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Deoxyribonucleases

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Definition: Enzymes which catalyze the hydrolases of ester bonds within DNA. EC 3.1.-.  differentiate STREPTODORNASE referred to here and STREPTODORNASE AND STREPTOKINASE (see note there)   
Examples Endodeoxyribonucleases; Exodeoxyribonucleases 		Other names Nucleases, DNA; Desoxyribonucleases; DNase; DNAase; DNase, Alkaline; DNase, Acid; DNA Nucleases; Alkaline DNase; Acid DNase
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
SLX-1 protein, C elegans  EC 3.1.-   *Deoxyribonucleases *Caenorhabditis elegans Proteins. PLoS Genet 2009 Nov;5(11):e1000735
chelated EGTA activated nuclease, mouse  EC 3.1.-   *Deoxyribonucleases. Syst Biol Reprod Med 2009 Dec;55(5-6):193-9
MRT-1 nuclease, C elegans  EC 3.1.-.   *Deoxyribonucleases *Caenorhabditis elegans Proteins. EMBO J. 2009 Nov 18;28(22):3549-63
UL12 protein, herpes simplex virus 1  EC 3.1.-   *Deoxyribonucleases *Viral Proteins Herpesvirus 1, Human. J Virol 2009 Mar;83(6):2601-10
yjeA protein, E coli  EC 3.1.-   *Deoxyribonucleases *Escherichia coli Proteins. J Biochem. 2007 Nov;142(5):647-54
DFF40 protein, rat  EC 3.1.-   *Deoxyribonucleases. Biochem Biophys Res Commun 2006 Nov 17;350(2):457-62
BFN1 protein, Arabidopsis  0   *Deoxyribonucleases *Arabidopsis Proteins.
Dffb protein, mouse  EC 3.1.-   *Deoxyribonucleases. J Biol Chem 2005 Feb 18;280(7):6005-15
large molecular weight DNA fragmentation factor, Xenopus  EC 3.1.-   *Deoxyribonucleases *Xenopus Proteins. Cell Res 2004 Apr;14(2);134-40
Dffb protein, rat  EC 3.1.-   *Deoxyribonucleases Apoptosis.
SbcC protein, E coli  0   *Deoxyribonucleases *Escherichia coli Proteins Endodeoxyribonucleases Exodeoxyribonucleases Zinc Fingers.
mf2 protein, Streptococcus pyogenes  EC 3.1.-   *Bacterial Proteins *Deoxyribonucleases. Arch Microbiol 2002 Jun;177(6):451-6
mf3 protein, S pyogenes  EC 3.1.-   *Deoxyribonucleases. Arch Microbiol 2002 Jun;177(6):451-6
YncB protein, Bacillus subtilis  EC 3.1-   *Bacterial Proteins *Deoxyribonucleases. J Biol Chem 2001 Dec 14;276(50):47046-51
YokF protein, Bacillus subtilis  EC 3.1.-   *Bacterial Proteins *Deoxyribonucleases. J Biol Chem 2001 Dec 14;276(50):47046-51
Vvn protein, Vibrio vulnificus  EC 3.1.-   *Bacterial Proteins *Deoxyribonucleases. Appl Environ Microbiol 2001 Jan;67(1):82-8
Rep4 protein, Drosophila  EC 3.1.-   *Deoxyribonucleases *Drosophila Proteins. Cell Death Differ 1999 Sep;6(9):823-4
membrane nuclease MnuA protein, Mycoplasma pulmonis  EC 3.1.-   *Bacterial Proteins *Deoxyribonucleases. J Bacteriol 1999 Mar;181(6):1853-60
nuclease C1  EC 3.1.-   *Deoxyribonucleases. Eur J Biochem 1998 Aug 15;256(1):112-8
DFFB protein, human  EC 3.1.-   *Deoxyribonucleases Apoptosis. Proc Natl Acad Sci U S A 1998 Jul 21;95(15):8461-6
ZEN1 protein, zinnia  EC 3.1.30.-   *Deoxyribonucleases *Plant Proteins. FEBS Lett 1998 Jun 12;429(2):134-8
BEN1 protein, barley  EC 3.1.30.-   *Deoxyribonucleases *Plant Proteins. FEBS Lett 1998 Jun 12;429(2):134-8
caspase-activated DNase inhibitor  0   *Apoptosis Regulatory Proteins Deoxyribonucleases/antagonists & inhibitors Apoptosis.
