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DNA-Directed DNA Polymerase

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Definition: DNA-dependent DNA polymerases found in bacteria, animal and plant cells. During the replication process, these enzymes catalyze the addition of deoxyribonucleotide residues to the end of a DNA strand in the presence of DNA as template-primer. They also possess exonuclease activity and therefore function in DNA repair. EC 2.7.7.7.  GEN; prefer specifics   
Examples DNA Polymerase beta; DNA Polymerase I; DNA Polymerase II; DNA Polymerase III; RNA-Directed DNA Polymerase; Taq Polymerase 		Other names DNA-Dependent DNA Polymerases; DNA Polymerases; Polymerases, DNA-Dependent DNA; Polymerases, DNA; Polymerase, DNA-Directed DNA; Polymerase N3, DNA; DNA Polymerases, DNA-Dependent; DNA Polymerase, DNA-Directed; DNA Directed DNA Polymerase; DNA Dependent DNA Polymerases; DNA Polymerase N3
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
Polg-1 protein, C elegans  EC 2.7.7.-   *DNA-Directed DNA Polymerase *Caenorhabditis elegans Proteins. Biochim Biophys Acta. 2010 Sep;1802(9):765-73
DNA polymerase N, human  EC 2.7.7.7   *DNA-Directed DNA Polymerase. Biochemistry 2009 Dec 15;48(49):11817-24
POLGbeta protein, human  EC 2.7.7.7   *DNA-Directed DNA Polymerase. Nucleic Acids Res 2009 Sep;37(17):5701-13
REV3L protein, mouse  EC 2.7.7.7   *DNA-Directed DNA Polymerase *DNA-Binding Proteins. Mol Pharmacol. 2009 Oct;76(4):927-34
Polk protein, Xenopus  EC 2.7.7.7   *DNA-Directed DNA Polymerase *Xenopus Proteins. DNA Repair (Amst) 2005 Nov 21;4(11):1252-69
1-deoxyrubralactone  0   *Isocoumarins DNA-Directed DNA Polymerase/antagonists & inhibitors. Bioorg Med Chem 2008 Mar 15;16(6):2939-44
Pol32 protein, S cerevisiae  0   *DNA-Directed DNA Polymerase *Saccharomyces cerevisiae Proteins Protein Subunits. Nature 2007 Aug 16;448(7155):820-3
polV(R391) protein, E coli  EC 2.7.7.7   *DNA-Directed DNA Polymerase *Escherichia coli Proteins. Mol Microbiol 2007 Feb;63(3):797-810
TEBICHI protein, Arabidopsis  EC 2.7.7.-   *DNA-Directed DNA Polymerase *Arabidopsis Proteins DNA Helicases. Plant Cell 2006 Apr;18(4):879-92
REV7 protein, Arabidopsis  EC 2.7.7.-   *DNA-Directed DNA Polymerase *Arabidopsis Proteins. Plant Physiol 2005 Jun;138(2):870-81
POL4 protein, S pombe  EC 2.7.7.-   *DNA-Directed DNA Polymerase *Schizosaccharomyces pombe Proteins. Nucleic Acids Res 2005;33(15) (dup#3):4762-74
Polg protein, mouse  EC 2.7.7.-   *DNA-Directed DNA Polymerase.
POLK protein, Arabidopsis  EC 2.7.7.7   *DNA-Directed DNA Polymerase *Arabidopsis Proteins.
Polk protein, rat  EC 2.7.7.7   *DNA-Directed DNA Polymerase.
Polk protein, mouse  EC 2.7.7.7   *DNA-Directed DNA Polymerase.
PolD DNA Polymerase, Pyrococcus horikoshii  EC 2.7.7.7   *DNA-Directed DNA Polymerase *Archaeal Proteins. Biochem Soc Trans. 2004 Apr;32(Pt 2):245-9
cdc6 protein, S pombe  0   *Schizosaccharomyces pombe Proteins DNA-Directed DNA Polymerase.
