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Endodeoxyribonucleases

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Definition: A group of enzymes catalyzing the endonucleolytic cleavage of DNA. They include members of EC 3.1.21.-, EC 3.1.22.-, EC 3.1.23.- (DNA RESTRICTION ENZYMES), EC 3.1.24.- (DNA RESTRICTION ENZYMES), and EC 3.1.25.-.     
Examples Deoxyribonuclease (Pyrimidine Dimer); Deoxyribonuclease I; Deoxyribonuclease IV (Phage T4-Induced); DNA Restriction Enzymes; Holliday Junction Resolvases; Micrococcal Nuclease; Single-Strand Specific DNA and RNA Endonucleases
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
SLX1 protein, Drosophila  EC 3.1.-   *Endodeoxyribonucleases *Drosophila Proteins. Mol Cell. 2009 Jul 10;35(1):128-35.
Mms4 protein, Drosophila  EC 3.1.-   *Endodeoxyribonucleases *Drosophila Proteins. Genetics. 2007 Aug;176(4):1993-2001.
YgbT protein, E coli  EC 3.1.-   *Endodeoxyribonucleases. Mol Microbiol 2011 Jan;79(2):484-502
Nth1 protein, rat  EC 3.1.-   *Endodeoxyribonucleases. Mol Cell Biochem 2010 May;338(1-2):233-9
NEIL3 protein, mouse  EC 3.1.-   *Endodeoxyribonucleases. J Biochem 2005 Dec;138(6):763-72
XPF protein, Arabidopsis  EC 3.1.-   *Endodeoxyribonucleases *Arabidopsis Proteins. Plant Physiol 2000 Oct;124(2):579-86
CRN-4 protein, C elegans  EC 3.1.-   *Endodeoxyribonucleases *Caenorhabditis elegans Proteins. Mol Cell Biol 2009 Jan;29(2):448-57
Spo11 protein, S cerevisiae  EC 3.1.-   *Endodeoxyribonucleases *Saccharomyces cerevisiae Proteins. Proc Natl Acad Sci U S A 2007 Mar 6;104(10):3955-60
Slx4 protein, S pombe  EC 3.1.-   *Endodeoxyribonucleases *Schizosaccharomyces pombe Proteins. Mol Biol Cell 2004 Jan;15(1):71-80
Slx1 protein, S pombe  EC 3.1.-   *Endodeoxyribonucleases *Schizosaccharomyces pombe Proteins. Mol Biol Cell 2004 Jan;15(1):71-80
Eme1 protein, human  EC 3.1.-   *Endodeoxyribonucleases. Nucleic Acids Res 2006;34(3):880-92
SLX1 protein, S cerevisiae  EC 3.1.-   *Endodeoxyribonucleases *Saccharomyces cerevisiae Proteins DNA Repair. Biochem J 2005 Oct 15;391(Pt 2):325-33
Dclre1a protein, mouse  EC 3.1.-   *Endodeoxyribonucleases. Mol Cell Biol 2000 Jul;20(13):10071-8
p4 protein, bacteriophage phi 13  EC 3.1.-   *Endodeoxyribonucleases *Viral Proteins. Acta Crystallogr D Biol Crystallogr 2005 Sep;61(Pt 9):1238-44
SLX4 protein, S cerevisiae  EC 3.1.-   *Endodeoxyribonucleases *Saccharomyces cerevisiae Proteins. Genetics 2005 Jun;170(2):591-600
Tat-D nuclease, S cerevisiae  EC 3.1.-   *Endodeoxyribonucleases *Exodeoxyribonucleases *Saccharomyces cerevisiae Proteins. J Biol Chem 2005 Apr 15;280(15):15370-9
Dna2 protein, C elegans  0   *DNA Helicases *Endodeoxyribonucleases *Caenorhabditis elegans Proteins Multienzyme Complexes. Nucleic Acids Res 2005;33(4):1372-83
Rad50 protein, Drosophila  EC 3.1.-   *Endodeoxyribonucleases *Exodeoxyribonucleases *Drosophila Proteins DNA Repair Enzymes. Curr Biol 2004 Aug 10;14(15):1360-6
Mre11 protein, Drosophila  EC 3.1.-   *Endodeoxyribonucleases *Drosophila Proteins DNA Repair Enzymes. Curr Biol 2004 Aug 10;14(15):1348-53
Mbd4 protein, mouse  EC 3.2.2.-   *Endodeoxyribonucleases DNA Repair Base Pair Mismatch.
