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Dioxanes

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Definition: 1,4-Diethylene dioxides. Industrial solvents. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), dioxane itself may "reasonably be anticipated to be a carcinogen." (Merck Index, 11th ed)  indust solvents   
Examples Idazoxan; Piperoxan; Spectinomycin
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
2,5-dioxo-3-tetratriacont-3'-enyl-1,4-dioxane  0   *Dioxanes. J Asian Nat Prod Res. 2012;14(1):39-45
SR-0065  0   *Dioxanes *Quinolones. ACS Chem Biol. 2011 Jun 17;6(6):618-27.
1-(2,3-dihydrobenzo(b)(1,4)dioxin-6-yl)-4-((6-fluoropyridin-3-yl)methyl)piperazine  0   *Dioxanes *Piperazines Ligands Receptors, Dopamine D4. J Med Chem. 2011 Dec 22;54(24):8343-52.
2-(1'-methyl-2'-pyrrolidinyl)-7-hydroxy-1,4-benzodioxane  0   *Dioxanes *Pyrrolidines. J Med Chem. 2011 Nov 10;54(21):7588-601.
5-(((3-fluorophenyl)amino)methylidene)-2,2-dimethyl-1,3-dioxane-4,6-dione  0   *Aniline Compounds *Dioxanes. Acta Crystallogr C 2010 Aug;66(Pt 8):o392-5
1-(3',5'-dihydroxyphenoxy)-7-(2',4',6-trihydroxyphenoxy)-2,4,9-trihydroxydibenzo-1,4-dioxin  0   *Dioxanes Phloroglucinol/*analogs & derivatives. Mar Biotechnol (NY) 2010 Jun;12(3):299-307
10-carboxy-11,12,13,14-tetranor-plakortide Q  0   *Dioxanes. J Nat Prod. 2010 Apr 23;73(4):716-9
11,12-didehydro-13-oxo-plakortide Q  0   *Dioxanes. J Nat Prod. 2010 Apr 23;73(4):716-9
5-bromo-5-nitro-1,3-dioxane  0   *Dioxanes. Contact Dermatitis 2010 Jan;62(1):2-17
clinopodic acid C  0   *Dioxanes. J Nat Prod. 2009 Aug;72(8):1379-84
polydioxane sulfate  0   *Dioxanes *Polymers Absorbable Implants. Arch Orthop Trauma Surg 2009 Jun;129(6):735-40
poly(ethylene oxide)-b-poly(D,L-lactide)  0   *Dioxanes *Polyethylene Glycols. J Pharm Sci. 2009 Apr;98(4):1577-86
1-(3',5'-dihydroxyphenoxy)-7-(2'',4'',6''-trihydroxyphenoxy)-2,4,9-trihydroxydibenzo-1,4,-dioxin  0   *Dioxanes Phloroglucinol/*analogs & derivatives. Chem Biol Interact 2009 May 15;179(2-3):192-201
5-(6-(4-methanesulfonyloxyphenyl)hexyl)-2-methyl-1,3-dioxane-2-carboxylic acid  0   *Dioxanes *Mesylates. Bioorg Med Chem Lett 2008 Oct 15;18(20):5586-90
2-(2-pyrrolidinyl)benzodioxane  0   *Dioxanes *Pyrrolidines. Bioorg Med Chem Lett. 2009 Feb 1;19(3):854-9
4-cyano-4-(2,3-dihydro-8-methoxy-1,4-benzodioxin-5-yl)cyclohexanecarboxylic acid  0   *Cyclohexanecarboxylic Acids *Dioxanes Cyclic Nucleotide Phosphodiesterases, Type 4/antagonists & inhibitors. Int Immunopharmacol 2009 Jan;9(1):55-62
