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Dynorphins

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Definition: A class of opioid peptides including dynorphin A, dynorphin B, and smaller fragments of these peptides. Dynorphins prefer kappa-opioid receptors (RECEPTORS, OPIOID, KAPPA) and have been shown to play a role as central nervous system transmitters.     
Pharmacological Action Neurotransmitter Agents
See Also Receptors, Opioid, kappa 		Other names Dynorphin A (1-17); Dynorphin A; Dynorphin (1-17); Dynorphin
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
dynorphin A (1-13)amide, N-Met-Tyr(1)  0   *Dynorphins. AAPS J 2004;6(4):e36
dynorphin A (1-13), N-Met-Tyr(1)  0   *Dynorphins. AAPS J 2004;6(4):e36
dynorphin A-(1-11)-NH2, Nalpha-benzylTyr(1)-cyclo(Asp(5)-Dap(8))  0   *Dynorphins *Peptide Fragments Receptors, Opioid, kappa/antagonists & inhibitors. J Med Chem 2005 Jul 14;48(14):4500-3
dynorphin A-(1-11)amide, cyclo(N,5)(Trp(3)-Trp(4)-Glu(5))-  0   *Dynorphins *Peptides, Cyclic. J Med Chem 2003 Apr 10;46(8):1279-82
arodyn  0   *Dynorphins. J Med Chem 2002 Dec 19;45(26):5617-9
dynorphin A (1-11)-amide, Pro(3)  0   *Dynorphins *Peptide Fragments. J Med Chem 2000 Jul 13;43(14):2698-702
dynorphin A (2-12)  0   *Dynorphins *Peptide Fragments. J Pharm Biomed Anal 1997 Sep;16(1):101-9
dynorphin A, Ala(2)-des-Gly(3)  0   *Dynorphins. Bioorg Med Chem 1998 Jan;6(1):57-62
dynorphin A, Dmt(1)-Tic(2)  0   *Dynorphins *Tetrahydroisoquinolines. Bioorg Med Chem 1998 Jan;6(1):57-62
dynorphin A (1-11)-amide  0   *Dynorphins *Peptide Fragments. Bioorg Med Chem 1998 Jan;6(1):57-62
dynorphin A (6-12)  0   *Dynorphins *Peptide Fragments. Peptides 1995;16(3):547-50
dynorphin B (1-13)  0   *Dynorphins *Peptide Fragments. Brain Res 1994 Nov 21;664(1-2):49-53
dynorphin A (1-13), Asn(2)-Trp(4)  143407-24-3   *Dynorphins *Peptide Fragments. Int J Pept Protein Res 1993 Jul;42(1):58-63
dynorphin (2-17)  83608-80-4   *Dynorphins *Peptide Fragments. Neuropeptides 1989 Jul;14(1):45-50
dynorphin A, desTyr(1)-Gly(2)  0   *Dynorphins. J Pharmacol Exp Ther 1993 Jul;266(1):121-4
dynorphin A amide (1-13), 4-aminocyclohexylcarbonyl(2-3)  0   *Dynorphins *Peptide Fragments. J Med Chem 1993 Jun 25;36(13):1921-2
3-nitro-2-pyridinesulfenyl dynorphin derivative  139883-41-3   *Dynorphins. Arch Int Pharmacodyn Ther 1991 Sep-Oct;313:33-46
dynorphin A ethylamide (1-8), N-methyl-Tyr(1)-4-nitro-Phe(4)-N-methyl-Arg(7)-Leu(8)  103614-23-9   *Dynorphins *Peptide Fragments. Eur J Pharmacol 1991 Aug 29;201(2-3):185-9
dynorphin A (1-13), Tyr(14)-Leu(15)-Phe(16)-Asn(17)-Gly(18)-Pro(19)  134646-23-4   *Dynorphins. Eur J Pharmacol 1991;196(2):161
dynorphin B (5-9)  132733-02-9 L-Phenylalanine, N-(N2-(N2-(N2-L-leucyl-L-arginyl)-L-arginyl)-L-glutaminyl)  *Dynorphins *Peptide Fragments. Biomed Environ Mass Spectrom 1990;19(13):819
dynorphin A ethylamide (1-9), MeTyr(1)-MeArg(7)-Leu(8)  103614-28-4   *Dynorphins *Peptide Fragments. Chem Pharm Bull (Tokyo) 1990;38(8):2274
dynorphin A amide (1-9), Cys(2)-Cys(5)-MeArg(7)-Leu(8)  103614-06-8   *Dynorphins *Peptide Fragments. Chem Pharm Bull (Tokyo) 1990;38(8):2274
dynorphin (1-24)  83663-53-0   *Dynorphins. Chem Pharm Bull (Tokyo) 1989;37(10):2631
E 2078  103613-84-9 D-Leucinamide, N-methyl-L-tyrosylglycylglycyl-L-phenylalanyl-L-leucyl-L-arginyl-N2-methyl-L-arginyl-N-ethyl  *Dynorphins *Peptide Fragments.
