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Dactinomycin

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Definition: A compound composed of a two CYCLIC PEPTIDES attached to a phenoxazine that is derived from STREPTOMYCES parvullus. It binds to DNA and inhibits RNA synthesis (transcription), with chain elongation more sensitive than initiation, termination, or release. As a result of impaired mRNA production, protein synthesis also declines after dactinomycin therapy. (From AMA Drug Evaluations Annual, 1993, p2015)     
Pharmacological Action Anti-Bacterial Agents; Antibiotics, Antineoplastic; Nucleic Acid Synthesis Inhibitors; Protein Synthesis Inhibitors 		Other names Meractinomycin; Actinomycin D; Actinomycin; Lyovac, Cosmegen; Merck Sharp & Dohme Brand of Dactinomycin; Merck Frosst Brand of Dactinomycin; Merck Brand of Dactinomycin; MSD Brand of Dactinomycin; Lyovac-Cosmegen; Lemery Brand of Dactinomycin; Cosmegen Lyovac; Cosmegen; Ac-DeDrugs* : DACTINOMYCIN; COSMEGEN
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
VAD regimen 2  0   *Antineoplastic Combined Chemotherapy Protocols Dactinomycin Doxorubicin Vincristine. Cancer Chemother Pharamcol 2008 Nov;62(6):1039-44
actinomycin D, valyl(2,2')-N-methylleucyl(5,5')  0   Dactinomycin/*analogs & derivatives. Cancer Lett 2008 Sep 8;268(1):38-45
MEA regimen  0   *Antineoplastic Combined Chemotherapy Protocols Leucovorin Dactinomycin Etoposide Methotrexate. J Reprod Med 2004 Jun;49(6):438-42
BOP-CISCA-POMB-ACE regimen  0   *Antineoplastic Combined Chemotherapy Protocols Bleomycin Cisplatin Cyclophosphamide Dactinomycin Doxorubicin Etoposide Methotrexate Vincristine. Br J Cancer 2002 May 20;86(10):1555-60
BAP protocol 2  0   *Antineoplastic Combined Chemotherapy Protocols Bleomycin Cisplatin Dactinomycin. Oncol Rep. 2000 Nov-Dec;7(6):1235-8
MAE protocol  0   *Antineoplastic Combined Chemotherapy Protocols Dactinomycin Etoposide Methotrexate. Br J Cancer 1999 Mar;79(9-10):1531-3
actinomycin C2  2612-14-8   Dactinomycin/*analogs & derivatives. Bioorg Med Chem Lett 1998 Aug 4;8(15):2001-2
actinomycin VII  0   Dactinomycin/*analogs & derivatives. Bioorg Med Chem Lett 1998 Aug 4;8(15):2001-2
VACAD protocol  0   *Antineoplastic Combined Chemotherapy Protocols Cyclophosphamide Dacarbazine Dactinomycin Doxorubicin Vincristine. Med Pediatr Oncol 1998 Apr;30(4):201-9
8-fluoro-actinomycin D  0   Dactinomycin/*analogs & derivatives. Bioorg Med Chem 1997 Jun;5(6):1197-207
POMB-ACE regimen  0   *Antineoplastic Combined Chemotherapy Protocols Bleomycin Cisplatin Cyclophosphamide Dactinomycin Etoposide Methotrexate Vincristine. Gan To Kagaku Ryoho 1995 Oct;22(12):1847-50
N8-actinomycin D  0   Dactinomycin/*analogs & derivatives. Biochemistry 1995 Jul 4;34(26):8481-91
aurantin  522-16-7   *Dactinomycin.