TRF4 protein, S cerevisiae  EC 2.7.7.7   *DNA-Directed DNA Polymerase *Saccharomyces cerevisiae Proteins. Genes Dev 2004 Jun 1;18(11):1227-40
Rev3 protein, mouse  EC 2.7.7.-   *DNA-Directed DNA Polymerase. Genes Cells 2001 Feb;6(2):99-106
POL5 protein, S cerevisiae  EC 2.7.7.7   *DNA-Directed DNA Polymerase *Saccharomyces cerevisiae Proteins. Cell Cycle 2003 Mar-Apr;2(2):120-2
AtREV3 protein, Arabidopsis  EC 2.7.7.7   *DNA-Directed DNA Polymerase *Arabidopsis Proteins. Plant Cell 2003 Sep;15(9);2042-57
bacteriophage RB69 DNA polymerase  EC 2.7.7.7   *DNA-Directed DNA Polymerase *Viral Proteins. Nucleic Acids Res 2002 Aug 1;30(15):3341-8
PolC protein, bacteria  EC 2.7.7.-   *Bacterial Proteins *DNA-Directed DNA Polymerase. Mol Genet Genomics 2001 Dec;266(4):564-71
Dbh protein, Sulfolobus solfataricus  EC 2.7.7.-   *DNA-Directed DNA Polymerase *Archaeal Proteins. Mol Cell 2001 Aug;8(2):427-37; Mutat Res 1996 Oct 25;357(1-2):245-53
PolB P1 protein, Agrocybe aegerita  EC 2.7.7.-   *DNA-Directed DNA Polymerase *Fungal Proteins. Appl Environ Microbiol 2001 Apr;67(4):1739-43
PolB protein, Agrocybe aegerita  EC 2.7.7.-   *DNA-Directed DNA Polymerase *Fungal Proteins. Appl Environ Microbiol 2001 Apr;67(4):1739-43
DNA polymerase zeta  EC 2.7.7.-   DNA-Directed DNA Polymerase. Mutat Res 2001 Apr 4;485(3):237-53
Thy Pol-2 intein  EC 2.7.7.-   *DNA-Directed DNA Polymerase Polymerase Chain Reaction. Nucleic Acids Res. 2000 Nov 1;28(21):4391-6
DNA polymerase iota  EC 2.7.7.-   *DNA-Directed DNA Polymerase. Genes Dev 2000 Jul 1;14(13):1642-50
POLG protein, human  EC 2.7.7.-   *DNA-Directed DNA Polymerase. J Biol Chem 2000 Aug 11;275(32):24818-28
sculezonone B  0   *Polycyclic Hydrocarbons, Aromatic DNA-Directed DNA Polymerase/antagonists & inhibitors. J Nat Prod 2000 Mar;63(3):408-9
sculezonone A  0   *Polycyclic Hydrocarbons, Aromatic DNA-Directed DNA Polymerase/antagonists & inhibitors. J Nat Prod 2000 Mar;63(3):408-9
DNA polymerase mu  EC 2.7.7.-   *DNA-Directed DNA Polymerase. EMBO J 2000 Apr 3;19(7):1731-42
POLK protein, human  EC 2.7.7.7   *DNA-Directed DNA Polymerase Mutagenesis. Genes Cells 1999 Nov;4(11):607-18
DNA polymerase Tfu  EC 2.7.7.-   *DNA-Directed DNA Polymerase. J Biol Chem 2000 Jan 28;275(4):2335-41
polycitone A  0   *Alkaloids DNA-Directed DNA Polymerase/antagonists & inhibitors. Biochem J 1999 Nov 15;344 Pt 1:85-92
lucidenic lactone  0   *Terpenes DNA-Directed DNA Polymerase/antagonists & inhibitors. Bioorg Med Chem 1999 Sep;7(9):2047-52
lucidenic acid O  0   *Terpenes DNA-Directed DNA Polymerase/antagonists & inhibitors. Bioorg Med Chem 1999 Sep;7(9):2047-52
DNA polymerase V, E coli  EC 2.7.7.7   *DNA-Directed DNA Polymerase *Escherichia coli Proteins. Proc Natl Acad Sci U S A 1999 Aug 3;96(16):8919-24
DNA polymerase theta  EC 2.7.7.-   *DNA-Directed DNA Polymerase. Genomics 1999 Jul 1;59(1):90-6
