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Endorphins

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Definition: One of the three major groups of endogenous opioid peptides. They are large peptides derived from the PRO-OPIOMELANOCORTIN precursor. The known members of this group are alpha-, beta-, and gamma-endorphin. The term endorphin is also sometimes used to refer to all opioid peptides, but the narrower sense is used here; OPIOID PEPTIDES is used for the broader group.     
Pharmacological Action Neurotransmitter Agents
See Also Receptors, Opioid
Examples alpha-Endorphin; beta-Endorphin; gamma-Endorphin 		Other names Endorphin
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
morphiceptin, Dmt(1)-NMeAla(2)-1-Nal(3)  0   *Endorphins Ligands Receptors, Opioid, mu. Peptides 2010 Aug;31(8):1617-24
morphiceptin, Dmt(1)-Ala(2)-1-Nal(3)  0   *Endorphins Ligands Receptors, Opioid, mu. Peptides 2010 Aug;31(8):1617-24
morphiceptin, Dmt(1)-Nal(3)  0   *Endorphins. Peptides 2008 Apr;29(4):633-8
Tyr-cav, rat  0   *Endorphins. Methods Find Exp Clin Pharmacol. 2004 Jun;26(5):335-8
endorphin (20-31)  0   *beta-Endorphin *Peptide Fragments Endorphins. Regul Pept 1998 Jan 2;73(1):67-72
endorphin (1-20)  0   *beta-Endorphin *Peptide Fragments Endorphins. Regul Pept 1998 Jan 2;73(1):67-72
neokyotorphin (1-4)  0   *Endorphins *Peptide Fragments. Biochem Biophys Res Commun 1996 Jul 25;324(3):721-7
beta-casomorphin-4-nitroanilide  0   *Endorphins. Acta Physiol Hung 1994;82(2):131-8
tyrosyl-cyclo(ornithyl-(2-naphthyl)alanyl-prolyl-glycyl-)  155919-39-4   *Peptides, Cyclic Endorphins. J Med Chem 1994 Apr 15;37(8):1136-44
tyrosyl-cyclo(ornithyl-phenylalanyl-prolyl-glycyl-)  136037-37-1   *Peptides, Cyclic Endorphins. J Med Chem 1994 Apr 15;37(8):1136-44
CM 2-3  138474-03-0   *Endorphins. Proc West Pharmacol Soc 1991;34:429-32
morphiceptin, Val(4)  0   *Endorphins. Int J Pept Protein Res 1991;37(5):364
casomorphin, Trp(3)  134406-64-7   *Endorphins *Peptide Fragments Caseins. Int J Pept Protein Res 1991;37(4):257
delta-endorphin  69599-55-9   *Endorphins. Bioorg Khim 1990;16(5):649
cytochrophin-4  97730-74-0   *Endorphins. Eur J Pharmacol 1989;166(3):523
beta-casomorphin, des-Tyr  82289-41-6   *Endorphins *Peptide Fragments. Biomed Biochim Acta 1988;47(9):865
beta casomorphin 8 protein, human  95210-75-6   *Endorphins *Peptide Fragments Caseins. Regul Pept 1988;20(2):107
historphin  105250-85-9 Glycine, N-(N-(N-(N-L-tyrosylglycyl)-L-phenylalanyl)glycyl)  *Endorphins. Dokl Akad Nauk SSSR 1986;289(4):1009
lysyl-lysyl-glycyl-glutamic acid  72189-84-5   *Endorphins *Peptide Fragments Oligopeptides. Neuropeptides 1986;8(1):45
hemorphin 5  103930-65-0   *Hemoglobins *Peptide Fragments Endorphins. Eur J Pharmacol 1986;125(2):309
hemorphin 4  103930-64-9 L-Threonine, N-(N-(1-L-tyrosyl-L-prolyl)-L-tryptophyl)  *Hemoglobins *Peptide Fragments Endorphins. Eur J Pharmacol 1986;125(2):309
bis(tyrosyl-prolyl-phenylalaninamide)hydrazide  88191-66-6   *Oligopeptides Endorphins. Acta Physiol Pol 1984;35(4):310
