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Enzyme Inhibitors

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Definition: Compounds or agents that combine with an enzyme in such a manner as to prevent the normal substrate-enzyme combination and the catalytic reaction.  GEN only; prefer specifics   
Examples 14-alpha Demethylase Inhibitors; 5-alpha Reductase Inhibitors; 5-Lipoxygenase-Activating Protein Inhibitors; Adenosine Deaminase Inhibitors; Aromatase Inhibitors; Carbonic Anhydrase Inhibitors; Cholinesterase Inhibitors; Cyclooxygenase Inhibitors; Folic Acid Antagonists; Histone Deacetylase Inhibitors; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Integrase Inhibitors; Lipoxygenase Inhibitors; Monoamine Oxidase Inhibitors; Nucleic Acid Synthesis Inhibitors; Phosphodiesterase Inhibitors; Protease Inhibitors; Protein Kinase Inhibitors; Protein Synthesis Inhibitors; Proton Pump Inhibitors; Topoisomerase Inhibitors; Uncoupling Agents 		Other names Inhibitors, Enzyme
Substances having this pharmacologic action: 4-bromophenacyl bromide; butyl phosphorotrithioate; Amoxicillin-Potassium Clavulanate Combination; Tyrphostins; 2,4-diaminohypoxanthine; fenvalerate; 9-(tetrahydro-2-furyl)-adenine; zinc protoporphyrin; sodium arsenite; W 7; N,N-dimethylarginine; acifluorfen; 2-tert-butylhydroquinone; prunasin; 2,5-di-tert-butylhydroquinone; tele-methylhistamine; rhein; ethanolamine O-sulfate; herbimycin; succinylacetone; tetrathiomolybdate; protein phosphatase inhibitor-1; tetra(4-N-methylpyridyl)porphine; steroid delta-isomerase; bufalin; 4-hydroxyphenylglycine; tobacco tar; bicozamycin; protein phosphatase inhibitor-2; acyclovir triphosphate; 3-methoxybenzamide; 3-aminobenzamide; purpurogallin; ATPase inhibitory protein; uracil-DNA glycosylase inhibitor protein, B. subtilis bacteriophage; S-methylisothiopseudouronium; alpha-fluoromethylhistidine; CB 3717; dazoxiben; 3-O-methylcatechin; oxophenylarsine; imidazole; triamcinolone diacetate; maleic acid; 2-methyl-3-(4-(3-pyridinylmethyl)phenyl)-2-propenoic acid; tendamistate; neplanocin A; 3-chlorocatechol; urokinase inhibitor; pyrazole; 6-iodopenicillanic acid; calmidazolium; perilla alcohol; levulinic acid; neocarzinostatin chromophore; 8-aminoguanosine; tin protoporphyrin IX; angiotensin II, Sar(1)-Ile(5)-; 13-hydroperoxylinoleic acid; RV 538; N-methyldeoxynojirimycin; hexylglutathione; N-oleoylethanolamine; 5,6-dihydroxyindole; proteinase inhibitor II protein, plant; 5-iodotubercidin; ozagrel; digoxin-like factors; 3-deazaaristeromycin; triacsin C; 5-benzylacyclouridine; Sch 28080; monorden; 2-deoxy-2,3-dehydro-N-acetylneuraminic acid; concanamycin A; amonafide; M 79175; brodimoprim; pirmagrel; castanospermine; baicalin; N-cyclohexyl-N'-(4-dimethylamino-alpha-naphthyl)carbodiimide; ONO 2235; thiazole-4-carboxamide adenine dinucleotide; dazmegrel; 6-heptyne-2,5-diamine; tolrestat; furegrelate; SAN 58035; fostriecin; N(2)-(4-n-butylphenyl)-2'-deoxyguanosine 5'-triphosphate; heliodermin; isoliquiritigenin; bafilomycin A1; terbinafine; 7,7'-dimethoxy-(4,4'-bi-1,3-benzodioxole)-5,5'-dicarboxylic acid dimethyl ester; doxorubicin-iron complex; ribosomal protein L34; 6-anilino-5,8-quinolinedione; sulfometuron methyl; diphenyleneiodonium; N-(3-pyrene)maleimide; 