N-(4-nitrobenzyloxycarbonyl)actinomycin D  0   Dactinomycin/*analogs & derivatives. J Med Chem 1994 Oct 14;37(21):3452-8
DD1 protocol  0   *Antineoplastic Combined Chemotherapy Protocols Bleomycin Cyclophosphamide Dactinomycin Ifosfamide Methotrexate. Cancer Treat Res 1993;62:327-32
T10 A protocol  0   *Antineoplastic Combined Chemotherapy Protocols Bleomycin Cisplatin Cyclophosphamide Dactinomycin Doxorubicin. Cancer Treat Res 1993;62:327-32
PEA regimen  0   *Antineoplastic Combined Chemotherapy Protocols Cisplatin Dactinomycin Etoposide. Gynecol Oncol 1993 Jan;48(1):110-3
SIOP protocol  0   *Antineoplastic Combined Chemotherapy Protocols Dactinomycin Vincristine. Pediatr Pathol 1992 May-Jun;12(3):397-406
POMB-ACE-PAV regimen  0   *Antineoplastic Combined Chemotherapy Protocols Bleomycin Cisplatin Cyclophosphamide Dactinomycin Doxorubicin Etoposide Methotrexate Vinblastine Vincristine. Gynecol Oncol 1992 May;45(2):153-9
PEA-M regimen  0   *Antineoplastic Combined Chemotherapy Protocols Cisplatin Dactinomycin Etoposide Methotrexate. Acta Obstet Gynecol Scand 1991;70(7-8):611-3
Kengshenmycin  0   *Dactinomycin. Chin Med J (Engl) 1991;104(2):156
T-6 protocol  0   *Antineoplastic Combined Chemotherapy Protocols Bleomycin Cyclophosphamide Dactinomycin Doxorubicin Methotrexate Vincristine. Med Pediatr Oncol 1991;19(4):228
IVA protocol  0   *Antineoplastic Combined Chemotherapy Protocols Dactinomycin Ifosfamide Vincristine. Rev Chir Orthop 1989;75(8):566
VAIA protocol  0   *Antineoplastic Combined Chemotherapy Protocols Dactinomycin Doxorubicin Ifosfamide Vincristine. Cancer Chemother Pharmacol 1989;24(Suppl):S48
VACA protocol  0   Cyclophosphamide *Antineoplastic Combined Chemotherapy Protocols Dactinomycin Doxorubicin Vincristine. Cancer Chemother Pharmacol 1989;24(Suppl):S48
7-azidoactinomycin D  121051-59-0 Actinomycin D, 7-azido  Dactinomycin/*analogs & derivatives. J Biol Chem 1989;264(13):7262
VAB-6 regimen  0   *Antineoplastic Combined Chemotherapy Protocols Bleomycin Cisplatin Cyclophosphamide Dactinomycin Vinblastine. J Clin Oncol 1988;6(8):1231
VAB protocol  0   *Antineoplastic Combined Chemotherapy Protocols Bleomycin Dactinomycin Vinblastine. Clin Pharm 1987;6(9):693
Rosen's T-10 protocol  0   *Antineoplastic Combined Chemotherapy Protocols Bleomycin Cyclophosphamide Dactinomycin Doxorubicin Methotrexate. J Clin Oncol 1987;5(8):1304
EMACO protocol  0   *Antineoplastic Combined Chemotherapy Protocols Leucovorin Dactinomycin Doxorubicin Etoposide Methotrexate Vincristine. Eur J Cancer Clin Oncol 1986;22(12):1483
MOMK protocol  0   *Antineoplastic Combined Chemotherapy Protocols Dactinomycin/analogs & derivatives Mechlorethamine Methotrexate Vincristine. Chung Hua Chung Liu Tsa Chih 1986;8(6):470
MOFK protocol  0   *Antineoplastic Combined Chemotherapy Protocols Dactinomycin/analogs & derivatives Fluorouracil Mechlorethamine Vincristine. Chung Hua Chung Liu Tsa Chih 1986;8(6):470
ABV-ADV protocol  0   *Antineoplastic Combined Chemotherapy Protocols Bleomycin Dacarbazine Dactinomycin Doxorubicin Vinblastine Vincristine. Am J Med 1987;82(3):456
chounghwamycin A  104245-07-0 Chounghwamycin A  Dactinomycin/*analogs & derivatives. Proc Natl Acad Sci Counc Repub China (B):1986;10(2):98
EMA-CO protocol  0   Etoposide *Antineoplastic Combined Chemotherapy Protocols Cyclophosphamide Dactinomycin Methotrexate Vincristine. Br J Obstet Gynaecol 1986;93(1):63
CHAMOMA protocol  0   *Antineoplastic Combined Chemotherapy Protocols Leucovorin Cyclophosphamide Dactinomycin Doxorubicin Hydroxyurea Methotrexate Vincristine. Gynecol Oncol 1986;23(1):87
