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Enkephalin, Leucine

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Definition: One of the endogenous pentapeptides with morphine-like activity. It differs from MET-ENKEPHALIN in the LEUCINE at position 5. Its first four amino acid sequence is identical to the tetrapeptide sequence at the N-terminal of BETA-ENDORPHIN.  DF: LEU ENKEPHALIN   
Pharmacological Action Neurotransmitter Agents 		Other names Leucine Enkephalin; Leu Enkephalin; Enkephalin, 5-Leucine; 5 Leucine Enkephalin; Leu-Enkephalin; Leu(5)-Enkephalin; 5-Leucine Enkephalin
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
leucine enkephalin, N,N-dibenzyl(Phe(p-NCS))(4)  0   Enkephalin, Leucine/*analogs & derivatives. J Med Chem 2000 Oct 19;43(21):3941-8
tyrosyl-threonyl-glycyl--phenylalanyl-leucyl-O-glucosylserinamide  0   Enkephalin, Leucine/*analogs & derivatives. J Med Chem 2000 Jun 29;43(13):2586-90
tyrosyl-glycyl-sarcosyl-(4-nitro)phenylalanyl-leucinamide  0   Enkephalin, Leucine/*analogs & derivatives. J Inorganic Biochem 1995 Oct;60(1):21-9
tyrosyl-glycyl-glycyl-(4-nitro)phenylalanyl-leucinamide  0   Enkephalin, Leucine/*analogs & derivatives. J Inorg Biochem 1995 Oct;60(1):21-9
enkephalinamide-Leu, cyclo(alpha,gamma-dibutyric acid(2)-glutamyl(3))  157878-99-4   Enkephalin, Leucine/*analogs & derivatives. Int J Pept Rotein Res 1994 Mar;43(3):292-6
Leu-enkephalin-tyrosyl-arginyl-glycyl-phenylalanine ethyl ester  0   Enkephalin, Leucine/*analogs & derivatives. Zh Vyssh Nerv Deiat 1992 Mar-Apr;42(2):378-80
enkephalinamide, Gly(2)-psi-(methyleneoxy)-Gly(3)-Leu(5)  98900-28-8   Enkephalin, Leucine/*analogs & derivatives. J Med Chem 1991;34(8):2430
enkephalinamide, Tyr(1)-psi-(methyleneoxy)-Gly(2)-Leu(5)  133851-90-8   Enkephalin, Leucine/*analogs & derivatives. J Med Chem 1991;34(8):2430
enkephalin, Arg(2)-Leu(5)  76939-27-0   Enkephalin, Leucine/*analogs & derivatives. Ukr Biokhim ZH 1990;62(4):15
enkephalin-Leu, Gly-Pro-(Lys-Aib-Leu-Aib)(2)-OMe  117397-68-9   Enkephalin, Leucine/*analogs & derivatives. Int J Pept Protein Res 1990;35(6):545
enkephalin-Leu, Gly-Pro-(Lys-Pro-Pro-Pro)2-OMe  117397-69-0   Enkephalin, Leucine/*analogs & derivatives. Int J Pept Protein Res 1990;35(6):545
enkephalin-Leu, Gly-Pro-(Lys-Sar-Sar-Sar)(2)-OMe  117397-70-3   Enkephalin, Leucine/*analogs & derivatives. Int J Pept Protein Res 1990;35(6):545
t-butyloxycarbonyltyrosyl-glycyl-glycyl-phenylalanyl-psi(thioamide)leucyl benzyl ester  125482-08-8   *Thioamides Enkephalin, Leucine/*analogs & derivatives. Int J Pept Protein Res 1989;34(5):369
enkephalin, H-Tyr-cyclo-(N(delta)-Orn-Gly-Phe-Leu)  83159-95-9   *Peptides, Cyclic Enkephalin, Leucine/*analogs & derivatives. J Med Chem 1986;29(9):1658
enkephalin-Leu, dehydro-Phe(4)  91549-05-2   Enkephalin, Leucine/*analogs & derivatives. Int J Pept Protein Res 1986;27(5):522
tyrosyl-cyclo(lysyl-glycyl-phenylalanyl-psi(thiomethylene)leucine)  103881-76-1   *Peptides, Cyclic Enkephalin, Leucine/*analogs & derivatives. Biochem Biophys Res Commun 1986;136(2):730
enkephalinamide-Leu  60117-24-0   Enkephalin, Leucine/*analogs & derivatives. Peptides (Fayetteville) 1985;6(6):1253
cyclo(lysyl-tyrosyl-glycyl-glycyl-phenylalanyl-leucyl)  99764-53-1   *Peptides, Cyclic Enkephalin, Leucine/*analogs & derivatives. Bioorg Khim 1985;11(11):1457
enkephalin, N-cyclo-Leu(5)  75975-40-5   Enkephalin, Leucine/*analogs & derivatives. Arch Biochem Biophys 1985;238(1):111
enkephalinamide-Leu, Tyr sulfate(1)  0   Enkephalin, Leucine/*analogs & derivatives. Life Sci 1984;35(8):815
enkephalin-Leu, des-Tyr(1)  60254-83-3   Enkephalin, Leucine/*analogs & derivatives. Arch Biochem Biophys 1984;233(1):115
enkephalin-Leu, 4'-bromo-Phe(4)  89705-56-6 L-Leucine, N-(4-bromo-N-(N-(N-L-tyrosylglycyl)glycyl)-L-phenylalanyl)  Enkephalin, Leucine/*analogs & derivatives. Biochem J 1984;218(3):677
phorphin  88847-78-3   Enkephalin, Leucine/*analogs & derivatives. Biokhimiia 1983;48(12):1939
N,N-diallyl-tyrosyl-alpha-aminoisobutyric acid-phenylalanyl-leucine  89352-67-0 L-Leucine, N-(N-(N-(N,N-di-2-propenyl-L-tyrosyl)-2-methylalanyl)-L-phenylalanyl)  Enkephalin, Leucine/*analogs & derivatives.
