vet Med Sci 1993 Oct;55(5):813-9
CT14 cytotoxin, Naja naja atra  0   *Cobra Venoms Cytotoxins. Chung Kuo Yao Li Hsueh Pao 1992 Nov;13(6):544-6
russuphelin A  141794-49-2   *Anisoles *Chlorophenols Cytotoxins. Chem Pharm Bull (Tokyo) 1992 Dec;40(12):3185-8
repandiol  147921-90-2   *Alkynes *Epoxy Compounds Cytotoxins. Chem Pharm Bull (Tokyo) 1992 Dec;40(12):3181-4
lobomichaolide  145038-59-1 Oxireno(13,14)cyclotetradeca(1,2-b)furan-13(1aH)-one, 7,11-bis(acetyloxy)-2,3,6,7,10,11,11a,12,14a,14b-decahydro-1a,9-dimethyl-12-methylene-, (1aR*,4E,7S*,8E,11S*,11aR*,14aR*,14bS*)-(+)  *Diterpenes Cytotoxins. J Nat Prod 1992 Oct;55(10):1430-5
crassolide  66656-91-5   *Diterpenes Cytotoxins. J Nat Prod 1992 Oct;55(10):1430-5
basic fibroblast growth factor-saporin mitotoxin, recombinant  0   *Recombinant Fusion Proteins *Fibroblast Growth Factor 2 *Ribosome Inactivating Proteins, Type 1 Cytotoxins. J Cell Physiol 1992 Dec;153(3):483-90
cytotoxin P4  0   *Cobra Venoms Cytotoxins. Toxicon 1992 Sep;30(9):1122-6
isometachromin  145401-37-2   *Sesquiterpenes Cytotoxins. Experientia 1992 Sep 15;48(9):891-2
S-(3-oxopropyl)-N-acetylcysteine  140226-30-8   Acetylcysteine/*analogs & derivatives Cytotoxins. Chem Res Toxicol 1992 May-Jun;5(3):360-5
ascidiacyclamide  86701-12-4   *Peptides, Cyclic Cytotoxins. Biopolymers 1992 Feb;32(2):131-43
cynaropicrin  35730-78-0   *Lactones *Sesquiterpenes Cytotoxins. Neuropharmacology 1992 Mar;31(3):271-7
solstitialin A 13-acetate  24470-33-5   *Lactones Cytotoxins. Neuropharmacology 1992 Mar;31(3):271-7
Karwinskia toxin T-514  110270-61-6   *Anthracenes Cytotoxins Rhamnaceae. TOXICOLOGY 1992;73(2):191-201
Karwinskia toxin T-544  56678-09-2   *Anthracenes *Pyrans Cytotoxins Rhamnaceae. TOXICOLOGY 1992;73(2):191-201
VacA protein, Helicobacter pylori  0   *Bacterial Proteins Bacterial Toxins Carrier Proteins Cytotoxins Vacuoles Helicobacter pylori. J Biol Chem 1992 May 25;267(15):10570-5
8-pentanoylneosolaniol  116163-74-7   *Trichothecenes Cytotoxins Fusarium. J Nat Prod 1991 Sep-Oct;54(5):1303-8
enterolobin protein, Enterolobium contortisiliquum  136362-84-0   *Plant Proteins Cytotoxins. Toxicon 1991;29(9):1143-50
alpha-diphenylene-N-(4-(bis-(beta-hydroxyethyl)amino)phenyl)nitrone  65869-14-9   *Ethanolamines Cytotoxins. J Cancer Res Clin Oncol 1991;117(3):239
Kid protein, Bacteria  0   *Bacterial Proteins *Bacterial Toxins Cytotoxins. Mol Gen Genet 1991;225(3):355
purealidin A  134850-51-4 Benzenepropanamide, N-(2-(2-amino-1H-imidazol-4-yl)ethyl)-4-(3-aminopropoxy)-3,5-dibromo-alpha-(hydroxyimino)  *Alkaloids Cytotoxins Porifera. Experientia 1991;47(3):299
6-cyano-5-methoxyindolo(2,3-a)carbazole  131926-78-8   *Carbazoles Cytotoxins. J Antibiot (Tokyo) 1990;43(10):1236
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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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