DNA Polymerase III (definition)

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ψ	DNA Polymerase III

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Definition: A DNA-dependent DNA polymerase characterized in E. coli and other lower organisms but may be present in higher organisms. Use also for a more complex form of DNA polymerase III designated as DNA polymerase III* or pol III* which is 15 times more active biologically than DNA polymerase I in the synthesis of DNA. This polymerase has both 3'-5' and 5'-3' exonuclease activities, is inhibited by sulfhydryl reagents, and has the same template-primer dependence as pol II. EC 2.7.7.7.

Other names Pol III; DNA-Dependent DNA Polymerase III; DNA Polymerase delta; Polymerase delta, DNA; Polymerase III, DNA; DNA Dependent DNA Polymerase III

Substance	CAS Registry & name	Categories	Source
DNA polymerase delta p12 subunit, human	EC 2.7.7.-	*DNA Polymerase III Protein Subunits.	J Biol Chem 2000 Jun 23;275(25):18739-44
cdc27 protein, S pombe	0	DNA Polymerase III Schizosaccharomyces pombe Proteins.
holE protein, E coli	EC 2.7.7.-	DNA Polymerase III Escherichia coli Proteins.	J Biol Chem 1993 Jun 5;268(16):11785-91
HOT protein, bacteriophage P1	EC 2.7.7.-	DNA Polymerase III Viral Proteins.	Structure (Camb) 2004 Dec;12(12):2221-31
CDC2 protein, S cerevisiae	0	DNA Polymerase III Saccharomyces cerevisiae Proteins.
holC protein, E coli	EC 2.7.7.7	DNA Polymerase III Escherichia coli Proteins.	Nucleic Acids Res 2003 Aug 1;31(15):4434-40
dnaQ protein, E coli	EC 2.7.7.7	DNA Polymerase III Escherichia coli Proteins.
POLD3 protein, human	EC 2.7.7.-	*DNA Polymerase III Protein Subunits.	Nucleic Acids Res 1999 May 15;27(10):2108-14
POLD1 protein, human	EC 2.7.7.-	*DNA Polymerase III.	J Biol Chem 2001 Aug 10;276(32):29729-39
POLE3 protein, human	0	DNA Polymerase III DNA-Binding Proteins *Nucleoproteins.	EMBO J 2000 Jul 3;19(13):3377-87
Cdm1 protein, S pombe	EC 2.7.7.-	DNA Polymerase III Schizosaccharomyces pombe Proteins.	Curr Genet 1998 Oct;34(4):250-8
DnaX protein, Bacteria	0	Bacterial Proteins DNA Polymerase III Escherichia coli Proteins.	J Mol Biol 1996 Dec 6;264(3):412-25; Mol Gen Genet 1989 Apr;216(2-3):503-10
beta subunit, DNA polymerase III	EC 2.7.7.-	*DNA Polymerase III Escherichia coli Proteins.	J Biol Chem 1996 Aug 23;271(34):20699-704
HYS2 protein, S cerevisiae	EC 2.7.7.7	DNA Polymerase III Saccharomyces cerevisiae Proteins.	Nucleic Acids Res 1995 Sep 11;23(17):3493-500
DNA polymerase III, alpha subunit	EC 2.7.7.-	*DNA Polymerase III Escherichia coli Proteins.	J Bacteriol 1992 Jun;174(12):4166-8
DNA polymerase A	EC 2.7.7.-	*DNA Polymerase III.	Nucleic Acids Res 1990;18(16):4867
5-(2-bromovinyl)-1-arabinofuranosyluracil 5'-triphosphate	79551-90-9	*Arabinonucleotides DNA Polymerase III/antagonists & inhibitors.	Eur J Biochem 1990;190(3):463
transcription factor tau	EC 2.7.7.-	DNA Polymerase III Transcription Factors Saccharomyces cerevisiae Proteins Escherichia coli Proteins.	EMBO J 1984;3(2):343

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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