5,8-divinyl-1,4-dihydro-1,4-di-O-beta-D-glucopyranosyl-2,3-dioxane  0   *Dioxanes *Monosaccharides. J Asian Nat Prod Res. 2008 Sep-Oct;10(9-10):851-6
spiro(6-methyl-1,4-dioxane-2,5-dione-3,2'-bicyclo(2.2.1)hept(5)ene)  0   *Dioxanes *Spiro Compounds. J Am Chem Soc 2008 Oct 22;130(42):13826-7
3-methylene-6-methyl-1,4-dioxane-2,5-dione  0   *Dioxanes *Lactones. J Am Chem Soc 2008 Oct 22;130(42):13826-7
4-(2-(3-(4-hydroxy-3,5-dimethoxyphenyl)-2-hydroxymethyl-8-methoxy-2,3-dihydrobenzo(1,4)dioxin-6-yl)ethyl)-1-methoxybenzene  0   *Dioxanes. Chem Pharm Bull (Tokyo) 2008 Oct;56(10):1477-9
KW 4490  0   *Cyclohexanecarboxylic Acids *Dioxanes Cyclic Nucleotide Phosphodiesterases, Type 4/antagonists & inhibitors. Xenobiotica 2008 May;38(5):511-26
2-methyl-c-5-(4-(5-methyl-2-phenyl-1,3-oxazol-4-yl)butyl)-1,3-dioxane-r-2-carboxylic acid  0   *Dioxanes *Oxazoles. Bioorg Med Chem Lett 2008 Mar 15;18(6):2128-32
N,N,N-trimethyl(6-methyl-1,4-dioxan-2-yl)methanaminium iodide  0   *Dioxanes. Bioorg Med Chem Lett. 2008 Jan 15;18(2):614-8
phyllostin  0   *Dioxanes. J Agric Food Chem 2008 Feb 13;56(3):884-8
1,4-benzodioxan  0   *Dioxanes. Spectrochim Acta A Mol Biomol Spectrosc. 2007 Dec 31;68(5):1170-3
JNJ 10397049  0   *Dioxanes *Phenylurea Compounds. Am J Physiol Endocrinol Metab 2007 Oct;293(4):E977-85
5-nitroso-1,3-dioxan-5-yl 4-chlorobenzoate  0   *Chlorobenzoates *Dioxanes. Acta Crystallogr C 2007 Jun;63(Pt 6):o365-8
2,2-dimethyl-5-nitroso-1,3-dioxan-5-yl 4-chlorobenzoate  0   *Chlorobenzoates *Dioxanes. Acta Crystallogr C 2007 Jun;63(Pt 6):o365-8
2,2-dimethyl-5-nitroso-1,3-dioxan-5-yl benzoate  0   *Benzoates *Dioxanes. Acta Crystallogr C 2007 Jun;63(Pt 6):o365-8
(2-(2',3'-dihydrobenzo(1,4)dioxin-6'-yl)-2-hydroxy-1-pyrrolidin-1-ylmethylethyl)nonanoic acid amide  0   *Dioxanes *Pyrrolidines. Diabetes 2007 May;56(5):1210-8
2,2-dimethyl-1,3-dioxan-5-one  0   *Dioxanes. J Org Chem 2006 May 12;71(10):3822-8
zeylenone  0   *Cyclohexanes *Dioxanes. Chem Pharm Bull (Tokyo). 2006 Oct;54(10):1459-61
monomethoxy poly(ethylene glycol)-block-poly(trimethylene carbonate)  0   *Dioxanes *Polyethylene Glycols. J Control Release 2006 May 1;112(1):57-63
PX 916  0   *Dioxanes Glycine/*analogs & derivatives Thioredoxin-Disulfide Reductase/antagonists & inhibitors. Mol Cancer Ther 2006 Mar;5(3):630-6
peroxyacarnoate D  0   *Dioxanes. Org Lett 2005 Jun 9;7(12):2509-11
peroxyacarnoate A  0   *Dioxanes. Org Lett 2005 Jun 9;7(12):2509-11
eckstolonol  0   *Dioxanes *Heterocyclic Compounds with 4 or More Rings. Arch Pharm Res. 2005 Dec;28(12):1376-80
