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Ellipticines

More information in Books or onNLM PubMed
Definition: Pyrido-CARBAZOLES originally discovered in the bark of OCHROSIA ELLIPTICA. They inhibit DNA and RNA synthesis and have immunosuppressive properties.     
Pharmacological Action Antineoplastic Agents, Phytogenic; Immunosuppressive Agents
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
8-methyl-4-(3-diethylaminopropylamino)pyrimido((4',5':4,5)selenolo(2,3-b)quinoline)  0   *Ellipticines *Organoselenium Compounds. Invest New Drugs. 2011 Aug;29(4):523-33
3-(9-methoxy-5,11-dimethylpyrido(4,3-b)carbazol-6-yl)propan-1-amine  0   *Ellipticines. Cancer Biol Ther 2008 Dec;7(12):2039-46
NSC 338258  0   *Ellipticines. Mol Cancer Ther 2008 Mar;7(3):500-9
13-hydroxyellipticine  0   *Ellipticines. Int J Cancer 2007 Jan 15;120(2):243-51
12-hydroxyellipticine  0   *Ellipticines. Int J Cancer 2007 Jan 15;120(2):243-51
9-methoxy-2-methylellipticinium acetate  0   *Ellipticines. Br J Cancer 2004 Nov 15;91(10);1808-12
S30972-1  0   *Ellipticines. Clin Cancer Res. 2000 Sep;6(9):3774-82
(1-(3-(N-(3-aminopropyl)-N-methylamino)propyl)amino-9-methoxy-5,11-dimethyl-6H-pyrido(4,3-b)carbazole)-Ala-Leu-Ala-Leu-Ala-Su-H-Ala-Try-Gly-Trp-Nle-Asp-Phe-NH2  0   *Ellipticines *Oligopeptides. Proc Natl Acad Sci U S A 1998 Sep 29;95(20):11520-5
9-chloro-2-methylellipticinium acetate  0   *Ellipticines. J Cancer Res Clin Oncol 1998 Jan;124(1):19-26
S 16020-2  0   *Ellipticines. Cancer Chemother Pharmacol 1996;38(6):513-21
distel(2+)  159506-80-6   *Distamycins *Ellipticines. Biochem Pharmacol 1995 Jul 31;50(3):424-8
9-methoxy-N(2)-methylellipticinium  70173-20-5   *Ellipticines. Biochem Pharmacol 1995 Jan 6;49(1):23-32
2,4-dimethyl-6H-pyrido(3,2-b)carbazole  155136-72-4   *Ellipticines. Pharmazie 1993 Nov;48(11):817-20
9-oleyloxy-N(2)-methylellipticinium oleate  0   *Ellipticines. Br J Cancer 1993 Aug;68(2):319-26
4-((((9-methoxyellipticin-2-yl)pentyl)carbonyl)amino)phenyl-tris(4N-methylpyridiniumyl)porphyrinato-zinc(II)tetraacetate  145247-77-4   *Ellipticines *Porphyrins. J Photochem Photobiol B 1992 Oct 15;16(1):47-59
4-(((((9-methoxyellipticin-2-yl)pentyl)carbonyl)amino)propoxy)phenyl-tris(4N-methylpyridiniumyl)porphyrinato-zinc(II)tetraacetate  0   *Ellipticines *Porphyrins. J Photochem Photobiol B 1992 Oct 15;16(1):47-59
Distel  144236-70-4 1H-Pyrrole-2-carboxamide, 4-(((4-(formylamino)-1-methyl-1H-pyrrol-2-yl)carbonyl)amino)-N-(5-(((3-((9-methoxy-5,11-dimethyl-6H-pyrido(4,3-b)carbazol-1-yl)amino)propyl)amino)carbonyl)-1-methyl-1H-pyrrol-3-yl)-1-methyl  *Distamycins *Ellipticines Deoxyribonuclease I/antagonists & inhibitors. Biochemistry 1992 Dec 15;31(49):12385-96
ellipticine-polyaldehyde dextran  0   *Dextrans *Ellipticines *Hydrazones. Bioconjug Chem 1990;1(1):77
1-(amino-3-propylamino)-5,11-dimethyl-9-methoxy-6H-pyrido(4,3-b)carbazole  74861-72-6   *Ellipticines. Nucleic Acids Res 1990;18(21):6283