REV3L protein, human  EC 2.7.7.7   *DNA-Directed DNA Polymerase *DNA-Binding Proteins. Mutat Res 1999 Mar10;433(2):89-98
Pwo polymerase  EC 2.7.7.-   *DNA-Directed DNA Polymerase. Protein Expr Purif 1998 Oct;14(1):131-8
PAPD7 protein, human  EC 2.7.7.7   *Chromosomal Proteins, Non-Histone *DNA-Directed DNA Polymerase DNA Repair. J Biol Chem 1999 Mar 12;274(11):7302-8
N(2)-(4-n-butylphenyl)-2'--deoxyguanosine 5'-imidotriphosphate  0   *Deoxyguanine Nucleotides *Guanylyl Imidodiphosphate DNA-Directed DNA Polymerase/antagonists & inhibitors. Nucleosides Nucleotides 1998 Aug;17(8):1505-13
Rad30 protein  EC 2.7.7.7   *DNA-Directed DNA Polymerase DNA Repair Xeroderma Pigmentosum. Mol Gen Genet 1998 Apr;257(6):686-92
1-O-(6'-sulfo-alpha-D-glucopyranosyl)-2,3-di-O-phytanyl-sn-glycerol  0   *Glycolipids DNA-Directed DNA Polymerase/antagonists & inhibitors. Int J Cancer 1998 May 18;76(4):512-8
corylifolin  0   *Phenols DNA Topoisomerases, Type II/antagonists & inhibitors DNA-Directed DNA Polymerase/antagonists & inhibitors. J Nat Prod 1998 Mar;61(3):362-6
DNA polymerase X  EC 2.7.7.-   *DNA-Directed DNA Polymerase DNA Repair. J Biol Chem 1997 Dec 5;272(49):30899-910
UL54 protein, Human herpesvirus 5  0   *DNA-Directed DNA Polymerase *Viral Proteins Catalytic Domain. Protein Expr Purif 1997 Nov;11(2):209-18
DyNAzyme polymerase  EC 2.7.7.-   *DNA-Directed DNA Polymerase. Biotechniques 1997 Sep;23(3):380-2
DNA synthesome  EC 2.7.7.-   *DNA-Directed DNA Polymerase *Multienzyme Complexes. Leuk Res 1997 Jun;21(6):501-12
2-hexaprenylhydroquinone  0   *Terpenes DNA-Directed DNA Polymerase/antagonists & inhibitors. Biochem J 1997 Jun 15;324(Pt 3):721-7
Pyrococcus sp GB-D DNA polymerase  EC 2.7.7.-   *DNA-Directed DNA Polymerase. Methods Mol Biol 1997;67:209-18
DNA polymerase gamma  EC 2.7.7.-   *DNA-Directed DNA Polymerase Phosphorus-Oxygen Lyases.
T7C-45 protein-ANBD  0   *Oxadiazoles *Viral Proteins DNA-Directed DNA Polymerase Trans-Activators. J Biol Chem 1996 Nov 8;271(45):28045-51
T7C-45 protein, Bacteriophage T4  0   *Trans-Activators DNA-Directed DNA Polymerase Bacteriophage T4. J Biol Chem 1996 Nov 8;271(45):28045-51
RC-1 recombination protein complex  0   *DNA-Directed DNA Polymerase *Endodeoxyribonucleases *Multienzyme Complexes *DNA Ligases. EMBO J 1996 Aug 1;15(15):4061-8
DNA polymerase, Thermus thermophilus  EC 2.7.7.-   *DNA-Directed DNA Polymerase Exodeoxyribonucleases Ribonuclease H. Biochemistry 1995 Apr 18;34(15):4994-5002
REV3 protein, S cerevisiae  EC 2.7.7.7   *DNA-Directed DNA Polymerase *Saccharomyces cerevisiae Proteins. Mol Cell Biol 1995 Apr;15(4):2173-9
penciclovir triphosphate  0   Acyclovir/*analogs & derivatives DNA-Directed DNA Polymerase/antagonists & inhibitors. Biochemistry 1995 Feb 28;34(8):2504-10
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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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