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Endoribonucleases

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Definition: A family of enzymes that catalyze the endonucleolytic cleavage of RNA. It includes EC 3.1.26.-, EC 3.1.27.-, EC 3.1.30.-, and EC 3.1.31.-.     
Examples Micrococcal Nuclease; Ribonuclease H; Ribonuclease, Pancreatic; Ribonuclease T1; RNA-Induced Silencing Complex; Single-Strand Specific DNA and RNA Endonucleases
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
IntS9 protein, human  EC 3.1.-   *Endoribonucleases. Mol Cell Biol. 2012 Mar;32(6):1112-23.
dicer protein, S pombe  EC 3.1.-   *Endoribonucleases *Schizosaccharomyces pombe Proteins. Science. 2004 Jan 30;303(5658):672-6.
TSEN54 protein, zebrafish  EC 3.1.27.-   *Endoribonucleases *Zebrafish Proteins. Hum Mol Genet 2011 Apr 15;20(8):1574-84
TSEN54 protein, human  EC 3.1.27.-   *Endoribonucleases. Hum Mol Genet 2011 Apr 15;20(8):1574-84
JhI-1 protein, Drosophila  EC 3.1.-   *Endoribonucleases *Drosophila Proteins. Insect Biochem Mol Biol 2011 Mar;41(3):167-77
Dcp2 protein, mouse  EC 3.1.-   *Endoribonucleases. Mol Cell 2010 Nov 12;40(3):423-32
Csy4 endoribonuclease, Pseudomonas aeruginosa  EC 3.1.-   *Bacterial Proteins *Endoribonucleases. Science. 2010 Sep 10;329(5997):1355-8
PMR-1 polysomal ribonuclease 1, Xenopus laevis  EC 3.1.-   *Endoribonucleases *Xenopus Proteins. Biochemistry 1991 Oct 29;30(43):10490-8
tRNase Z protein, E coli  EC 3.1.-   *Endoribonucleases *Escherichia coli Proteins. Genes Cells 2008 Nov;13(11):1087-97
SMG6 protein, Drosophila  EC 3.1.-   *Endoribonucleases *Drosophila Proteins. RNA 2008 Dec;14(12):2609-17
tRNase Z, human  EC 3.1.-   *Endoribonucleases. RNA Biol 2008 Apr-Jun;5(2):104-11
RNase E, Arabidopsis  EC 3.1.-   *Endoribonucleases *Arabidopsis Proteins. RNA 2008 Jun;14(6):1057-68
ERN1 protein, human  EC 2.7.11.1   *Endoribonucleases *Protein-Serine-Threonine Kinases. Science 2000 Jan 28;287(5453):664-6
TRZ1 protein, Arabidopsis  EC 3.1.26.11   *Endoribonucleases *Arabidopsis Proteins. Biochemistry 2007 Dec 25;46(51):14742-50
RNase kappa, human  EC 3.1.-   *Endoribonucleases. Nucleic Acids Res 2007;35(19):6389-98
squash protein, Drosophila  EC 3.1.-   *Endoribonucleases *Drosophila Proteins. Dev Cell 2007 Jun;12(6):851-62
zucchini protein, Drosophila  EC 3.1.-   *Endoribonucleases *Drosophila Proteins. Dev Cell 2007 Jun;12(6):851-62
Dcp2 protein, Arabidopsis  EC 3.1.27.-   *Endoribonucleases *Arabidopsis Proteins. Plant Cell 2006 Dec;18(12):3386-98
Dcp1 protein, Arabidopsis  EC 3.1.27.-   *Endoribonucleases *Arabidopsis Proteins. Plant Cell 2006 Dec;18(12):3386-98
Swt1 protein, S cerevisiae  EC 3.1.-   *Endoribonucleases *Transcription Factors *Saccharomyces cerevisiae Proteins. J Biol Chem 2006 Dec 1;281(48):36518-25
colicin E5 protein, E coli  EC 3.1.-   *Endoribonucleases *Escherichia coli Proteins. Nucleic Acids Res 2006;34(21):6065-73
tRNase Z, S cerevisiae  EC 3.1.-   *Endoribonucleases *Saccharomyces cerevisiae Proteins. BMC Mol Biol 2005;6(1):12
inositol requiring enzyme-1, Drosophila  EC 3.1.-   *Endoribonucleases *Drosophila Proteins Membrane Proteins. Science 2006 Jul 7;313(5783):104-7
Ern1 protein, mouse  EC 2.7.11.1   *Endoribonucleases *Protein-Serine-Threonine Kinases. Brain Res Mol Brain Res 2000 Dec 28;85(1-2):68-76
Dcp2 protein, C elegans  EC 3.1.-   *Endoribonucleases. Mol Cell Biol 2005 Oct 25;(20):8779-91
DCAP-1 protein, C elegans  EC 3.1.27.-   *Endoribonucleases *Caenorhabditis elegans Proteins. Mol Biol Cell 2006 Jan;17(1):336-44
DcpS protein, mouse  EC 3.1.27.-   *Endoribonucleases. Proteins 2005 Sep 1;60(4):797-802
Sen34 protein, S cerevisiae  EC 3.1.-   *Endoribonucleases *Saccharomyces cerevisiae Proteins RNA Splicing. Biochem Biophys Res Commun 2005 Nov 11;337(1):89-94
argonaute protein, Aquiflex aeolicus  EC 3.1.26.-   *Endoribonucleases. Mol Cell 2005 Aug 5;19(3):405-19
ChpBK protein, E coli  EC 3.1.27.-   *Endoribonucleases *Escherichia coli Proteins. J Biol Chem 2005 Jul 15;280(28):26080-8
tRNase Z, Drosophila  EC 3.1.-   *Endoribonucleases *Drosophila Proteins. J Mol Biol 2005 Jul 8;350(2):189-99
hcs protein, S pombe  EC 3.1.26.-   *Endoribonucleases *Schizosaccharomyces pombe Proteins.
