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Deoxyribonuclease I

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Definition: An enzyme capable of hydrolyzing highly polymerized DNA by splitting phosphodiester linkages, preferentially adjacent to a pyrimidine nucleotide. This catalyzes endonucleolytic cleavage of DNA yielding 5'-phosphodi- and oligonucleotide end-products. The enzyme has a preference for double-stranded DNA.  do not confuse X ref STREPTODORNASE with STREPTODORNASE AND STREPTOKINASE: see note there; DF: note short X ref   
Examples Streptodornase and Streptokinase 		Other names Streptodornase; DNase I; T7 Endonuclease I; T4 Endonuclease II; Endonuclease, DNA; DNase, Pancreatic; Thymonuclease; T7-Endonuclease I; T4-Endonuclease II; Pancreatic DNase; Nickase; Endonuclease I; Dornavac; DNAase I; DNA Nicking Enzyme; DNA Endonuclease
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
LINE-1 endonuclease, human  EC 3.1.21.1   *Deoxyribonuclease I. Proteins 2009 Mar;74(4):917-28
Imds-60 protein, mouse  0   *Membrane Proteins Deoxyribonuclease I. Acta Biochim Biophys Sin (Shanghai) 2007 Dec;39(12):939-46
BspD6I protein, E coli  EC 3.1.21.1.   *Deoxyribonuclease I *Escherichia coli Proteins. Biochemistry (Mosc) 2006 Jul;71(7):815-20
Sda1 protein, Streptococcus pyogenes  EC 3.1.21.1   *Deoxyribonuclease I. Mol Microbiol 2004 Oct;54(1);184-97
DNASE1L3 protein, rat  EC 3.1.21.1   *Deoxyribonuclease I. Biochemistry 1998 Jul 14;37(28):10134-43
DNASE1L2 protein, human  EC 3.1.21.-   *Deoxyribonuclease I. Genomics 1997 Jun 15;42(3):507-13
DNASE1L1 protein, human  EC 3.1.21.-   *Deoxyribonuclease I *Muscle Proteins. Hum Mol Genet 1995 Sep;4(9):1557-64
DNASE1 protein, human  EC 3.1.21.1   *Deoxyribonuclease I Cystic Fibrosis. JAMA 1994 Feb 16;271(7):494PULMOZYME
Distel  144236-70-4 1H-Pyrrole-2-carboxamide, 4-(((4-(formylamino)-1-methyl-1H-pyrrol-2-yl)carbonyl)amino)-N-(5-(((3-((9-methoxy-5,11-dimethyl-6H-pyrido(4,3-b)carbazol-1-yl)amino)propyl)amino)carbonyl)-1-methyl-1H-pyrrol-3-yl)-1-methyl  *Distamycins *Ellipticines Deoxyribonuclease I/antagonists & inhibitors. Biochemistry 1992 Dec 15;31(49):12385-96

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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