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Enkephalins

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Definition: One of the three major families of endogenous opioid peptides. The enkephalins are pentapeptides that are widespread in the central and peripheral nervous systems and in the adrenal medulla.  general or unspecified; prefer specifics   
Pharmacological Action Neurotransmitter Agents
See Also Receptors, Opioid
Examples Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalin, D-Penicillamine (2,5)- 		Other names Enkephalin
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
eribis peptide 94  0   *Enkephalins Receptors, Opioid, mu/agonists Receptors, Opioid, delta/agonists. Eur J Pharmacol 2011 Jan 25;651(1-3):146-51
enkephalinamide, cyclo(Nepsilon,Nbeta-carbonyl-Lys(2)-Dap(5))  0   *Enkephalins. Neuropeptides 2009 Jun;43(3):221-8
D-Ala2-D-Nle5-enkephalin-Arg-Phe  0   *Enkephalins. Regul Pept 2004 Oct 15;122(2):139-46
tyrosyl-(valyl-glycyl-phenylalanyl-alanyl)-OH  0   *Enkephalins. J Pharmacol Exp Ther 2003 Feb;304(2):827-32
3--carboxysalsolinol-Gly-Gly-Phe-Leu  0   *Enkephalins *Isoquinolines. Biochem Pharmacol 2002 May 15;63(10):1885-92
cysteinyldopaenkephalin  0   *Enkephalins. Biochim Biophys Acta 2000 Mar 16;1478(1):19-29
tyrosyl-arginyl-phenylalanyl-phenylaninamide  0   *Enkephalins *Oligopeptides. Pharm Res 1997 Dec;14(12):1780-5
tyrosyl-arginyl-phenylalanyl-norvalylamide  0   *Enkephalins *Oligopeptides. Pharm Res 1997 Dec;14(12):1780-5
enkephalinamide, cyclo(N,N'-carbonyl-lysyl(2,5))  0   *Enkephalins. J Pept Sci 1997 Jul-Aug;3(4):277-81
ONO 9902  0   *Enkephalins Neprilysin/antagonists & inhibitors Analgesics, Non-Narcotic. Bioorg Med Chem. 1998 Apr;6(4):441-63; Can J Anaesth 1996 Nov;43(11):1175-9
enkelytin  0   *Enkephalins *Peptide Fragments Protein Precursors. Eur J Biochem 1996 Feb 1;235(3):516-25
tyrosyl-D-alanyl-glycyl-methylphenylalanyl-N-propylglycinamide  0   *Enkephalins. Pharmacol Res 1995 May;31(5):269-73
enkephalin-Met, Cys(O2NH2)(2)  0   *Enkephalins. Gen Pharmacol 1995 Jul;26(4):799-808
enkephalin-Leu, Cys(O2NH2)(2)  0   *Enkephalins. Gen Pharmacol 1995 Jul;26(4):799-808
cyclo(lysyl-tyrosyl-methionyl-glycyl-phenylalanyl-prolyl)  0   *Enkephalins *Peptides, Cyclic. Biorg Khim 1995 Apr;21(4):275-81
tyrosyl-acetylornithinyl-glycyl-phenylalaninamide  0   *Oligopeptides Enkephalins. Fiziol Zh Im I M Sechenova 1994 May;80(5):95-8
IVS 46  0   *Enkephalins. Zh Vyssh Nerv Deiat Im I P Pavlova 1994 Jul-Oct;44(4-5):682-90
IVS 43  0   *Enkephalins. Zh Vyssh Nerv Deiat Im I P Pavlova 1994 Jul-Oct;44(4-5):682-90
enkephalin, Pen(2,5)-Ala(3)  151608-23-0   *Enkephalins. J Med Chem 1994 May 27;37(11):1572-7
enkephalin, Ala(2)-N-Phe(4)-Gly-ol  0   *Enkephalins. Anesth Analg 1993 Aug;77(2):265-74
enkephalin-Thr, Thr(2)-4-azido-Phe(4)-Leu(5)  0   *Azides *Enkephalins. J Comp Neurol 1992 Dec 8;326(2):229-44
enkephalinamide, Ala(2,5)  143791-43-9   *Enkephalins. J Med Chem 1992 Oct 30;35(22):4185-94
allatostatin  110119-33-0 Allatostatin  *Neuropeptides Enkephalins.
