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DNA Polymerase II

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Definition: A DNA-dependent DNA polymerase characterized in E. coli and other lower organisms. It may be present in higher organisms and has an intrinsic molecular activity only 5% of that of DNA Polymerase I. This polymerase has 3'-5' exonuclease activity, is effective only on duplex DNA with gaps or single-strand ends of less than 100 nucleotides as template, and is inhibited by sulfhydryl reagents. EC 2.7.7.7.      Other names Pol II; DNA-Dependent DNA Polymerase II; DNA Polymerase epsilon; Polymerase epsilon, DNA; Polymerase II, DNA; DNA Dependent DNA Polymerase II
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
Dpb2 protein, S cerevisiae  EC 2.7.7.-   *DNA Polymerase II *Saccharomyces cerevisiae Proteins. Genetics 2008 Feb;178(2):633-47
POL2b protein, Arabidopsis  EC 2.7.7.-   *DNA Polymerase II *Arabidopsis Proteins Protein Subunits. Plant J 2005 Oct;44(2):223-36
POL2a protein, Arabidopsis  EC 2.7.7.-   *DNA Polymerase II *Arabidopsis Proteins Protein Subunits. Plant J 2005 Oct;44(2):223-36
DPB2 protein, Arabidopsis  0   *DNA-Binding Proteins *Arabidopsis Proteins DNA Polymerase II Protein Subunits. Plant J 2005 Oct;44(2):223-36
Dpb4 protein, S pombe  EC 2.7.7.7   *DNA Polymerase II *Schizosaccharomyces pombe Proteins. Nucleic Acids Res 2004;32(16):4945-53
Dpb3 protein, S pombe  EC 2.7.7.7   *DNA Polymerase II *Schizosaccharomyces pombe Proteins. Nucleic Acids Res 2004;32(16):4945-53
Pole protein, mouse  EC 2.7.7.-   *DNA Polymerase II.
POLE protein, human  EC 2.7.7.-   *DNA Polymerase II. Biochem J 1999 May 1;339( Pt 3):657-65
1-(2-deoxy-2-methylene-erthyro-pentofuranosyl)cytosine 5'-triphosphate  0   *Deoxycytosine Nucleotides DNA Polymerase II/antagonists & inhibitors. Biochem Pharmacol 1996 Oct 25;52(8):1279-85
PHYLPA 18  154482-94-7   *Cyclic P-Oxides *Lysophospholipids DNA Polymerase II/antagonists & inhibitors. Cell Struct Funct 1993 Jun;18(3):135-8
polB protein, E coli  0   *Escherichia coli Proteins DNA Polymerase II Escherichia coli. J Bacteriol 1992 May;174(10):3377-85
kelletinin A  112727-22-7 Ribitol, pentakis(4-hydroxybenzoate)  *Hydroxybenzoic Acids Ribitol/*analogs & derivatives DNA Polymerase II/antagonists & inhibitors. Experientia 1991;47(1):64
kelletinin I  87697-99-2 Benzoic acid, 4-hydroxy-, 1,2,3,4-butanetetrayl ester, (R*,S*)  *Hydroxybenzoic Acids Erythritol/*analogs & derivatives DNA Polymerase II/antagonists & inhibitors. Experientia 1991;47(1):64
NSC 613060  115952-49-3 4-Thiazolidinecarboxylic acid, 2-(2-((amino(bis(2-chloroethyl)amino)phosphinyl)oxy)ethyl)  *Nitrogen Mustard Compounds *Thiazolidines DNA Polymerase II/antagonists & inhibitors. J Cancer Res Clin Oncol 1988;114(3):309
NSC 612567  111606-88-3 2H-1,3-Thiazine-4-carboxylic acid, 2-(2-((amino(bis(2-chloroethyl)amino)phosphinyl)oxy)ethyl)tetrahydro  *Nitrogen Mustard Compounds *Thiazines DNA Polymerase II/antagonists & inhibitors. J Cancer Res Clin Oncol 1988;114(3):309
N(2)-(4-n-butylphenyl)-2'-deoxyguanosine 5'-triphosphate  87782-05-6   *Deoxyguanine Nucleotides DNA Polymerase II/antagonists & inhibitors.
Pharma Action Enzyme Inhibitors 		J Med Chem 1984;27(2):175
N(2)-(4-n-butylphenyl) 2'-deoxyguanosine  87781-96-2   Deoxyguanosine/*analogs & derivatives DNA Polymerase II/antagonists & inhibitors. J Med Chem 1984;27(2):175
3-deoxyaphidicolin  85483-00-7 8,11a-Methano-11aH-cyclohepta(a)naphthalene-4,9-dimethanol, tetradecahydro-9-hydroxy-4,11b-dimethyl-, (4R-(4alpha,4aalpha,6abeta,8beta,9beta,11abeta,11bbeta))  *Diterpenes DNA Polymerase II/antagonists & inhibitors. Nucleic Acids Res 1983;11(4):1197
acyclovir triphosphate  66341-18-2 triphosphoric acid, P-(2-((2-amino-1,6-dihydro-6-oxo-9H-purin-9-yl)methoxy)ethyl) ester  Acyclovir/*analogs & derivatives DNA Polymerase II/antagonists & inhibitors.
Pharma Action Antiviral Agents ; Enzyme Inhibitors 		J Biol Chem 1980;255(11):5120

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