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Enkephalin, Methionine

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Definition: One of the endogenous pentapeptides with morphine-like activity. It differs from LEU-ENKEPHALIN by the amino acid METHIONINE in position 5. Its first four amino acid sequence is identical to the tetrapeptide sequence at the N-terminal of BETA-ENDORPHIN.  DF: ENKEPHALIN MET or MET ENKEPHALIN   
Pharmacological Action Neurotransmitter Agents 		Other names Methionine Enkephalin; Met Enkephalin; Enkephalin, 5-Methionine; 5 Methionine Enkephalin; Met-Enkephalin; Met(5)-Enkephalin; 5-Methionine Enkephalin
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
Enkorten  0   *alpha-MSH *Enkephalin, Methionine Drug Combinations. Med Arh 2008;62(1):41-4
Met-enkephalin-glycyl-tyrosine  0   Enkephalin, Methionine/*analogs & derivatives. J Pharmacol Exp Ther 2005 Aug;314(2):862-7
Ala2-YAGFMKKKFMRFamide  0   *Enkephalin, Methionine *FMRFamide. Brain Res Bull 2001 May 1;55(1)51-7
Met-enkephalin-FMRFa chimeric peptide  0   *Enkephalin, Methionine *FMRFamide. Peptides 1999;20(4):471-8
enkephalinamide, Met(2)-Pro(5)-(N(1,5)-2,3,4,6-O-tetraacetylglycosyl)  0   Enkephalin, Methionine/*analogs & derivatives. Drug Des Discov 1997 Aug;15(2):83-94
enkephalin, delta-Ala(2)-Met(5)  0   Enkephalin, Methionine/*analogs & derivatives. Cell Mol Neurobiol 1992 Oct;12(5):463-72
enkephalin-Met, Trp(4)  63074-20-4   Enkephalin, Methionine/*analogs & derivatives. Pharmazie 1988;43(2):116
BAM 18P  105284-56-8   *Protein Precursors Enkephalin, Methionine/*analogs & derivatives. Eur J Pharmacol 1987;138(3):359
nifalatide  73385-60-1 L-Prolinamide, L-tyrosyl-gamma-(methylsulfinyl)-D-alpha-aminobutyrylglycyl-4-nitro-L-phenylalanyl  Enkephalin, Methionine/*analogs & derivatives. Clin Pharmacol Ther 1986;39(1):40
enkephalin-Met, Ala(2)-4-azido-Phe(4)  98749-66-7   Enkephalin, Methionine/*analogs & derivatives. Int J Peptide Protein Res 1985;26(1):63
enkephalinamide-Met, Tyr sulfate(1)-Ala(2)  92175-45-6 L-Methioninamide, O-sulfo-L-tyrosyl-D-alanylglycyl-L-phenylalanyl-, (3aS-(3aalpha,4beta,6aalpha))  Enkephalin, Methionine/*analogs & derivatives. Life Sci 1984;35(8):815
enkephalin-Met, Lys(6)-Arg(7)  83404-42-6   Enkephalin, Methionine/*analogs & derivatives. FEBS Lett 1984;172(2):212
enkephalin-Met, 4'-bromo-Phe(4)  89705-57-7 L-Methionine, N-(4-bromo-N-(N-(N-L-tyrosylglycyl)glycyl)-L-phenylalanyl)  Enkephalin, Methionine/*analogs & derivatives. Biochem J 1984;218(3):677
adrenorphin  88377-68-8 Adrenorphin  Enkephalin, Methionine/*analogs & derivatives. Nature 1983;305(5936):721
enkephalin-Met, Arg(6)-Gly(7)-Leu(8)-Lys(9)  86533-29-1 alpha-Neoendorphin, 5-L-methionine-7-glycine-8-L-leucine-9-de-L-proline  Enkephalin, Methionine/*analogs & derivatives. Eur J Pharmacol 1983;90(1):147