3-mercaptopicolinic acid; adenosine 5'-methylenediphosphate; etiron; fluoranthene; 3-hydroxybenzylhydrazine; 5'-methylthioadenosine; monodansylcadaverine; 2-nitro-5-thiocyanobenzoic acid; 2-iodosobenzoic acid; pimagedine; blasticidin S; geldanamycin; propargylglycine; diacetylmonoxime; dipicolinic acid; hypericin; Vigabatrin; Acarbose; lawsone; juglone; thiosemicarbazide; benserazide, levodopa drug combination; S-Nitroso-N-Acetylpenicillamine; Permethrin; 3-beta-(2-(diethylamino)ethoxy)androst-5-en-17-one; surfactin peptide; 3-morpholino-sydnonimine; polyoxorim; Neuronal Apoptosis-Inhibitory Protein; Oseltamivir; Zanamivir; costunolide; honokiol; safingol; bis(4-nitrophenyl)phosphate; trilostane; bredinin; pyrazofurin; 7-ketocholesterol; Atovaquone; N(6)-(1-iminoethyl)lysine; 8-(4-chlorophenylthio)guanosine 3',5'-cyclic monophosphorothioate; 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole; phosphinothricin; 9-(2-hydroxy-3-nonyl)adenine; pervanadate; 3,3',4',5-tetrachlorosalicylanilide; acivicin; methodichlorophen; acetohydroxamic acid; baicalein; cyclopiazonic acid; Cyclosporine; Fleroxacin; Aphidicolin; Phenylglyoxal; Phenylmethylsulfonyl Fluoride; Phosphonoacetic Acid; Dichlororibofuranosylbenzimidazole; Digitalis Glycosides; Atractyloside; Chloromercuribenzoates; 4-Chloromercuribenzenesulfonate; Amanitins; Cimetidine; Clavulanic Acids; Benserazide; Azacitidine; Potassium Cyanide; Proadifen; Mycophenolic Acid; Nalidixic Acid; 4-Chloro-7-nitrobenzofurazan; Proscillaridin; Quinacrine; Quinidine; Rifampin; Rutamycin; Lithium Carbonate; Sodium Cyanide; Strophanthins; Sulbactam; Teniposide; Swainsonine; Annexin A5; 1-Deoxynojirimycin; Valproic Acid; Meglutol; 3-Mercaptopropionic Acid; 4-Hydroxycoumarins; Erythromycin Ethylsuccinate; Thapsigargin; 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Palmitic Acid; Staurosporine; Okadaic Acid; Trichloroepoxypropane; omega-N-Methylarginine; beta-Naphthoflavone; Buthionine Sulfoximine; NG-Nitroarginine Methyl Ester; Nitroarginine; 3-Iodobenzylguanidine; alpha-Methyltyrosine; Iodoacetic Acid; Sodium Azide; Clavulanic Acid; Norfloxacin; Novobiocin; o-Phthalaldehyde; Oligomycins; Omeprazole; Ouabain; Oxypurinol; Fenclonine; Pentachlorophenol; Medigoxin; Mercuribenzoates; Mersalyl; Methotrexate; Methylene Blue; Fusaric Acid; Digitoxin; Digoxin; Disulfiram; Coformycin; Benzoflavones; Acetyldigitoxins; Acetyldigoxins; Curcumin; Phencyclidine; Dicumarol; Brocresine; Hydroxychloroquine; Hydroxymercuribenzoates; Hydroxyurea; Cyclosporins; Cystamine; Metyrapone; Mitoguazone; Erythromycin Estolate; Allopurinol; Eflornithine; Iodoacetamide; Iodoacetates; Cantharidin; Carbidopa; Ethacrynic Acid; Ethidium; Amiodarone; Amitrole; Ethylmaleimide; Cardiac Glycosides; Aminooxyacetic Acid; Desipramine; Deslanoside; 3-acetylpyridine; glyphosate; phosphoramidic acid; conduritol epoxide; androsta-1,4,6-triene-3,17-dione; dicyclohexylamine; nikkomycin; 7,8-dichloro-1,2,3,4-tetrahydroisoquinoline; Cibacron Blue F 3GA; gabaculine; NSC 224131; nojirimycin; sulfoquinovosyl diglyceride; 4-amino-5-hexynoic acid; cytidylyl adenosine; daidzin; decitabine; protein kinase modulator; 8-((4-chlorophenyl)thio)cyclic-3',5'-AMP; alrestatin; methyl