encyclopedia of medical concepts
ψ 

DNA Polymerase I

More information in Books or onNLM PubMed
Definition: A DNA-dependent DNA polymerase characterized in prokaryotes and may be present in higher organisms. It has both 3'-5' and 5'-3' exonuclease activity, but cannot use native double-stranded DNA as template-primer. It is not inhibited by sulfhydryl reagents and is active in both DNA synthesis and repair. EC 2.7.7.7.      Other names Pol I; Klenow Fragment; DNA-Dependent DNA Polymerase I; DNA Polymerase alpha; Polymerase alpha, DNA; Polymerase I, DNA; DNA Dependent DNA Polymerase I
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
INCURVATA2 protein, Arabidopsis  EC 2.7.7.-   *DNA Polymerase I *Arabidopsis Proteins Protein Subunits. Plant Cell 2007 Sep;19(9):2822-38
plakevulin A  0   *Cyclopentanes *Levulinic Acids DNA Polymerase I/antagonists & inhibitors. Bioorg Med Chem Lett 2004 Apr 19;14(8):1975-7
untenone A  0   *Cyclopentanes *Formates DNA Nucleotidylexotransferase/antagonists & inhibitors DNA Polymerase I/antagonists & inhibitors DNA Polymerase beta/antagonists & inhibitors. Bioorg Med Chem Lett 2004 Apr 19;14(8):1975-7
manzamenone A  0   *Formates *Indans DNA Nucleotidylexotransferase/antagonists & inhibitors DNA Polymerase I/antagonists & inhibitors Protein Kinase C/antagonists & inhibitors DNA Polymerase beta/antagonists & inhibitors. Bioorg Med Chem Lett 2004 Apr 19;14(8):1975-7
dehydroeburiconic acid  0   *Triterpenes DNA Polymerase I/antagonists & inhibitors DNA Polymerase beta/antagonists & inhibitors. Biosci Biotechnol Biochem 2004 Feb;68(2):448-50
DNA polymerase alpha-primase  EC 2.7.7.-   *DNA Polymerase I *DNA Primase. Mol Cell Biol 1999 Jan;19(1):646-56
Mus308 protein, Drosophila  0   *Drosophila Proteins *DNA Repair Enzymes DNA Polymerase I DNA Helicases. Mol Cell Biol 1996 Oct;16(10):5764-71
DNA polymerase I (2-87)  EC 2.7.7.-   *DNA Polymerase I *Peptide Fragments. Biochemistry 1994 Aug 16;33(32):9537-45
POL1 protein, S cerevisiae  EC 2.7.7.7   *DNA Polymerase I *Saccharomyces cerevisiae Proteins. Mol Microbiol 1993 Jul;9(1):221-3
DNA polymerase I (728-777)  0   *DNA Polymerase I *Peptide Fragments. Arch Biochem Biophys 1993 Feb 15;301(1):174-83
poly(malate)  78644-42-5   *Malates *Polymers DNA Polymerase I/antagonists & inhibitors DNA Primase/antagonists & inhibitors. Eur J Biochem 1992 May 15;206(1):1-6
MIP1 protein, S cerevisiae  EC 2.7.7.7   *DNA Polymerase I *Saccharomyces cerevisiae Proteins. Nucleic Acids Res 1991;19(4):955

To share this definition, click "text" (Facebook, Twitter) or "link" (blog, mail) then paste text link
Ads by Google

Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
Warning: the drugs or drug combinations referred to here may be similar or related, but are not be the same ones and may not have the same pharmacological action as other substances described on the same page or in the same row. Please refer to product monograph or to your doctor
This website is accredited by Health On the Net Foundation. Click to verify. We comply with the HONcode standard for trustworthy health information: verify here.
About Reference.MD Privacy