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Dihydropteridine Reductase

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Definition: An enzyme that catalyzes the reduction of 6,7-dihydropteridine to 5,6,7,8-tetrahydropteridine in the presence of NADP+. Defects in the enzyme are a cause of PHENYLKETONURIA II. Formerly listed as EC 1.6.99.7.      Other names Reductase, Dihydropteridine; Reductase, 6,7-Dihydropteridine; 6,7 Dihydropteridine Reductase; 6,7-Dihydropteridine Reductase
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
hmp protein, E coli  EC 1.6.99.7   *Dihydropteridine Reductase *Hemeproteins *NADH, NADPH Oxidoreductases *Escherichia coli Proteins. Biochem Biophys Res Commun 1992 Aug 31;187(1):94-100
higenamine-1-carboxylic acid  56632-94-1 1-Isoquinolinecarboxylic acid, 1,2,3,4-tetrahydro-6,7-dihydroxy-1-((4-hydroxyphenyl)methyl)-, (+-)  *Alkaloids Dihydropteridine Reductase/antagonists & inhibitors. J Biol Chem 1982;257(13):7294

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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