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Dibenzocycloheptenes

More information in Books or onNLM PubMed
Definition: A family of tricyclic hydrocarbons whose members include many of the commonly used tricyclic antidepressants (ANTIDEPRESSIVE AGENTS, TRICYCLIC).     
Examples Amitriptyline; Butaclamol; Cyproheptadine; Dizocilpine Maleate; Nortriptyline; Protriptyline
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
5-(2-(2-(2-cyanopyrrolidin-1-yl)-2-oxoethylamino)propyl)-5-(1H-tetrazol-5-yl)-10,11-dihydro-5H-dibenzo(a,d)cycloheptene-2,8-dicarboxylic acid bisdimethylamide  0   *Dibenzocycloheptenes *Tetrazoles Dipeptidyl-Peptidase IV Inhibitors. Xenobiotica. 2011 Nov;41(11):945-57.
4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-(4-(2H-tetrazol-5-yl)butyl)piperidine  0   *Dibenzocycloheptenes *Piperidines. J Pharmacol Exp Ther. 2011 Nov;339(2):716-25.
amurensin G  0   *Dibenzocycloheptenes *Resorcinols. Mol Pharmacol 2010 Nov;78(5):855-64
faveline methyl ether  0   *Dibenzocycloheptenes. Org Lett 2010 Mar 19;12(6):1308-11
N-(8-methoxy-10,11-dihydro-5H-dibenzo(a,d)cycloheptene-10-ylmethyl)butyramide  0   *Dibenzocycloheptenes Polyunsaturated Alkamides Receptors, Melatonin/antagonists & inhibitors. J Med Chem 2004 Aug 12;47(17):4202-12
N-(8-methoxy-10,11-dihydro-5H-dibenzo(a,d)cycloheptene-10-ylmethyl)propionamide  0   *Dibenzocycloheptenes Polyunsaturated Alkamides Receptors, Melatonin/antagonists & inhibitors. J Med Chem 2004 Aug 12;47(17):4202-12
Ro 68-3400  0   *Dibenzocycloheptenes *Spiro Compounds. J Biol Chem 2003 Dec 12;278(50):49812-8
dibenzosuberanylpiperazine  0   *Dibenzocycloheptenes *Piperazines. J Med Chem 2003 May 8;46(10):1948-56
butriptyline  15686-37-0   *Dibenzocycloheptenes.
noxiptilin  3362-45-6   *Dibenzocycloheptenes.
Pharma Action Antidepressive Agents, Tricyclic 		Pharmazie 1984:39(8):548
zosuquidar trihydrochloride  0   *Dibenzocycloheptenes *Quinolines Drug Resistance, Multiple. Anticancer Res 1995 May-Jun;15(3):811-4
CP 117227  154531-78-9 1-Piperazineethanol, 4-(10,11-dihydro-5H-dibenzo(a,d)cyclohepten-5-yl)-alpha-((5-quinolinyloxy)methyl)-, (S)  *Dibenzocycloheptenes *Quinolines. Biochemistry 1994 May 3;33(17):5041-8
3-fluoro-10,5-(iminomethano)-10,11-dihydro-5H-dibenzo(a,d)cycloheptene  146364-05-8   *Dibenzocycloheptenes Ligands. J Med Chem 1993 Jul 9;36(14):1938-46
5H-dibenzo(a,d)cycloheptene-10,11-oxide  16145-11-2   *Dibenzocycloheptenes. Xenobiotica 1989;19(3):279
piroheptine  16378-21-5   *Dibenzocycloheptenes *Pyrrolidines. J Neurol Sci 1988;83(2-3):161
Wy 41770  4517-99-1   *Acetic Acids *Dibenzocycloheptenes. Agents Actions 1984;14(5-6):654
demexiptiline  24701-51-7   *Dibenzocycloheptenes. Ann Med Psychol (Paris) 1981;139(9):1023
3-chloro-N,N-dimethylspiro-(5H-dibenzo(a,d)cycloheptene-5,1' cyclohex-2'-ene)-4'amine 2  0   *Dibenzocycloheptenes. Acta Pharm Suec 1979;16(4):239
A 23887  61955-05-3   *Dibenzocycloheptenes *Spiro Compounds. Acta Pharm Suec 1979;16(4):239; Nature 263(5577):519;1976
cytenamide  10423-37-7 5H-dibenzo(a,d)cycloheptatriene-5-carboxamide  *Dibenzocycloheptenes. J Chromatog 134(2):299;1977
Ro 8-1998  27747-18-8 N,N-dimethyl-3-(1-methyl-5H-dibenzo(a,d)cycloheptene-5-ylidene)propylamine N-oxide.HCl  *Dibenzocycloheptenes. Int Pharmacopsychiatr 12(1):38;1977
dexclamol  34071-19-7 3-(2-propyl)-2,3,4,4a,8,9,13b,14-octahydro-1H-benzo(6,7)-cyclohepta(1,2,3,-de)pyrido(2,1-alpha)isoquinolin-3-ol  *Dibenzocycloheptenes. Br J Anaesth 48(12):1149;1977; J Pharm Sci 67(5):636;1978; Life Sci 23(5):459;1978; Naunyn Schmiedeberg Arch Pharm 295(2):117;1976
amineptin  57574-09-1 7-((10,11-dihydro-5H-dibenzo(a,d)cyclohepten-5-yl)amino)heptanoic acid  *Dibenzocycloheptenes.