Pharma Action Enzyme Inhibitors 		Nature 1998 Jan 1;391(6662):43-50
caspase-activated deoxyribonuclease  EC 3.1.-   *Deoxyribonucleases Apoptosis. Nature 1998 Jan 1;391(6662):43-50
novel human deoxyribonuclease  EC 3.1.-   *Deoxyribonucleases. Biochem Biophys Res Commun 1997 Feb 13;231(2):499-504
NucH protein, Aeromonas hydrophila  EC 3.1.-   *Bacterial Proteins *Deoxyribonucleases. J Bacteriol 1996 Jul;178(13):3926-33
deoxyribonuclease nuc-58  EC 3.1.-   *Deoxyribonucleases Apoptosis. FASEB J 1995 May;9(8):665-9
deoxyribonuclease nuc-40  EC 3.1.-   *Deoxyribonucleases Apoptosis. FASEB J 1995 May;9(8):665-9
deoxyribonuclease, Epstein-Barr virus  EC 3.1.11.-   *Deoxyribonucleases *Viral Proteins. Virology 1993 Oct;196(2):900-4
nucM protein, Erwinia chrysanthemi  EC 3.1.21.-   *Bacterial Proteins *Deoxyribonucleases. Mol Microbiol 1993 May;8(4):685-95
TRM2 protein, S cerevisiae  EC 3.1.-   *Deoxyribonucleases *tRNA Methyltransferases *Saccharomyces cerevisiae Proteins. Nucleic Acids Res 1992 Oct 11;20(19):5215-21
fragmentin  EC 3.4.21.-   *Deoxyribonucleases *Serine Endopeptidases DNA Damage. J Exp Med 1992 Feb 1;175(2):553-66
deoxyribonuclease C  EC 3.1.-   *Deoxyribonucleases. Microbiol Sci 1985;2(9):267
SbcC protein, Bacteria  0   *Bacterial Proteins *Deoxyribonucleases Endodeoxyribonucleases Exodeoxyribonucleases Zinc Fingers. Nucleic Acids Res 1989;17(20):8033
nucA protein, Bacillus subtilis  EC 3.1.-   *Deoxyribonucleases *DNA-Binding Proteins. Gene 1987;52(2-3):175
bromelain, deoxyribonuclease drug combination  0   *Bromelains *Deoxyribonucleases Drug Combinations. Minerva Stomatol 1986;35(5):503
primer activating enzymes  EC 3.1.4.-   *Deoxyribonucleases Endonucleases Exonucleases. Biochim Biophys Acta 1981;655(1):49
nuclease alpha  EC 3.1.11.-   *Deoxyribonucleases. J Biol Chem 1981;256(10):5087
splenic DNase I inhibitor  0   *Tissue Extracts Deoxyribonucleases/antagonists & inhibitors Spleen. Med Radiol (Mosk) 1981;26(3):56
GEL protein, Gelonium multiflorum  75037-46-6 Gelonin  *Ribosome Inactivating Proteins, Type 1 Deoxyribonucleases.
Pharma Action Antineoplastic Agents, Phytogenic ; Protein Synthesis Inhibitors 		J Biol Chem 1980;255(14):6947
deoxyribonuclease, plasmin drug combination  0 Nuclease, deoxyribo-, mixt. with plasmin  *Deoxyribonucleases *Fibrinolysin Drug Combinations. Aust NZ J Obstet Gynaecol 19(1):56;1979
deoxyribonuclease B  EC 3.1.4.-   *Deoxyribonucleases. New Zealand Med J 88(624):403;1978
deoxyribonuclease A  EC 3.1.4.-   *Deoxyribonucleases. Mol Biol (Mosk) 13(1):205;1979

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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