Pharma Action Narcotic Antagonists 		Eur J Pharmacol 1984;97(3-4):331
enkephalin-Leu, 4-hydroxycinnamoyl(1)  88492-42-6 L-Leucine, N-(N-(N-(N-(3-(4-hydroxyphenyl)-1-oxo-2-propenyl)glycyl)glycyl)-L-phenylalanyl)-, (E)  Enkephalin, Leucine/*analogs & derivatives. Int J Pept Protein Res 1983;22(4):434
enkephalin-azo-albumin  0   *Serum Albumin, Bovine Enkephalin, Leucine/*analogs & derivatives. Arch Immunol Ther Exp (Warsz) 1982;30(5-6):405
ICI 154129  83420-94-4 Glycinamide, N,N-di-2-propenyl-L-tyrosyl-N-(2-((2-((1-carboxy-3-methylbutyl)amino)-2-oxo-1-(phenylmethyl)ethyl)thio)ethyl)-, (S-(R*,R*))  Enkephalin, Leucine/*analogs & derivatives.
Pharma Action Narcotic Antagonists 		Life Sci 1982;31(12-13):1259
enkephalin, Ser(2), Leu(5), Thr(6)  75644-90-5   Enkephalin, Leucine/*analogs & derivatives.
Pharma Action Analgesics ; Convulsants 		Eur J Pharmacol 1982;78(3):385
enkephalin-Leu, Arg(6)-PheNH2(7)  80690-78-4 alpha-Neoendorphin, 7-L-phenylalaninamide-8-de-L-tyrosine-9-de-L-proline-10-de-L-lysine  Enkephalin, Leucine/*analogs & derivatives. Neurosci Lett 1981;27(1):25
enkephalin-Leu, Arg(6)-Phe(7)  79358-92-2 alpha-Neoendorphin, 7-L-phenylalanine-8-de-L-tyrosine-9-de-L-proline-10-de-L-lysine  Enkephalin, Leucine/*analogs & derivatives. Neurosci Lett 1981;27(1):25
enkephalin-Leu, sulfonated  80632-52-6 L-Leucine, N-(N-(N-(N-(O-sulfo-L-tyrosyl)glycyl)glycyl)-L-phenylalanyl)  Enkephalin, Leucine/*analogs & derivatives. Nature 1982;295(5849):519; Neuropharmacology 1981;20(10):963
cyclic leucine enkephalin  79525-56-7 Cyclic(glycylglycyl-L-phenylalanyl-L-leucyl-L-lysyl-L-lysyl-L-tyrosyl)  Enkephalin, Leucine/*analogs & derivatives. Hoppe Seylers Z Physiol Chem 1981;362(6):593
enkephalin-Leu, 4-(hydroxyphenyl)azo  76995-91-0 L-Leucine, N-(4-((hydroxyphenyl)azo)-N-(N-(N-L-tyrosylglycyl)glycyl)-L-phenylalanyl)  Enkephalin, Leucine/*analogs & derivatives. Mol Cell Biochem 1981;34(1):23
enkephalin-Leu, NH2(3)  71027-11-7   Enkephalin, Leucine/*analogs & derivatives. Mol Cell Biochem 1981;34(1):23
enkephalin-Leu, Arg(6,7)  77101-32-7 L-Arginine, N2-(N2-(N-(N-(N-(N-L-tyrosylglycyl)glycyl)-L-phenylalanyl)-L-leucyl)-L-arginyl)  Enkephalin, Leucine/*analogs & derivatives. Biochem Biophys Res Commun 1981;98(3):752
enkephalin-Leu, cyclo-N(gamma)-diNH-butyryl  77171-72-3 L-Leucine, L-tyrosyl-D-alpha,gamma-diaminobutyrylglycyl-L-phenylalanyl-, cyclic (5-2)-peptide  Enkephalin, Leucine/*analogs & derivatives. Proc Natl Acad Sci USA 1980;77(12):7162
pro-enkephalin-Leu  0   *Enkephalin, Leucine *Protein Precursors. Biochem Biophys Res Commun 1980;95(4):1467
enkephalin-Leu, Arg(6)  75106-70-6 alpha-Neoendorphin, 7-de-L-lysine-8-de-L-tyrosine-9-de-L-proline-10-de-L-lysine  Enkephalin, Leucine/*analogs & derivatives. Biochem Biophys Res Commun 1980;95(4):1467
enkephalin-Leu, acetaldehyde  76157-62-5 L-Leucine, N-(N-(N-((4-((4-hydroxyphenyl)methyl)-2-methyl-5-oxo-1-imidazolidinyl)acetyl)glycyl)-L-phenylalanyl)  Enkephalin, Leucine/*analogs & derivatives. FEBS Lett 1980;111(2):307

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