4,4,6-trimethyl-2-vinyl-1,3,2-dioxaborinane  0   *Boron Compounds *Dioxanes. Org Biomol Chem. 2005 Sep 7;3(17):3167-72
lecozotan  0   *Dioxanes *Piperazines Receptor, Serotonin, 5-HT1A/antagonists & inhibitors. J Med Chem 2005 May 19;48(10):3467-70
5,5-ditetradecyl-2-(2-trimethylammonioethyl)-1,3-dioxane bromide  0   *Dioxanes. Anal Sci. 2004 Jun;20(6):905-9
2-methyl-c-5-(4-(5-methyl-2-(4-methylphenyl)-4-oxazolyl)butyl)-1,3-dioxane-r-2-carboxylic acid  0   *Dioxanes *Oxazoles. J Pharmacol Exp Ther. 2004 Jun;309(3):970-7
(3-exo)-8-benzoyl-N-(((2S)7-chloro-2,3-dihydro-1,4-benzodioxin-1-yl)methyl)-8-azabicyclo(3.2.1)octane-3-methanamine monohydrochloride  0   *Dioxanes *Tropanes. Neuropsychopharmacology. 2003 Nov;28(11):1889-1902
BYI 06830  0   *Dioxanes *Hydrazines. Nature 2003 Nov 6;426(6962):91-6
plakortide N  0   *Dioxanes. J Nat Prod 2003 May;66(5):651-4
plakortide M  0   *Dioxanes. J Nat Prod 2003 May;66(5):651-4
artabotrycinol  0   *Dioxanes. Yao Xue Xue Bao 2001 Apr;36(4):281-6
5-(8-amino-7-chloro-2,3-dihydro-1,4-benzodioxin-5-yl)-3-(1-(2-phenylethyl)-4-piperidinyl)-1,3,4-oxadiazol-2(3H)-one  0   *Dioxanes *Oxadiazoles. J Pharmacol Exp Ther 2002 Aug;302(2):731-41
2-(4-(4-fluorophenyl)-5-(2-(3-cyclopropylmethyl)pyrimidin-4-yl)-1H-imidazol-2-yl)-5-methyl-(1,3)dioxane-5-carboxylic acid 4-methylpiperazinamide  0   *Dioxanes *Piperazines. J Med Chem 2002 May 23;45(11):2173-84
uretupamine A  0   *Dioxanes *Oxazoles. Nature 2002 Apr 11;416(6881):653-7
uretupamine B  0   *Dioxanes *Oxazoles. Nature 2002 Apr 11;416(6881):653-7
6-(4-benzylpiperazin-1-yl)benzodioxane  0   *Dioxanes *Piperazines. Bioorg Med Chem 2001 Dec;9(12):3207-13
trimethylene carbonate  0   *Dioxanes. Biomacromolecules 2000 Fall;1(3):493-500
5-methyl-5-benzyloxycarbonyl-1,3-dioxan-2-one  0   *Dioxanes. Biomacromolecules 2000 Fall;1(3):493-500
lennoxamine  0   *Dioxanes. Org Lett 2001 Nov 29;3(24):3923-5
N-hydroxyguanoxan  0   *Dioxanes *Guanidines. Bioorg Med Chem Lett 2001 Sep 3;11(17):2377-80
2,6-dimethyl-1,3-dioxane-4-ol  0   *Dioxanes. Chem Res Toxicol 2001 Aug;14(8):1025-32
methyl capucinoate A  0   *Dioxanes. J Nat Prod 2001 Mar;64(3):281-5
haterumadioxin B  0   *Dioxanes. J Nat Prod 2001 Mar;64(3):356-9
haterumadioxin A  0   *Dioxanes. J Nat Prod 2001 Mar;64(3):356-9
palmarumycin CP(1)  159933-90-1   *Dioxanes *Naphthalenes *Spiro Compounds. J Pharmacol Exp Ther 2001 Feb;296(2):364-71
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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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