diethyldithiocarbamate; bromopyruvate; placental ribonuclease inhibitor; 4-amino-5-(4-methylphenyl)-7-(tert-butyl)pyrazolo(3,4-d)pyrimidine; Y 27632; caspase-activated DNase inhibitor; U 0126; alpha 2(I) collagen; PD 169316; Gckr protein, mouse; NB 506; SB 203580; farnesylthiosalicylic acid; marinobufagenin; 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one; alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide; FTI 277; synaptojanin; ruboxistaurin; nolatrexed; ISIS 5132; 2-mercaptoethylguanidine; marimastat; tyrphostin AG 1478; methyl arachidonylfluorophosphonate; N-(3-(aminomethyl)benzyl)acetamidine; 2-(allylthio)pyrazine; nitisinone; microcystin; 1843U89; tyrphostin 25; 7-nitroindazole; glucokinase regulatory protein; Go 6976; PGIP protein, plant; arachidonyltrifluoromethane; 4-amidinoindan-1-one 2'-amidinohydrazone; trehalose-6-phosphate; sodium-potassium ATPase inhibitory factor; pemetrexed; rottlerin; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one; Rum1 protein, S pombe; 2'-deoxy-2'-(fluoromethylene)cytidine; thiocitrulline; S-methylthiocitrulline; 3-chlorotyrosine; estrone-3-O-sulfamate; 4-((3-bromophenyl)amino)-6,7-dimethoxyquinazoline; olomoucine; deslorelin; trapoxin A; zopolrestat; methyl 2,5-dihydroxycinnamate; N-acetyl-S-farnesylcysteine; AG 127; PD 128042; bisindolylmaleimide I; ML 7; entacapone; aureobasidin A; Ro 31-8425; BOF 4272; 5-ethynyluracil; phosphoprotein phosphatase inhibitor 1; RB 101; 3,4,5-trihydroxybenzamidoxime; squalestatin 1; 4'-N-benzoylstaurosporine; miglustat; fantofarone; ICI 198583; tyrphostin 47; ridogrel; tyrphostin A23; ST 638; liarozole; calphostin complex; protein kinase inhibitor peptide; C6-(N1-methyl-1,2,3-trazolylmethylene)penem; N,N-dimethylsphingosine; FK 409; lavendustin A; rabeprazole; KN 62; lobucavir; KT 5926; Ro 31-7549; Ro 31-8220; N-acetylsphingosine; FR 74366; O(6)-benzylguanine; N(G)-iminoethylornithine; SQ 28603; beta-lactamase-inhibitor protein, Streptomyces; kifunensine; MDL 73811; tolcapone; 3,4-dihydroxybenzohydroxamic acid; N-(2-(methylamino)ethyl)-5-isoquinolinesulfonamide; etomoxir; antibiotic 1233A; manumycin; allosamidin; orlistat; tin mesoporphyrin; ranolazine; RS 5186; nafagrel; 2'-methyl-2'-deoxyidenecytidine; acetovanillone; ML 9; gemcitabine; pseudohypericin; fumonisin B1; nitecapone; KT 5720; bafilomycin A; cyanoginosin LR; mofegiline; phenethyl isothiocyanate; lansoprazole; calphostin C; calyculin A; resveratrol; erbstatin; ACTH (4-7), Pro-Gly-Pro-; atamestane; ajoene; 3-methyl-2-(3-pyridyl)-1-indoleoctanoic acid; Y 20811; staurosporine aglycone; furafylline; 6-(4-fluorophenyl)-2,3-dihydro-5-(4-pyridinyl)imidazo(2,1-b)thiazole; rebamipide; tautomycin; ponalrestat; ticarcillin-clavulanic acid; tazobactam; N-chlorotaurine; 6-methoxy-2-naphthylacetic acid; isbogrel; leflunomide; miglitol; emeriamine; cyclopentenyl cytosine; flurithromycin; brequinar; BM 15766; R 59022; 2,2'-thiodiethanol
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
endonuclease G inhibitor, Drosophila  0   *Drosophila Proteins Enzyme Inhibitors. J Biol Chem 2009 Mar 27;284(13):8337-48
ADC protein, human  EC 4.1.1.19   *Carboxy-Lyases Enzyme Inhibitors. PLoS One. 2009;4(8) (dup#10):e6858
RNH1 protein, human  0   *Carrier Proteins Enzyme Inhibitors.