enkephalinamide-Met sulfoxide, Ala(2)  70021-29-3 Butanamide, L-tyrosyl-D-alanylglycyl-L-phenylalanyl-gamma-(methylsulfinyl)-L-alpha-amino  Enkephalin, Methionine/*analogs & derivatives. Life Sci 1983;32(8):889
enkephalinamide, Met-metazocine  83380-08-9 L-Methioninamide, N-((3,4,5,6-tetrahydro-8-hydroxy-3,6,11-trimethyl-2,6-methano-3-benzazocin-2(1H)-yl)carbonyl)glycylglycyl-L-phenylalanyl-, (2R-(2alpha,6beta,11R*))  Enkephalin, Methionine/*analogs & derivatives. J Med Chem 1982;25(12):1423
peptide F  75718-92-2 Peptide F  *Protein Precursors Enkephalin, Methionine/*analogs & derivatives. Life Sci 1982;31(16-17):1883
metkephamid acetate  69924-15-8   Enkephalin, Methionine/*analogs & derivatives. Lancet 1982;1(8286):1374
enkephalin-Met, Tyr-O-sulfate  81788-49-0 L-Methionine, N-(N-(N-(N-(O-sulfo-L-tyrosyl)glycyl)glycyl)-L-phenylalanyl)  Enkephalin, Methionine/*analogs & derivatives. Life Sci 1982;30(18):1565
enkephalin-Met, 5-amino-Val(2)-des-Gly(3)  82518-82-9 L-Methionine, N-(N-(5-((2-amino-3-(4-hydroxyphenyl)-1-oxopropyl)amino)-1-oxopentyl)-L-phenylalanyl)-, (S)  Enkephalin, Methionine/*analogs & derivatives. Biochem Biophys Res Commun 1982;106(1):113
methionine-enkephalin receptor  0   *Receptors, Opioid Enkephalin, Methionine. J Biol Chem 1982;25(3):1274
enkephalin-Met, Arg(6)-PheNH2(7)  78761-61-2 L-Phenylalaninamide, L-tyrosylglycylglycyl-L-phenylalanyl-L-methionyl-L-arginyl  Enkephalin, Methionine/*analogs & derivatives. Neurosci Lett 1981;27(1):25
enkephalin-Met, Arg(6)-Gly(7)-Leu(8)  80501-44-6 L-Leucine, N-(N-(N2-(N-(N-(N-(N-L-tyrosylglycyl)glycyl)-L-phenylalanyl)-L-methionyl)-L-arginyl)glycyl)  Enkephalin, Methionine/*analogs & derivatives. Biochem Biophys Res Commun 1981;103(2):698
enkephalinamide-Met, Ala(2)-N-Me(5)  72719-77-8   Enkephalin, Methionine/*analogs & derivatives. Life Sci 1981;29(14):1429
enkephalin-Met, des-Tyr(1)  61370-88-5   Enkephalin, Methionine/*analogs & derivatives. Neurosci Lett 1981;22(2):189
enkephalin-Met, sulfoxide  60283-51-4   Enkephalin, Methionine/*analogs & derivatives. Life Sci 1981;28(7):781
enkephalinamide-Met, Ala(2,3)  75059-08-4   Enkephalin, Methionine/*analogs & derivatives. Br J Pharmacol 1980;71(1):201
BAM-20P  0   *Protein Precursors Enkephalin, Methionine/*analogs & derivatives. Biochem Biophys Res Commun 1980;97(4):1283
BAM 22P  76622-26-9 Glycine, L-tyrosylglycylglycyl-L-phenylalanyl-L-methionyl-L-arginyl-L-arginyl-L-valylglycyl-L-arginyl-L-prolyl-L-alpha-glutamyl-L-tryptophyl-L-tryptophyl-L-methionyl-L-alpha-aspartyl-L-tyrosyl-L-glutaminyl-L-lysyl-L-arginyl-L-tyrosyl  *Protein Precursors Enkephalin, Methionine/*analogs & derivatives. Biochem Biophys Res Commun 1980;97(4):1283
enkephalin-Met, Arg(6)  76310-14-0 L-Arginine, N2-(N-(N-(N-(N-L-tyrosylglycyl)glycyl)-L-phenylalanyl)-L-methionyl)  Enkephalin, Methionine/*analogs & derivatives. Arch Biochem Biophys 1980;205(2):606