Pharma Action Hormone Antagonists 		Experientia 1992 Aug 15;48(8):758-61
enkephalin, 2,6-dimethyl-Tyr(1)-Pen(2,5)  137666-07-0   *Enkephalins. J Med Chem 1992 Feb 21;35(4):684-7
enkephalin, Pen(2,5)-4'-iodo-Phe(4)  135108-10-0   *Enkephalins. J Pharmacol Exp Ther 1991;258(3):1077
H-tyrosyl-cyclo(cysteinyl-phenylalanyl-penicillaminyl)-OH  117550-12-6   *Enkephalins Ligands. Int J Pept Protein Res 1991;37(3):224
enkephalin sulfonic acid, Ala(2)-Nle(5)  75829-10-6   *Enkephalins. Acta Physiol Hung;7(3):219
tyrosyl-arginyl-glycyl-4-nitrophenylalanyl-prolinamide  127627-13-8 L-Prolinamide, D-tyrosyl-L-arginylglycyl-4-nitro-L-phenylalanyl  *Enkephalins. Eur J Clin Pharmacol 1990;38(3):213
enkephalin, Pen(2,5)-4-chloro-Phe(4)  122507-47-5   *Enkephalins. Eur J Pharmacol 1990;177(1-2):99
tyrosyl-seryl(O-t-butyl)-glycyl-phenylalanyl-leucyl-threonine(O-t-butyl)  111035-57-5   *Oligopeptides Enkephalins. Eur J Pharmacol 1989;170(3):137
enkephalinamide, Met(2)-Pro(5)-(N(1,5))-galactopyranosyl  113350-05-3   *Enkephalins. EMBO J 1989;8(10):2925
EK 209  72732-46-8   *Enkephalins. Eur J Pharmacol 1989;166(3):453
enkephalinamide, Met(2)-Hyp(5)glucopyranosyl  121807-03-2   *Enkephalins. Neurosci Lett 1989;101(1):89
enkephalinamide, Met(2)-Hyp(5)galactopyranosyl  124076-39-7   *Enkephalins Glycopeptides. Experientia 1989;45(6):574
tyrosyl-alanylglycyl-phenylalanyl-cysteine S-butyl ester  94492-35-0   *Enkephalins. Endocrinol Exp (Bratisl) 1988;22(4):255
tyrosyl-alanyl-glycyl-phenylalanyl-cysteine S-ethyl ester  94492-33-8   *Enkephalins. Endocrinol Exp (Bratisl) 1988;22(4):255
enkephalin, Ala(2)-cysteamine(5)  99043-51-3   *Enkephalins. Int J Peptide Protein Res 1988;32(1):41
tyrosyl-methionyl(O)-glycyl-ethylphenylalanine-2-acetylhydrazide  98849-86-6   *Enkephalins. Jpn J Pharmacol 1988;47(4):409
enkephalin, Met(2)-ProNH2(5)(N(1.5)-glucopyranosyl)  113282-21-6   *Enkephalins. Int J Pept Protein Res 1988;31(5):474
peptide B  0   *Enkephalins *Protein Precursors. J Biol Chem 1988;263(25):12454
LY 164929  113573-18-5 LY 164929  *Enkephalins Ligands. Neuropeptides 1988;11(1):13
proenkephalin carboxyl-terminal peptide B  0   *Enkephalins. J Biol Chem 1988;263(5):2548
tyrosyl-alanyl glycyl-phenylalaninamide-propyl-phenylalaninamide-glycyl-alanyl-tyrosine  83916-02-3   *Enkephalins. Peptides 1987;8(3):431
biphalin  83916-01-2   *Enkephalins.
Pharma Action Analgesics 		Peptides 1987;8(3):431
enkephalinamide, Thr(2)-delta(3)Pro(5)  77217-02-8   *Enkephalins. Int J Pept Protein Res 1986;28(4):370
LY 190388  105496-35-3 D-Valine, N-(N-(N-(3-mercapto-N-L-tyrosyl-D-valyl)glycyl)-L-phenylalanyl)  *Enkephalins. Neuropeptides 1986;8(2):119
(H-Tyr-Lys-Gly-Phe-Glu-NH2)2  99571-07-0   *Peptides, Cyclic Enkephalins. FEBS Lett 1985;191(2):231
BW 942C  98311-64-9 L-Prolinamide, L-tyrosyl-gamma-(methylsulfinyl)-D-alpha-aminobutyrylglycyl-4-nitro-L-phenylalanyl-, monoacetate (salt)  *Enkephalins. Infect Immun 1985;48(3):754
enkephalin, Ala(2)-O-benzyl-Ser(5)  86248-85-3   *Enkephalins. Chung Kuo Yao Li Hsueh Pao 1985;6(1):3
enkephalinamide, Cys(2,5)  0   *Enkephalins. Int J Pept Protein Res 1984;23(5):462
enkephalin, Cys(2)-Pen(5)  0   *Enkephalins. Life Sci 1983;33 suppl 1:447
peptide E (adrenal medulla)  78355-50-7   *Enkephalins Protein Precursors. Peptides (Fayetteville) 1983;4(4):445
enkephalin, Pen(2)-Cys(5)  0   *Enkephalins. Life Sci 1983;32(22):2565
synenkephalin  85497-46-7 Synenkephalin  *Enkephalins *Protein Precursors. Nature 1983;302(5903):62
enkephalin, dehydro-Ala(3)  81851-82-3 L-Leucine, N-(N-(2,3-didehydro-N-(N-L-tyrosylglycyl)alanyl)-L-phenylalanyl)  *Enkephalins. Int J Pept Protein Res 1982;20(3):1999
enkephalinamide, Pen(2)-Cys(5)  0   *Enkephalins. Biochem Biophys Res Commun 1982;106(2):506
preproenkephalin  93443-35-7 Enkephalin, prepro  *Enkephalins *Protein Precursors. Nature 1982;295(5846):202
enkephalin, Ala(2)-N-pentyl-PheNH(4)  66229-24-1   *Enkephalins. Life Sci 1981;29(25):2617
enkephalin, Met(2)-Thz(5)-GlyNH2(3)  64889-79-8 Glycinamide, L-tyrosyl-D-methionyl-N-(2-(4-(aminocarbonyl)-3-thiazolidinyl)-2-oxo-1-(phenylmethyl)ethyl)-, (R-(R*,S*))  *Enkephalins *Thiazolidines. Eur J Pharmacol 1981;733(1):69
enkephalin, Thr(2)-Thz(5)-GlyNH2(3)  64889-80-1 Glycinamide, L-tyrosyl-D-threonyl-N-(2-(4-(aminocarbonyl)-3-thiazolidinyl)-2-oxo-1-(phenylmethyl)ethyl)-, (R-(R*,S*))  *Enkephalins *Thiazolidines. Eur J Pharmacol 1981;73(1):69
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