BCD protocol  0   *Antineoplastic Combined Chemotherapy Protocols Bleomycin Cyclophosphamide Dactinomycin. Nuklearmedizin 1985;24(2):75
CHAMOCA regimen  0   Doxorubicin *Antineoplastic Combined Chemotherapy Protocols Cyclophosphamide Dactinomycin Hydroxyurea Vincristine. J Reprod Med 1984;29(11):813
T7 protocol  0   *Antineoplastic Combined Chemotherapy Protocols Bleomycin Leucovorin Cyclophosphamide Dactinomycin Doxorubicin Methotrexate Vincristine. Ann Pediatr (Paris) 1984;31(9):773
MAC III protocol  0   *Antineoplastic Combined Chemotherapy Protocols Leucovorin Cyclophosphamide Dactinomycin Methotrexate. Gynecol Oncol 1984;19(2):173
7-(2,3-epoxypropoxy)actinomycin D  82830-18-0   Dactinomycin/*analogs & derivatives. J Med Chem 1984;27(11):1465
actinomycin X  50813-20-2   Dactinomycin/*analogs & derivatives. Mikrobiologiia 1984;53(2):251
FDV protocol  0   *Antineoplastic Combined Chemotherapy Protocols Dactinomycin Fluorouracil Vincristine. Eur J Obstet Gynecol Reprod Biol 1984;17(1):33
actinomycin D-dATGCAT complex  53360-01-3   *Dactinomycin *Oligodeoxyribonucleotides. Biochemistry 1984;23(3):403
MDC protocol  0   *Antineoplastic Combined Chemotherapy Protocols Chlorambucil Dactinomycin Methotrexate. Ginekol Pol 1983;54(10):641
VAB II protocol  0   Bleomycin *Antineoplastic Combined Chemotherapy Protocols Cisplatin Dactinomycin Vinblastine. Rev Med Brux 1983;4(4):219
MAC combination  0   *Antineoplastic Combined Chemotherapy Protocols Cyclophosphamide Dactinomycin Methotrexate. Arch Fr Pediatr 1983;40(2):85
actinomycin S3  11097-67-9   Dactinomycin/*analogs & derivatives. Jpn J Physiol 1983;33(1):129
POMB-ACE protocol  0   *Antineoplastic Combined Chemotherapy Protocols Bleomycin Cyclophosphamide Cytarabine Dactinomycin Etoposide Methotrexate Vincristine. Lancet 1983;1(8331):948
AcFuCy protocol  0   *Antineoplastic Combined Chemotherapy Protocols Cyclophosphamide Dactinomycin Fluorouracil. Obstet Gynecol 1983;61(2):194
VAB-IV protocol  0   *Antineoplastic Combined Chemotherapy Protocols Bleomycin Chlorambucil Cisplatin Cyclophosphamide Dactinomycin Doxorubicin Vinblastine. Can J Surg 1982;25(3):265
VAB-III protocol  0   *Antineoplastic Combined Chemotherapy Protocols Bleomycin Chlorambucil Cisplatin Cyclophosphamide Dactinomycin Vinblastine. Cancer Treat Rep 1982;66(6):1405
actinomycin K  11011-00-0   Dactinomycin/*analogs & derivatives. Chung Huo Yao Li Hseuh Pao 1982;3(1):51
bis-actinomycin D  0   Dactinomycin/*analogs & derivatives. FEBS Lett 1981;136(1):53
actinomycin D2  72751-56-5 Actinomycin D, 7-((hydroxyacetyl)amino)-, ester with L-valylglycoloyl-L-valine  Dactinomycin/*analogs & derivatives. Dokl Akad Nauk SSSR 1981;260(1):239
actinomycin D1  72766-92-8 Actinomycin D, 7-((hydroxyacetyl)amino)-, ester with L-valine  Dactinomycin/*analogs & derivatives. Dokl Akad Nauk SSSR 1981;260(1):239
cactinomycin  8052-16-2   Dactinomycin/*analogs & derivatives. Antibiotiki 1981;26(4):246
gluconimycin  11003-95-5 Gluconimycin  Dactinomycin/*analogs & derivatives. J Antibiot (Tokyo) 1980;33(10):1208
7-aminoactinomycin D  7240-37-1   Dactinomycin/*analogs & derivatives.
Pharma Action Fluorescent Dyes 		Chromosoma 1980;79(1):1
desaminoactinomycin C  23067-37-0   Dactinomycin/*analogs & derivatives. Riv Biol 69(3-4):169;1976
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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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