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Dextromethorphan

More information in Books or onNLM PubMed
Definition: Methyl analog of DEXTRORPHAN that shows high affinity binding to several regions of the brain, including the medullary cough center. This compound is an NMDA receptor antagonist (RECEPTORS, N-METHYL-D-ASPARTATE) and acts as a non-competitive channel blocker. It is one of the widely used ANTITUSSIVES, and is also used to study the involvement of glutamate receptors in neurotoxicity.     
Pharmacological Action Antitussive Agents; Excitatory Amino Acid Antagonists 		Other names d-Methorphan; Hydrochloride, Dextromethorphan; Hydrobromide, Dextromethorphan; l-Methorphan; Racemethorphan; Levomethorphan; Dextromethorphan, (+-)-Isomer; Dextromethorphan Hydrochloride; Dextromethorphan Hydrobromide, Monohydrate; Dextromethorphan Hydrobromide, (+-)-Isomer; Dextromethorphan Hydrobromide; DelsymDrugs* : PROMETHAZINE DM; PROMETHAZINE W/ DEXTROMETHORPHAN; NUEDEXTA; DEXTROMETHORPHAN POLISTIREX; PROMETHAZINE HYDROCHLORIDE AND DEXTROMETHORPHAN HYDROBROMIDE; MUCINEX DM; PROMETH W/ DEXTROMETHORPHAN; PHERAZINE DM; PROMETHAZINE HYDROCHLORIDE AND DESTROMETHORPHAN HYDROBROMIDE; DELSYM
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
chlorphenamine, dextromethorphan, phenylephrine drug combination  0   *Chlorpheniramine *Dextromethorphan *Phenylephrine Drug Combinations.
acetaminophen, dextromethorphan, doxylamine succinate, pseudoephedrine drug combination  0   *Acetaminophen *Dextromethorphan *Pseudoephedrine Multi-Ingredient Cold, Flu, and Allergy Medications.
dextromethorphan - quinidine combination  0   *Dextromethorphan *Quinidine Drug Combinations. http://biz.yahoo.com/bw/061031/20061031005412.html?.v=1; Neurology. 2004 Oct 26;63(8):1364-70
acetaminophen, chlorpheniramine, dextromethorphan, phenylpropanolamine drug combination  0   *Acetaminophen *Chlorpheniramine *Dextromethorphan *Phenylpropanolamine Drug Combinations. Vet Hum Toxicol 2002 Jun;44(3):169-71
EN 3231  0   *Dextromethorphan *Morphine Drug Combinations. Curr Opin Investig Drugs 2002 Mar;3(3):459-62
Night Nurse  0   *Acetaminophen *Dextromethorphan *Phenylpropanolamine *Promethazine Drug Combinations. Eye 2001 Apr;15(Pt 2):248-9
AHN 649  0   *Excitatory Amino Acids Dextromethorphan/*analogs & derivatives. J Pharmacol Exp Ther 1999 Oct;291(1):399-408
norlevorphanol  1531-12-0   Dextromethorphan/*analogs & derivatives. J Chromatogr 1987;420(1):217
carbinoxamine, dextromethorphan, pseudoephedrine drug combination  0   *Dextromethorphan *Pyridines *Pseudoephedrine Drug Combinations.
Pharma Action Antitussive Agents ; Bronchodilator Agents ; Histamine H1 Antagonists ; Excitatory Amino Acid Antagonists 		Indiana Med 1985;78(9):766
Nyquil  0   *Acetaminophen *Dextromethorphan *Doxylamine *Pseudoephedrine Drug Combinations Nonprescription Drugs. N Engl J Med 1985;313(1):48
Sch 399  98125-69-0   *Dextromethorphan *Pseudoephedrine Cyproheptadine/*analogs & derivatives Drug Combinations. Clin Ther 1984;6(4):475
acetaminophen, pholcodine, pseudoephedrine drug combination  0   *Acetaminophen *Ascorbic Acid *Dextromethorphan Codeine/*analogs & derivatives Multi-Ingredient Cold, Flu, and Allergy Medications. J Int Med Res 1984;12(2):124
3-methoxymorphinan  1531-25-5 morphinan, 3-methoxy  Dextromethorphan/*analogs & derivatives. J Pharm Sci 1980;69(12):1447
d-3-methoxy-N-hydroxyethyl morphinan  65115-01-7 Morphinan-17-ethanol, 3-methoxy-, (9alpha,13alpha,14alpha)  Dextromethorphan/*analogs & derivatives. Agents Actions 7(3):339;1977

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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