PAC1 protein, S cerevisiae  EC 3.1.26.-   *Endoribonucleases *Saccharomyces cerevisiae Proteins.
RNase 6, mouse  EC 3.1.-   *Endoribonucleases. J Mol Evol 2004 Nov;59(5):657-65
Ear5 protein, mouse  EC 3.1.-   *Endoribonucleases. Nucleic Acids Res 1997 Nov 1;25(21):4235-9
Rnase4 protein, mouse  EC 3.1.-   *Endoribonucleases. Nucleic Acids Res 2005;33(3):1077-86
DCP1b protein, human  EC 3.1.27.-   *Endoribonucleases. J Cell Biol 2004 Apr12;165(1):31-40
DcpS protein, human  EC 3.1.27.-   *Endoribonucleases. Mol Cell. 2004 Apr 9;14(1):67-80
XendoU protein, Xenopus  EC 3.1.26.-   *Endoribonucleases *Xenopus Proteins. J Biol Chem 2003 Apr 11;278(15):13026-32
Clipper protein, Drosophila  EC 3.1.-   *Endoribonucleases *Drosophila Proteins Zinc Fingers. IUBMB Life 2002 Jul;54(1):27-31
DCP2 protein, human  EC 3.1.27.-   *Endoribonucleases. Proc Natl Acad Sci U S A 2002 Oct 1;99(20):12663-8
DCP1A protein, human  EC 3.1.27.-   *Endoribonucleases *Trans-Activators. Nat Cell Biol 2002 Mar;4(3):181-90
ZFY-6 zinc finger ribonuclease  EC 3.1.-   *Endoribonucleases *Transcription Factors Zinc Fingers. Methods Enzymol 2001;341:490-500
erythroid-enriched endoribonuclease protein, mouse  EC 3.1.-   *Endoribonucleases. J Biol Chem 2002 Jan 25;277(4):2385-952597-604
varkud satellite ribozyme  EC 3.1.27.-   *Endoribonucleases *RNA, Catalytic. EMBO J 2001 Oct 1;20(19):5461-9
RC-RNase 2  EC 3.1.-   *Endoribonucleases. J Biomol NMR 2001 Jan;19(1):87-8
MazF protein, E coli  0   *DNA-Binding Proteins *Endoribonucleases *Escherichia coli Proteins Apoptosis. Proc Natl Acad Sci U S A 1996 Jun 11;93(12):6059-63
SAPC protein, human  EC 3.1.26.-   *Endoribonucleases *Neoplasm Proteins. Am J Pathol 2001 Jan;158(1):19-24
lactoribonuclease  EC 3.1.27.-   *Endoribonucleases. Life Sci 2000 Sep 8;67(16):2025-32
Bi2 maturase  EC 3.1.21.-   *Endoribonucleases RNA Splicing. Mol Gen Genet 2000 Sep;264(1-2):137-44
T4 RegB endoribonuclease  EC 3.1.27.-   *Endoribonucleases Viral Proteins. J Mol Biol 2000 Apr 14;297(5):1063-74
ERN2 protein, human  EC 2.7.1.-   *Endoribonucleases *Membrane Proteins *Protein-Serine-Threonine Kinases. Science 2000 Jan 28;27(5453):664-6
ribosomal RNA apurinic site specific lyase  EC 3.1.26.-   *Endoribonucleases. EMBO J 1999 Nov 15;18(22):6522-31
DCP2 protein, S cerevisiae  EC 3.1.-   *Endoribonucleases *Saccharomyces cerevisiae Proteins. EMBO J 1999 Oct 1;18(19):5411-22
polysomal RNase 1  EC 3.1.-   *Endoribonucleases. RNA 1998 Dec;4(12):1537-48
G3BP protein, human  0   *Carrier Proteins Endoribonucleases Repressor Proteins.
MAR1 protein, Leishmania tarentolae  EC 3.1.-   *Endoribonucleases *Protozoan Proteins. J Biol Chem 1998 Nov 6;273(45):30003-11
ribonuclease T84  EC 3.1.26.-   *Endoribonucleases. Nucleic Acids Res 1998 Sep 1;26(17):4047-55
wound-inducible ribonuclease, Nicotiana  EC 3.1.27.-   *Endoribonucleases. Biosci Biotechnol Biochem 1998 Jun;62(6):1144-51
Dom34 protein, S cerevisiae  EC 3.1.-   *Endoribonucleases *Cell Cycle Proteins *Saccharomyces cerevisiae Proteins. Genetics 1998 May;149(1):45-56
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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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