SbcC protein, E coli  0   *Deoxyribonucleases *Escherichia coli Proteins Endodeoxyribonucleases Exodeoxyribonucleases Zinc Fingers.
DNASE1L3 protein, human  EC 3.1.-   *Endodeoxyribonucleases.
Eme1 protein, mouse  EC 3.1.-   *Endodeoxyribonucleases. EMBO J 2003 Nov 17;22(22):6137-47
CRN-1 protein, C elegans  EC 3.1.-   *Endodeoxyribonucleases *Caenorhabditis elegans Proteins. EMBO J. 2003 Jul 1;22(13):3451-60
YqgF protein, E coli  EC 3.1.21.-   *Endodeoxyribonucleases *Escherichia coli Proteins Recombination, Genetic. J Biomol NMR 2002 Jun;23(2):159-60
Cho protein, E coli  EC 3.1.25.1   *Endodeoxyribonucleases *Escherichia coli Proteins DNA Repair. Proc Natl Acad Sci U S A 2002 Feb 5;99(3):1467-72
ResT protein, Borrelia  EC 3.1.22.-   *Bacterial Proteins *Endodeoxyribonucleases. Mol Cell 2002 Jan;9(1):195-201
Rad2 protein, S pombe  EC 3.1.25.-   *Endodeoxyribonucleases. J Mol Biol 2001 Oct 19;313(2):241-53
Rad13 protein, S pombe  EC 3.1.25.-   *Endodeoxyribonucleases Schizosaccharomyces. J Mol Biol 2001 Oct 18;313(2):241-53
Pa-MIG protein, Pyrobaculum aerophilum  EC 3.1.21-   *Endodeoxyribonucleases *Archaeal Proteins. J Biol Chem 2001 Aug 10;276(32):29979-86
I-BmoI endonuclease  EC 3.1.-   *Endodeoxyribonucleases. Proc Natl Acad Sci U S A 2001 Jul 3;98(14):7898-903
terminase, Tupaiid herpesvirus  EC 3.1.-   *Endodeoxyribonucleases *Viral Proteins. Virus Res 2001 Apr;74(1-2):27-38
cleavase VIII  EC 3.1.21.-   *Endodeoxyribonucleases. Diagn Mol Pathol 2000 Sep;9(3):158-64
bacteriophage SPP1 terminase  0   *Adenosine Triphosphatases *Endodeoxyribonucleases. J Biol Chem 2000 Nov 10;275(45):35311-9
Mre11 protein, archaeal  EC 3.1.-   *Endodeoxyribonucleases *Exodeoxyribonucleases *Archaeal Proteins. J Bacteriol 2000 Nov;182(21):6036-41
Rad50 protein, archaeal  EC 3.1.-   *Endodeoxyribonucleases *Exodeoxyribonucleases *Archaeal Proteins. J Bacteriol 2000 Nov;182(21):6036-41
PI-PfuI intein  EC 3.1.-   *Endodeoxyribonucleases. Nucleic Acids Res 1999 Nov 1;27(21):4167-74
meiotic recombination protein SPO11  EC 3.1.-   *Endodeoxyribonucleases. Genomics 1999 Oct 15;61(2):156-69
Kpn2I protein, Klebsiella pneumoniae  EC 3.1.21.-   *Bacterial Proteins *Endodeoxyribonucleases. Nucleic Acids Res 1999 Nov 1;27(21):4228-34
dnaG protein, E coli  EC 3.1.-   *Endodeoxyribonucleases *Exodeoxyribonucleases *Escherichia coli Proteins. J Bacteriol 1999 Oct;181(19):6010-8
MobM protein, bacteria  EC 3.1.25.-   *Bacterial Proteins *Endodeoxyribonucleases. J Mol Biol 1997 Mar 7;266(4):688-702