Pharma Action Antidepressive Agents, Tricyclic ; Psychotropic Drugs 		Arzneim Forsch 28(2):262;1978; Encephale 4(2):131;1978; Eur J Pharmacol 42:113;1977; J Fr Otorhinolaryngol 26(9):729;1977; J Pharm Pharmacol 29(9):555;1977; Nouv Presse Med 5(14):924;1976; Psychopharmacologia 55(3):225;1977; S Afr Med J 51(3):62;1977; Sem Hop Ther 52(1):15;1976; Sem Hop Ther 53(7-8):368;1977
dibenzsuberone  1210-35-1 10,11-dihydro-5H-dibenzo(a,d)cyclohepten-5-one  *Dibenzocycloheptenes. Biochem Soc Trans 3(4):462;1975; J Pharm Soc Jpn 98(2):242;1978
N,N-dimethyl-5H-dibenzo(a,d)cycloheptene-delta 5,alpha-propylamine N-oxide  6682-26-4   *Dibenzocycloheptenes. Biomed Mass Spectroml (5):329;1974
cyheptropine  602-40-4 10,11-dihydro-5H-dibenzo(a,d)cycloheptene-5-carboxylic acid tropine ester  *Dibenzocycloheptenes. Arch Int Pharmacodyn Ther 205(1):61;1973
SC 28025  34252-81-8 6-(3-dimethylaminopropyl)-1,1a,6,10b-tetrahydrodibenzo(a,e)cyclopropa(c)cycloheptane oxalate  *Dibenzocycloheptenes. J Med Chem 17(1):72;1974
SC 27741  34252-66-9 6-(3-dimethylaminopropylidene)-1,1a,6,10b-tetrahydrodibenzo(a,e)cyclopropa(c)cycloheptene oxalate  *Dibenzocycloheptenes. J Med Chem 17(1):72;1974
SC 27123  34252-65-8 6-(3-methylaminopropylidene)-1,1a,6,10b-tetrahydrodibenzo(a,e)cyclopropa(c)cycloheptene oxalate  *Dibenzocycloheptenes. J Med Chem 17(1):72;1974
BS 7564  7530-51-0 8-azoniabicyclo(3.2.1)octane, 3-(((10,11-dihydro-5H-dibenzo(a,d)cyclohepten-5-yl)carbonyl)oxy)-8,8-dimethyl-, bromide, endo  *Dibenzocycloheptenes. Arch Int Pharmacodyn Ther 205(1):61;1973
MK 940  5154-92-7 (5 alpha,10 alpha,11 beta)-10,11-dihydro-5-(3-(methylamino)propyl)-5,10-epoxy-5H-dibenzo(a,d)cyclohepten-11-0l, (Z)-2-butenedioate (1:1) salt  *Dibenzocycloheptenes. Am J Ophthalmol 76(5):641;1973
5-(N-piperidino)-10,11-dihydro-5H-dibenzocycloheptene  37345-24-7   *Dibenzocycloheptenes. Nature 241(5391):551;1973
cyheptamide  7199-29-3 10,11-dihydro-5H-dibenzocycloheptene-5- carboxamide  *Dibenzocycloheptenes. Clin Chim Acta 43(1):69;1973
5-dimethylaminopropylidenemethyldibenzocycloheptene  33406-34-7 3-Buten-1-amine, 4-(5H-dibenzo(a,d)cyclohepten-5-yl)-N,N-dimethyl-, (E)-2-butenedioate  *Dibenzocycloheptenes. Arch Int Pharmacodyn Ther 192(2):265;1971
dibenzocycloheptatriene  256-81-5   *Dibenzocycloheptenes.
dibenzocycloheptadiene  833-48-7   *Dibenzocycloheptenes.

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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