Pharma Action Diuretics ; Analgesics, Non-Narcotic 		J Pharmacol Exp Ther 1989;251(1):351
dynorphin A amide (1-13), biocytin(13)  119622-27-4   *Dynorphins Biotin/*analogs & derivatives. Pharm Res 1988;5(12):790
dynorphin amide (1-13), Ala(2)-(5-F-Phe)(4)  111846-43-6   *Dynorphins *Peptide Fragments. Peptides 1987;8(5):811
dynorphin A (1-13), Ala(2)-Trp(4)  104746-05-6   *Dynorphins *Peptide Fragments. Can J Physiol Pharmacol 1986;64(6):673
dynorphin bridge peptide  0   *Dynorphins. Neuropeptides 1985;5(4-6):501
dynorphin (1-32)  83328-95-4   *Dynorphins. Neuropeptides 1985;5(4-6):425
dynorphin (3-13)  89202-80-2   *Dynorphins *Peptide Fragments. Neuropeptides 1985;5(4-6):307
dynorphin (1-11)  79985-34-5 alpha-Neoendorphin (pig), 7-L-arginine-8-L-isoleucine-8a-endo-L-arginine  *Dynorphins *Peptide Fragments. Eur J Pharmacol 1984;106(2):457
dynorphin (1-11), Pro(10)  94596-26-6 alpha-Neoendorphin, 7-L-arginine-8-L-isoleucine-8a-endo-L-arginine-9-D-proline-, (2S-(2alpha,5alpha,6beta(S*)))  *Dynorphins *Peptide Fragments. Eur J Pharmacol 1984:106(2):457
dynorphin B (1-29)  84376-30-7   *Dynorphins *Peptide Fragments. Neuropeptides 1984;4(5):369
PL017-dynorphin A (6-17)  0   *Dynorphins *Peptide Fragments. Mol Pharmacol 1984;26(3):484
dynorphin A (1-9)  77259-54-2 L-Arginine, N2-(N-(N2-(N2-(N-(N-(N-(N-L-tyrosylglycyl)glycyl)-L-phenylalanyl)-L-leucyl)-L-arginyl)-L-arginyl)-L-isoleucyl)  *Dynorphins *Peptide Fragments. Life Sci 1983;33 suppl 1:283
dynorphin amide (1-10)  79985-49-2 alpha-Neoendorphin, 7-L-arginine-8-L-isoleucine-9-L-arginine-10-L-prolinamide  *Dynorphins *Peptide Fragments. Eur J Pharmacol 1983;96(1-2):117
dynorphin (1-12)  79985-35-6   *Dynorphins *Peptide Fragments. Life Sci 1983;32(8):865
dynorphin A, desTyr(1)-desTrp(14)-desAsp(15)-desAsn(16)-desGlu(17)  84211-35-8 Dynorphin A, 1-de-L-tyrosine-14-de-L-tryptophan-15-de-L-aspartic acid-16-de-L-asparagine-17-de-L-glutamine  *Dynorphins *Peptide Fragments. Peptides 1983 Nov-Dec;4(6):833-6
pre-prodynorphin  0   *Dynorphins *Protein Precursors. Life Sci 1982;31(16-17):1645
rimorphin  83335-41-5 Dynorphin B  *Dynorphins *Endorphins. Proc Natl Acad Sci USA 1982;79(21):6480
dynorphin (1-11), Ala(2)  75491-15-5 L-Lysine, N2-(1-(N2-(N-(N2-(N2-(N-(N-(N-(N-L-tyrosyl-D-alanyl)glycyl)-L-phenylalanyl)-L-leucyl)-L-arginyl)-L-arginyl)-L-isoleucyl)-L-arginyl)-L-prolyl)  *Dynorphins *Peptide Fragments. Life Sci 1980;27(10):883
dynorphin (1-13)  72957-38-1   *Dynorphins *Peptide Fragments.
Pharma Action Analgesics, Opioid ; Narcotics 		Life Sci 1980;27(10):883
dynorphin (1-8)  75790-53-3 alpha-Neoendorphin, 7-L-arginine-8-L-isoleucine-9-de-L-proline-10-de-L-lysine  *Dynorphins *Peptide Fragments Hypothalamic Hormones. Biochem Biophys Res Commun 1980;95(4):1475; Biochem Biophys Res Commun 1981;102(1):197

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