bis(tyrosyl-alanyl-phenylalaninamide)hydrazide  88191-63-3   *Oligopeptides Endorphins. Acta Physiol Pol 1984;35(4):310
amidorphin (8-26)  102203-22-5   *Endorphins *Peptide Fragments. Proc Natl Acad USA 1986;83(6):1936
beta-casomorphin 11  101554-61-4   *Endorphins *Peptide Fragments Caseins. FEBS Lett 1986;196(2):223
beta casomorphin 4027  98815-38-4   *Endorphins. Regul Pept Suppl 1985;4:219
amidorphin  94885-44-6   *Endorphins. J Neurochem 1985;45(5):1495
beta-casomorphin I  97453-39-9   *Endorphins *Peptide Fragments Caseins. Exp Clin Endocrinol 1985;85(2):249
morphiceptin, N-Me-Phe(3)  83397-56-2   *Endorphins Receptors, Opioid. Brain Res 1984;323(1):73
gamma-endorphin generating enzyme  EC 3.4.99.-   *Endopeptidases Endorphins. Anal Biochem 1984;141(1):1
beta-casomorphin 4  74171-19-0   *Endorphins *Peptide Fragments Caseins. Peptides (Fayetteville) 1984;5(4):829
beta-casomorphin 7  72122-62-4   *Endorphins *Peptide Fragments Caseins. FEBS Lett 1984;169(1):53
N-acetyl-gamma-endorphin  86741-97-1 alpha-Endorphin, N-acetyl-16a-L-leucine  *Endorphins. Life Sci 1984;34(14):1317
N-acetyl-alpha-endorphin  88264-63-5 alpha-Endorphin, N-acetyl  *Endorphins. Life Sci 1983;33 suppl 1:9
morphiceptin, N-Me-Phe(3)-Pro(4)  0   *Endorphins. Pharmacol Biochem Behav 1983;19(2):379
neo-kyotorphin  83759-54-0 L-Arginine, N2-(N-(N2-(N-L-threonyl-L-seryl)-L-lysyl)-L-tyrosyl)  *Endorphins Stereoisomerism.
Pharma Action Analgesics ; Anticonvulsants 		Life Sci 1982;31(16-17):1733
deacetyl salmon endorphin  74893-30-4   *Endorphins. Life Sci 1982;31(16-17):1707
rimorphin  83335-41-5 Dynorphin B  *Dynorphins *Endorphins. Proc Natl Acad Sci USA 1982;79(21):6480
beta-casomorphin 5  72122-63-5   *Endorphins *Peptide Fragments Caseins.
Pharma Action Analgesics 		Pharmazie 1982;37(3):165
circulating opioid factor  0   *Endorphins. Neuroscience 1981;6(10):1935
adrenal opioid peptide E  0   *Endorphins. Proc Natl Acad Sci USA 1981;78(5):3265
endorphin, humoral  77030-45-6 Endorphin, humoral  *Endorphins. Life Sci 1980;27(23):2167
morphiceptin  74135-04-9   *Endorphins.
Pharma Action Analgesics ; Convulsants 		Science 1981;212(4490):75
alpha-neoendorphin  69671-17-6   *Endorphins *Protein Precursors. Adv Biochem Psychopharmacol 1980;22:591
alpha-endorphin, des-Tyr(1)  69460-01-1 alpha-Endorphin, 1-de-L-tyrosine  *Endorphins. Life Sci 1980;26(11):851
beta-casomorphins  79805-24-6   *Endorphins Caseins Receptors, Opioid, mu/agonists Receptors, Opioid, delta/antagonists & inhibitors.
Pharma Action Analgesics, Opioid 		Hoppe Seylers Z Physiol Chem 360(9):1211;1979; Hoppe Seylers Z Physiol Chem 360(9):1217;1979
kyotorphin  70904-56-2 L-Arginine, N2-L-tyrosyl  *Endorphins.
Pharma Action Analgesics 		Eur J Pharmacol 55(1):109;1979
gamma-endorphin, des-Tyr(1)  67810-56-4   *Endorphins *Peptide Fragments Avoidance Learning/drug effects Schizophrenia/drug therapy.
Pharma Action Antidepressive Agents 		Arch Gen Psychiatry 36(3):294;1979; Eur J Pharmacol 1979;60(4):359

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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