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Endonucleases

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Definition: Enzymes that catalyze the hydrolysis of the internal bonds and thereby the formation of polynucleotides or oligonucleotides from ribo- or deoxyribonucleotide chains. EC 3.1.-.     
Examples Endodeoxyribonucleases; Endoribonucleases
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
SHOC1 protein, Arabidopsis  EC 3.1.-   *Endonucleases *Arabidopsis Proteins. Curr Biol. 2008 Sep 23;18(18):1432-7.
YdaL protein, E coli  EC 3.1.-   *Endonucleases *Escherichia coli Proteins DNA-Binding Proteins. J Struct Biol 2011 May;174(2):282-9
NTH-1 protein, C elegans  EC 3.1.-   *Endonucleases *Caenorhabditis elegans. Aging (Albany NY). 2010 Mar;2(3):133-59
SLX1 protein, human  EC 3.1.-   *Endonucleases DNA Repair. Cell 2009 Jul 10;138(1):78-89
IRE-1 protein, C elegans  EC 2.7.11.1. -   *Protein-Serine-Threonine Kinases *Caenorhabditis elegans Proteins Endonucleases Endoplasmic Reticulum Membrane Proteins. Cell Metab. 2009 May;9(5) :440-8
Arp protein, Arabidopsis  EC 3.1.-   *Endonucleases. PLoS ONE 2009;4(1):e4297
Ape2 protein, Arabidopsis  EC 3.1.-   *Endonucleases *Arabidopsis Proteins. PLoS ONE 2009;4(1):e4297
Ape1L protein, Arabidopsis  EC 3.1.-   *Endonucleases *Arabidopsis Proteins. PLoS ONE 2009;4(1):e4297
DNA2 protein, Xenopus  0   *DNA Helicases *Endonucleases *Xenopus Proteins. Nucleic Acids Res 2008 Nov;36(19):6091-100
ORF2 protein, human  0   *Endonucleases *RNA-Directed DNA Polymerase. Genomics 1987 Oct;1(2):113-25
ENDOGL1 protein, human  EC 3.1.-   *Endonucleases. Diabetologia 2007 Jun;50(6):1218-27
MSH1 protein, Arabidopsis  EC 3.6.1.3   *Arabidopsis Proteins *MutS DNA Mismatch-Binding Protein Endonucleases. Proc Natl Acad Sci U S A 2003 May 13;100(10):5968-73
MUS81 protein, Arabidopsis  EC 3.1.-   *Endonucleases *Arabidopsis Proteins DNA Repair. Nucleic Acids Res 2006;34(16):4438-48
Utp24 protein, S cerevisiae  0   *Nuclear Proteins *Saccharomyces cerevisiae Proteins Endonucleases. Proc Natl Acad Sci U S A 2006 Jun 20;103(25):9464-9
Ercc1 protein, mouse  EC 3.1.-   *DNA-Binding Proteins *Endonucleases DNA Repair.
Ercc1 protein, Arabidopsis  EC 3.1.-   *DNA-Binding Proteins *Endonucleases *Arabidopsis Proteins DNA Repair.
rad1 protein, S pombe  EC 3.1.-   *DNA-Binding Proteins *Endonucleases *Schizosaccharomyces pombe Proteins DNA Repair.
Mus81 protein, mouse  EC 3.1.-   *DNA-Binding Proteins *Endonucleases DNA Damage.
MUS81 protein, human  EC 3.1.-   *DNA-Binding Proteins *Endonucleases DNA Damage.
ORF2 protein, Drosophila  0   *RNA-Directed DNA Polymerase *Drosophila Proteins Endonucleases. Nucleic Acids Res 2005;33(2):776-85
MUS81 protein, S pombe  0   *DNA-Binding Proteins *Endonucleases *Schizosaccharomyces pombe Proteins. Nucleic Acids Res 2004;32(18) (dup#2):5570-81
GEN protein, Drosophila  EC 3.1.-   *Endonucleases *Drosophila Proteins Exonucleases. Nucleic Acids Res 2004;32(21):6251-9
L1 ORF2 protein, human  0   *Endonucleases *RNA-Directed DNA Polymerase. Hum Mol Genet 2004 May 15;13(10):1041-8
YhcR protein, Bacillus subtilis  EC 3.1.31.-   *Bacterial Proteins *Endonucleases. J Bacteriol 2004 Aug;186(16):5376-83
endonuclease L1, human  EC 3.1.-   *Endonucleases. Structure (Camb) 2004 Jun;12(6):975-86
Apex2 protein, mouse  EC 3.1.-   *Endonucleases. Genomics 2003 Jan;81(1):47-57
Endou protein, mouse  0   *Endonucleases. Comp Biochem Physiol B Biochem Mol Biol. 2002 Nov;133(3):325-9
endonuclease I-PogI  EC 3.1.-   *Endonucleases. FEBS Lett. 2003 Jun 5;544(1-3):165-70
Dclre1c protein, mouse  EC 3.1.-.-   *Endonucleases *Nuclear Proteins DNA Repair. J Exp Med 2003 Mar 3;197(5):553-65