enkephalin-Met, Lys(6)  75909-25-0 L-Lysine, N2-(N-(N-(N-(N-L-tyrosylglycyl)glycyl)-L-phenylalanyl)-L-methionyl)  Enkephalin, Methionine/*analogs & derivatives. Arch Biochem Biophys 1980;205(2):606
enkephalin-Met, Arg(6,7)  76496-10-1 L-Arginine, N2-(N2-(N-(N-(N-(N-L-tyrosylglycyl)glycyl)-L-phenylalanyl)-L-methionyl)-L-arginyl)  Enkephalin, Methionine/*analogs & derivatives. Arch Biochem Biophys 1980;205(2):606
metkephamid  66960-34-7   Enkephalin, Methionine/*analogs & derivatives. Science 1981;211(4482):603
enkephalin-Met, Arg(6)-Phe(7)  73024-95-0 L-phenylalanine, N-(N(2)-(N-(N-(N-(N-L-tyrosylglycyl)glycyl)-L-phenylalanyl)-l-methionyl)-L-arginyl)  Enkephalin, Methionine/*analogs & derivatives. Life Sci 1982;31(23):2555; Proc Natl Acad Sci USA 1980;77(9):5512
BAM 12P  75513-71-2 L-Glutamic acid, N-(1-(N(2)-(N-(N-(N(2)-(N(2)-(N-(N-(N-(N-L-tyrosylglycyl)glycyl)-L-phenylalanyl)-L-methionyl)-L-arginyl)-L-arginyl)-L-valyl)glycyl)-L-arginyl)-L-prolyl)  *Protein Precursors Enkephalin, Methionine/*analogs & derivatives. Biochem Biophys Res Commun 1980;95(4):1482
pro-Met-enkephalin  0   *Enkephalin, Methionine *Protein Precursors. Biochem Biophys Res Commun 1980;95(2):665
enkephalin-Met, like substances  0   Enkephalin, Methionine/*analogs & derivatives. No To Shinkei 1980;32(3):309
enkephalinamide-Met, Ala(2)-(penta-F-Phe)(4)  67875-58-5 L-Methioninamide, L-tyrosyl-D-alanylglycyl-2,3,4,5,6-pentafluoro-L-phenylalanyl  Enkephalin, Methionine/*analogs & derivatives. Pharmacol Biochem Behav 1979;11(6):705
enkephalin-Met, acetaldehyde  74080-62-9 L-Methionine, N-(N-(N-((4-((4-hydroxyphenyl)methyl)-2-methyl-5-oxo-1-imidazolidinyl)acetyl)glycyl)-L-phenylalanyl)  Enkephalin, Methionine/*analogs & derivatives. FEBS Lett 1980;111(2):307
enkephalinamide-Met, Ala(2)  61090-95-7   Enkephalin, Methionine/*analogs & derivatives. Brain Res 1980;186(2):486; Life Sci 25(19):1697;1979
enkephalin, Met(2)-ProNH2(5)  63307-63-1 L-tyrosyl-D-methionylglycyl-L-phenylalanyl-L- prolinamide  Enkephalin, Methionine/*analogs & derivatives.
Pharma Action Analgesics ; Anti-Arrhythmia Agents 		Neurochem Res 4(5):627;1979
Met-enkephalinamide  60117-17-1 L-Methioninamide, L-tyrosylglycylglycyl-L-phenylalanyl  Enkephalin, Methionine/*analogs & derivatives. Eur J Biochem 97(1):43;1979
enkephalinamide-Met, Ala(2)-didehydro-Phe(4)  69181-23-3 L-Methioninamide, L-tyrosyl-D-alanylglycyl-(Z)-alpha,beta-didehydrophenylalanyl  Enkephalin, Methionine/*analogs & derivatives. Biochem Biophys Res Commun 87(3):890;1979
enkephalin-Met, Ala(2)  61370-87-4 L-Methionine, N-(N-(N-(N-L-tyrosyl-D-alanyl)glycyl)-L-phenylalanyl)  Enkephalin, Methionine/*analogs & derivatives.
Pharma Action Analgesics, Opioid 		Biochem Biophys Res Commun 83(3):977;1978; Brain Res 146(2):392;1978; Brain Res Bull 1(6):583;1977; Experientia 34(11):1488;1978; Pharmacol Biochem Behav 5:691;1976; Science 196(4285):85;1977

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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