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Desipramine

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Definition: A tricyclic dibenzazepine compound that potentiates neurotransmission. Desipramine selectively blocks reuptake of norepinephrine from the neural synapse, and also appears to impair serotonin transport. This compound also possesses minor anticholinergic activity, through its affinity to muscarinic receptors.     
Pharmacological Action Adrenergic Uptake Inhibitors; Antidepressive Agents, Tricyclic; Enzyme Inhibitors 		Other names Desmethylimipramine; Novartis Brand of Desipramine Hydrochloride; Norpramin; Desipramine Hydrochloride; Demethylimipramine; Aventis Brand of Desipramine Hydrochloride; Aventis Behring Brand of Desipramine Hydrochloride; Apotex Brand of Desipramine Hydrochloride; Apo-Desipramine; Rh+¦ne Poulenc Rorer Brand of Desipramine Hydrochl; Nu Pharm Brand of Desipramine Hydrochloride; Hydrochloride, Desipramine; ratio-Desipramine; Temmler Brand of Desipramine Hydrochloride; Rh+¦ne-Poulenc Rorer Brand of Desipramine Hydrochl; Ratiopharm Brand of Desipramine Hydrochloride; Pharmascience Brand of Desipramine Hydrochloride; Petylyl; Pertrofran; PertofraneDrugs* : PERTOFRANE; DESIPRAMINE HYDROCHLORIDE; NORPRAMIN
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
10-hydroxydesipramine  4014-82-8   Desipramine/*analogs & derivatives. J Chromatogr B Biomed Appl 1997 May 23;693(1):153-8
N-acetyldesipramine  23047-26-9 Acetamide, N-(3-(10,11-dihydro-5H-dibenz(b,f)azepin-5-yl)propyl)-N-methyl  Desipramine/*analogs & derivatives. Pharmacol Toxicol 1992 Feb;70(2):121-4
2-iododesmethylimipramine  104880-94-6   Desipramine/*analogs & derivatives. Am J Physiol 1986;250(6 Pt 2):H1060
N-hydroxydesipramine  5227-91-8   Desipramine/*analogs & derivatives. Xenobiotica 1983;13(7):391
desipramine receptor  0   *Carrier Proteins *Receptors, Drug Desipramine. Neurosci Lett 1982;31(3):259
N-nitrosodesipramine  57164-17-7 5H-Dibenz(b,f)azepine-5-propanamine, 10,11-dihydro-N-methyl-N-nitroso  Desipramine/*analogs & derivatives. J Pharm Sci 1982;71(8):901
2-hydroxydesipramine  1977-15-7   Desipramine/*analogs & derivatives.
Pharma Action Antidepressive Agents, Tricyclic 		Eur J Clin Pharmacol 1981;19(1):61

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