DnsH protein, Aeromonas hydrophila  EC 3.1.21.-   *Bacterial Proteins *Endodeoxyribonucleases. FEMS Microbiol Lett 1999 Apr 1;173(1):41-6
cleavase  EC 3.1.21.-   *Endodeoxyribonucleases. Genet Anal 1999 Feb;14(5-6):181-6
MBD4 protein, human  EC 3.1.-   *Endodeoxyribonucleases Base Pair Mismatch. Proc Natl Acad Sci U S A 1999 Mar 30;96(7):3969-74
Dnase1l3 protein, mouse  EC 3.1.-   *Endodeoxyribonucleases. Gene 1998 Jul 30;215(2):291-301; Genomics 1997 Jun 15;42(3):507-13
gene V protein T48C  0   *DNA-Binding Proteins *Endodeoxyribonucleases. Chem Biol 1998 May;5(5):283-92
endonuclease S  EC 3.1.-   *Endodeoxyribonucleases. Nucleic Acids Symp Ser 1997;(37):135-6
apoptotic nuclease Mr 34,000  EC 3.1.21.-   *Endodeoxyribonucleases. Cancer Res 1998 Jun 15;58(12):2576-82
DdbP1 protein, Drosophila  EC 3.1.25.1   *DNA-Binding Proteins *Endodeoxyribonucleases *Drosophila Proteins. Biochim Biophys Acta 1998 Apr 29;1397(2):180-8
mitochondrial oxidative damage endonuclease  EC 3.1.25.-   *Endodeoxyribonucleases DNA Repair. J Biol Chem 1997 Oct 24;272(43):27338-44
cce1 protein, S pombe  EC 3.1.21.-   *Endodeoxyribonucleases *Schizosaccharomyces pombe Proteins. Mol Cell Biol 1997 Nov;17(11):6465-71
Ai2a endonuclease, Dictyostelium  EC 3.1.-   *Endodeoxyribonucleases *Protozoan Proteins. Gene 1997 May 20;191(1):115-21
endodeoxyribonuclease I-PorI  EC 3.1.-   *Endodeoxyribonucleases. EMBO J 1997 Jun 2;16(11):3272-81
NuiA protein, Anabaena  0   *Bacterial Proteins Endodeoxyribonucleases/antagonists & inhibitors Endoribonucleases/antagonists & inhibitors. J Mol Biol 1997 May 9;268(3):589-98
deoxyribonuclease gamma  EC 3.1.-   *Endodeoxyribonucleases. Biochem Biophys Res Commun 1997 Feb 13;231(2):305-8
uvde protein, S pombe  EC 3.1.25.-   *Endodeoxyribonucleases *Schizosaccharomyces pombe Proteins DNA Repair Schizosaccharomyces Ultraviolet Rays. Nucleic Acids Res 1994 Aug 11;22(15):3026-32
terminase, phage T4  EC 3.1.-   *Endodeoxyribonucleases Viral Proteins. J Biol Chem 1997 Feb 7;272(6):3495-501
SegE endonuclease  EC 3.1.25.-   *Endodeoxyribonucleases. Mol Biol (Mosk) 1996 Nov-Dec;30(6):1307-15
N.BstSE nickase  EC 3.1.21.-   *Endodeoxyribonucleases. Mol Biol (Mosk) 1996 Nov-Dec;30(9):1261-7
CeAPN1 protein, C elegans  EC 4.2.99.18   *Endodeoxyribonucleases *Caenorhabditis elegans Proteins. Gene 1996 Nov 14;179(2):291-3
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