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Distamycins

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Definition: Oligopeptide antibiotics from Streptomyces distallicus. Their binding to DNA inhibits synthesis of nucleic acids.     
Pharmacological Action Anti-Bacterial Agents; Nucleic Acid Synthesis Inhibitors
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
N-(2-(diethylamino)ethyl)-1-methyl-4-(1-methyl-4-(4-formamido-1-methylimidazole-2-carboxamido)pyrrole-2-carboxamido)imidazole-2-carboxamide  0   *Distamycins *Imidazoles. J Am Chem Soc 2005 Jan 19;127(2):742-50
MEN 10716  0   *Distamycins. Eur J Cancer 2002 Sep;38(13):1792-801
microgonotropen L2  0   *Benzimidazoles *Distamycins *Pyrroles. Proc Natl Acad Sci U S A 2001 Sep 11;98(19):10590-5
3-(1-methyl-4-(1-methyl4-(1-methyl-4-(8-(2'-carboxamidoethyloxy)-7-methoxy-1,2,3,11a-tetrahydro-5H-pyrrolo(2,1-c)(1,4)benzodiazepin-5-one)pyrrole-2-carboxamido)pyrrole-2-carboxamido)pyrrole-2-carboxamido)propionamidine  0   *Benzodiazepinones *Distamycins. Nucleosides Nucleotides Nucleic Acids 2000 Aug;19(8):1219-29
MT 17  0   *Distamycins. Nucleosides Nucleotides Nucleic Acids 2000 Aug;19(8):1365-79
MT 12  0   *Distamycins. Nucleosides Nucleotides Nucleic Acids 2000 Aug;19(8):1365-79
AR-1-144  0   *Distamycins. Eur J Biochem 1999 Aug;263(3):646-55
PNU 157977  0   *Distamycins *Nitrogen Mustard Compounds. Anticancer Drug Des 1999 Feb;14(1):71-6
PNU 151807  0   *Distamycins. Br J Cancer 1999 Jun;80(7):991-7
PNU 153429  0   *Distamycins. J Pharm Biomed Anal 1998 Mar;16(7):1153-8
chloroacetyldistamycin  0   *Distamycins. Rocz Akad Med Bialymst 1997;42(1):129-40
FCE 25450A  0   *Distamycins. Int J Cancer 1997 Sep 4;72(5):810-4
FCE 27784  0   *Distamycins. Br J Pharmacol 1997 Feb;120(3):537-43
microgonotropen pentaazapentabutylamine  0   *Distamycins. Bioorg Med chem 1996 Jun;4(6):803-13
FCE 27266  0   *Distamycins. Invasion Metastasis 1995;15(5-6):222-31
MEN 10710  0   *Distamycins *Nitrogen Mustard Compounds. Nucleic Acids Res 1996 Jan 15;24(2):311-5
distel(2+)  159506-80-6   *Distamycins *Ellipticines. Biochem Pharmacol 1995 Jul 31;50(3):424-8
2-imidazoledistamycin  142211-78-7   *Distamycins. Proc Natl Acad Sci USA 1994 Aug 2;91(16):7673-7
FCE 27164  154755-58-5 1,3,5-Naphthalenetrisulfonic acid, 7,7'-(carbonylbis(imino(1-methyl-1H-pyrrole-4,2-diyl)carbonylimino(1-methyl-1H-pyrrole-4,2-diyl)carbonylimino))bis-, hexasodium salt  *Distamycins. Biochem Pharmacol 1994 Jan 20;47(2):295-302
FCE 26644  0   *Distamycins. Biochem Pharmacol 1994 Jan 20;47(2):295-302
tren-microgonotropen-b  155056-06-7   *Distamycins. Proc Natl Acd Sci U S A Nov 1;90(12):10018-22
dien-microgonotropen-c  142155-06-4   *Distamycins. Proc Natl Acad Sci U S A 1993 Nov 1;90(21):10018-22
Distel  144236-70-4 1H-Pyrrole-2-carboxamide, 4-(((4-(formylamino)-1-methyl-1H-pyrrol-2-yl)carbonyl)amino)-N-(5-(((3-((9-methoxy-5,11-dimethyl-6H-pyrido(4,3-b)carbazol-1-yl)amino)propyl)amino)carbonyl)-1-methyl-1H-pyrrol-3-yl)-1-methyl  *Distamycins *Ellipticines Deoxyribonuclease I/antagonists & inhibitors. Biochemistry 1992 Dec 15;31(49):12385-96
FCE 24561  145875-38-3   *Distamycins. Toxicology 1992 Nov 15;75(3):209-19
thioformyldistamycin  139341-61-0   *Distamycins. J Biomol Struct Dyn 1991 Dec;9(3):599-611
tallimustine  115308-98-0 1H-Pyrrole-2-carboxamide, N-(5-(((3-amino-3-iminopropyl)amino)carbonyl)-1-methyl-1H-pyrrol-3-yl)-4-(((4-((4-(bis(2-chloroethyl)amino)benzoyl)amino)-1-methyl-1H-pyrrol-2-yl)carbonyl)amino)-1-methyl  *Distamycins *Nitrogen Mustard Compounds.
Pharma Action Antineoplastic Agents ; Antineoplastic Agents, Alkylating 		Cancer Res 1991;51(1):199
distamycin-DAPI  0   *Distamycins *Indoles. Cytogenet Cell Genet 1988;47(4):192
distamin  65361-29-7 1H-Pyrrole-2-carboxamide, N-(5-(((3-(dimethylamino)propyl)amino)carbonyl)-1-methyl-1H-pyrrol-3-yl)-4-(((4-(formylamino)-1-methyl-1H-pyrrol-2-yl)carbonyl)amino)-1-methyl  *Distamycins. Biofizika 1986;31(5):768
M-bromoacetyldistamycin  99328-13-9   *Distamycins. Ann NY Acad Sci 1986;471:51
distamycin-EDTA-iron(II)  0   *Distamycins *Edetic Acid *Organometallic Compounds Iron. Life Sci 1983;32(26):2915
stallimycin  636-47-5   *Distamycins.
Pharma Action Antiviral Agents 		Mol Biol (Mosk) 1980;14(1):94
permethyldistamycin A  75792-61-9 1H-Pyrrole-2-carboxamide, N-(5-(((3-amino-3-iminopropyl)amino)carbonyl)-1,2,4-trimethyl-1H-pyrrol-3-yl)-4-(((4-(4-formylamino)-1,3,5-trimethyl-1H-pyrrol-2-yl)carbonyl)amino)-1,3,5-trimethyl-, monohydrochloride  *Distamycins. J Med Chem 1981;24(1):33

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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