detalliptinium  81531-57-9 6H-Pyrido(4,3-b)carbazolium, 2-(2-(diethylamino)ethyl)-9-hydroxy-5,11-dimethyl  *Ellipticines. Biochem Pharmacol 1989;38(13):2077
7H-pyrido(4,3-c)carbazole  205-29-8   *Ellipticines. Biopolymers 1989;28(4):835
octathymidylate-9-aminoellipticine  117153-31-8   *Ellipticines. Biochem Biophys Res Commun 1988;152(1):56
2-methyl-6-propylellipticine  114752-50-0   *Ellipticines. Anticancer Res 1988;8(1):191
2,6-dimethylellipticine  99759-40-7   *Ellipticines. Anticancer Res 1988;8(1):191
7-hydroxyellipticine  67484-39-3   *Ellipticines. Eur J Biochem 1988;172(3):585
1,4-dihydro-4-oxo-2,5,11-trimethyl-6H-pyrido(3,2-b)carbazole  111249-53-7   *Ellipticines. Chem Pharm Bull (Tokyo) 1987;35(5):1724
N(2),N(6)-dimethyl-9-hydroxyellipticinium  69467-90-9   *Ellipticines. Biochem Pharmacol 1987;36(16):2559; Comptes Rendes Serie D 281(18):1365;1975
2-isopropyl-7,10,12-trimethyl-6H-(1,3)oxazolo(5,4c)pyrido(3,4-g)carbazole  104393-91-1   *Ellipticines. Biochem Biophys Res Commun 1986;138(2):505
BR 76  65222-36-8   *Ellipticines. Biochem Pharmacol 1986;35(13):2087
13-oxoellipticine  77251-57-1   *Ellipticines. J Nat Prod 1986;49(3):449
10-((1-carboxy-2-methylpropylidene)amino)-9-hydroxy-2-methylellipticinium  89683-26-1   *Ellipticines. Biochimie 1985;67(3-4):327
retelliptine  72238-02-9   *Ellipticines. Drug Metab Dispos 1985;13(4):497
N,N-dimethyltetrahydroellipticine  87988-85-0 1H-Pyrido(4,3-b)carbazolium, 2,3,4,6-tetrahydro-2,2,5,11-tetramethyl-, hydroxide  *Ellipticines. An Acad Bras Cienc 1983;55(2):189
9-hydroxy-2-methylolivacinium  81531-67-1 6H-Pyrido(4,3-b)carbazolium, 9-hydroxy-1,2,5-trimethyl-, acetate (salt)  *Ellipticines. Xenobiotica 1983;13(5):303
9-aminoellipticine  54779-53-2   *Ellipticines. Biochem Pharmacol 1983;32(14):2189
8-nitroellipticine  82212-22-4 6H-Pyrido(4,3-b)carbazole, 5,11-dimethyl-8-nitro  *Ellipticines. Farmaco (Sci) 1982;37(5):283
ellipticine  519-23-3   *Ellipticines.
Pharma Action Antineoplastic Agents ; Uncoupling Agents 		Eur J Cancer Clin Oncol 1981;17(10):1097
elliptinium  58337-34-1 6H-Pyrido(4,3-b)carbazolium, 9-hydroxy-2,5,11-trimethyl  *Ellipticines.
Pharma Action Antineoplastic Agents ; Intercalating Agents 		Br J Haematol 1980 46(4):549; Cancer Treat Rep 1980;64(8-9):879
2-methylellipticinium  69467-91-0   *Ellipticines. Biochem Biophys Res Commun 1980;961):363
olivacine  484-49-1 1,5-dimethyl-6H-pyrido(4,3-b)carbazole  *Ellipticines. Exp Parasitol 45(2):151;1978; J Chem Soc (Perkin I)21:2102;1975
9-hydroxyellipticine  51131-85-2 NSC 210717  *Ellipticines.
Pharma Action Antimetabolites, Antineoplastic 		Biochemistry 15(14):2964;1976; Cancer Res 36(9):3067;1976; Chem Biol Interact 1979;27(2-3):269; CR Acad Sci (D) (Paris) 278(10):1437;1974; Proc Natl Acad Sci USA 71(12):5078;1974
9-methoxyellipticine  10371-86-5   *Ellipticines. Ann Pharm Fr 30(2):85;1972; J Nat Prod 1979;42(6):643

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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