endonuclease I-SpomI, S pombe  EC 3.1.-   *Endonucleases *Schizosaccharomyces pombe Proteins. J Mol Evol 2002 Sep;55(3):302-13
UVDE protein, Neurospora crassa  EC 3.1.-   *Endonucleases. Mutat Res 2001 Dec 19;487(3-4):149-56
Eme1protein, S pombe  EC 3.1.-   *Endonucleases *Schizosaccharomyces pombe Proteins. Cell 2001 Nov 16;107(4):537-48
Bh1 protein, Basidiobolus haptosporus  EC 3.1.-   *Endonucleases *Exonucleases *Fungal Proteins. Eur J Biochem 2000 Aug;267(16):5123-35
MUS81 protein, S cerevisiae  EC 3.1.-   *DNA-Binding Proteins *Endonucleases *Saccharomyces cerevisiae Proteins DNA Damage. Mol Gen Genet 2000 Jun;263(5):812-27
CEL I nuclease  EC 3.1.30.-   *Endonucleases Plant Proteins Base Pair Mismatch. Biochemistry 2000 Apr 4;39(13):3533-41
endonuclease P40  EC 3.1.-   *Endonucleases. J Bacteriol 1997 Apr;179(7):2210-20
structure-specific endonuclease I  EC 3.1.21.-   *Endonucleases. Proc Natl Acad Sci USA 1999 Jul 20;96(15):8455-60
nuclease I, Syncephalastrum racemosum  EC 3.1.30.-   *Endonucleases. Biochem J 1999 Apr 15;339( Pt 2):261-7
endonuclease M  EC 3.1.30.-   *Endonucleases. J Biochem (Tokyo) 1998 Dec 1;124(6):1198-205
I-NjaI homing endonuclease  EC 3.1.-   *Endonucleases. Eur J Biochem 1999 Jan;259(1-2):281-8
SAE2 protein, S cerevisiae  0   *Endonucleases *Saccharomyces cerevisiae Proteins. Genetics 1997 Jul;146(3):797-816
nes protein, Staphylococcus aureus  EC 3.1.30.-   *Bacterial Proteins *Endonucleases. J Bacteriol 1996 Aug;178(16):4975-83
Mus-18 protein, Neurospora crassa  EC 3.1.-   *Endonucleases *Fungal Proteins DNA Repair. EMBO J 1995 May 15;14(10):2393-9
sugar-nonspecific nuclease  EC 3.1.-   *Endonucleases Endodeoxyribonucleases Endoribonucleases. J Bacteriol 1994 Feb;176(4):1093-8
DNA excision repair protein ERCC-5  0   *DNA-Binding Proteins *Endonucleases *Nuclear Proteins *Transcription Factors DNA Repair Drosophila Proteins Xenopus Proteins. Nature 1993 May 13;363(6425):114-5
ERCC1 protein, human  EC 3.1.-   *DNA-Binding Proteins *Endonucleases DNA Repair. Nucleic Acids Res 1991;19(20):5633
nuclease SP  EC 3.1.30.-   *Endonucleases Plant Proteins. Biochemistry 1991;30(40):9749
RAD1 protein, S cerevisiae  EC 3.1.-   *Endonucleases *Saccharomyces cerevisiae Proteins *DNA Repair Enzymes DNA Repair. FEBS Lett 1991;283(2):203
rep proteins, Adeno-associated virus 2  137750-19-7   *DNA-Binding Proteins *Viral Proteins Dependovirus Adenosine Triphosphatases DNA Helicases Endonucleases. Nature 1991;351(6321):78
single-strand-specific nuclease, endoplasmic reticulum  EC 3.1.30.-   *Endonucleases. Int J Biochem 1987;19(9):857
DNA single-stranded nuclease (pea seed)  EC 3.1.30.-   *Endonucleases. Arch Biochem Biophys 1987;255(2):437
single strand-specific endonuclease, mitochondria  EC 3.1.30.-   *Endonucleases. Nucleic Acids Res 1986;14(24):9579
streptococcal nuclease  EC 3.1.30.-   *Endonucleases. Z Naturforsch (C);38(1-2):107
endonuclease, Physarum polycephalum  EC 3.1.30.-   *Endonucleases. J Biochem (Tokyo) 1982;92(5):1655
primer activating enzymes  EC 3.1.4.-   *Deoxyribonucleases Endonucleases Exonucleases. Biochim Biophys Acta 1981;655(1):49
endonuclease A236  EC 3.1.21.-   *Endonucleases. Biokhimiia 1980;45(9):1597
TraI protein, E coli  EC 3.6.1.-   *DNA Helicases *Escherichia coli Proteins Endonucleases. J Biol Chem 1980;255(20):9746
DNA-specific endonuclease (xeroderma pigmentosum)  EC 3.1.4.-   *Endonucleases. Proc Natl Acad Sci USA 63:428;1969
termini-generating enzymes  EC 3.1.4.-   *Endonucleases. Proc Natl Acad Sci USA 70(9):2667;1973
poly A endonuclease  EC 3.1.4.-   *Endonucleases. J Biol Chem 254(22):11228;1979
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