Oaz3 protein, mouse  0   *Carrier Proteins Enzyme Inhibitors. Proc Natl Acad Sci U S A 2000 Apr 25;97(9):4808-13
PR-07 steroid  0   *Steroids Enzyme Inhibitors. Steroids. 2004 Jul;69(7):439-44
PR-01 steroid  0   *Monosaccharides *Steroids Enzyme Inhibitors. Steroids. 2004 Jul;69(7):439-44
GCKR protein, human  0   *Adaptor Proteins, Signal Transducing Enzyme Inhibitors Glucokinase. Mamm Genome 1995 Aug;6(8):532-6
AZIN1 protein, human  0   *Carrier Proteins Enzyme Inhibitors Ornithine Decarboxylase.
PPP1R14D protein, human  0   *Proteins Enzyme Inhibitors Phosphoprotein Phosphatases/antagonists & inhibitors. Biochem J 2004 Jan 1;377(Pt 1):171-81
NLRP4 protein, human  0   *Repressor Proteins Enzyme Inhibitors. J Biol Chem 2002 Sep 20;277(38):35333-40
ethyl 2-amino-6-bromo-4-(1-cyano-2-ethoxy-2-oxoethyl)-4H-chromene-3-carboxylate  0   *Benzopyrans *Nitriles Enzyme Inhibitors. Blood 2002 May 1;99(9):3461-4
PPP1R2P9 protein, human  0   *Proteins Enzyme Inhibitors Phosphoprotein Phosphatases/antagonists & inhibitors. Biochem Biophys Res Commun 2002 Mar 15;291(5):1293-6
Thrombostasin protein, Haematobia irritans  0   *Insect Proteins Enzyme Inhibitors. Mol Genet Genomics 2001 Oct;266(2):296-302
PAK1IP1 protein, human  0   *Intracellular Signaling Peptides and Proteins Enzyme Inhibitors. Proc Natl Acad Sci U S A 2001 May 22;98(11):6174-9
MBIP protein, human  0   *Intracellular Signaling Peptides and Proteins Enzyme Inhibitors. J Biol Chem 2000 Jul 14;275(28):21247-54
4-amino-1-octylquinaldinium  0   *Quinolines Enzyme Inhibitors. Cell Biochem Biophys 1999 ;31(3):285-94
PCSK1N protein, human  0   *Neuropeptides Enzyme Inhibitors. J Neurosci 2000 Jan 15;20(2):639-48
inhibitor-t protein, Drosophila  0   *Drosophila Proteins Enzyme Inhibitors. FEBS Lett 1998 Oct 30;438(1-2):131-6
J 104871  0   *Oxazoles *Naphthalenes Enzyme Inhibitors. Mol Pharmacol 1998 Jul;54(1):1-7
epostatin  0   *Alanine *Amides *Ethers, Cyclic Enzyme Inhibitors. J Antibiot (Tokyo) 1998 Mar;51(3):253-60
valine-pyrrolidide  0   *Pyrroles *Valine Enzyme Inhibitors. Diabetes 1998 May;47(5):764-9
4-(phenylamino)-7H-pyrrolo(2,3-d)pyrimidine  0   *Pyrimidines *Pyrroles Enzyme Inhibitors. J Cancer 1998 Mar 30;76(1):154-63
SaI14 protein, Streptomyces aureofaciens  0   *Bacterial Proteins *Carrier Proteins Enzyme Inhibitors. J Bacteriol 1998 Mar;180(6):1582-5
ITF1671 protein, synthetic  0   *Oligopeptides Enzyme Inhibitors. Drug Des Discov 1996 Apr;13(3-4):63-74
DIT33 protein, Dirofilaria immitis  0   *Biological Markers *Helminth Proteins Enzyme Inhibitors. Parasitology 1996 Mar;112(Pt 3):331-8
dihydronovobiocin  29826-16-2   Novobiocin/*analogs & derivatives Enzyme Inhibitors. Biochemistry 1996 Apr 16;35(15):5083
SK&F 104976  136209-43-3   Lanosterol/*analogs & derivatives Enzyme Inhibitors. J Biol Chem 1991;266(30):20070
mycophenolate mofetil  128794-94-5   Mycophenolic Acid/*analogs & derivatives Anti-Inflammatory Agents, Non-Steroidal Antineoplastic Agents Dermatologic Agents Enzyme Inhibitors IMP Dehydrogenase/antagonists & inhibitors Prodrugs.
Pharma Action Immunosuppressive Agents 		JAMA 1990;263(9):1184CELLCEPT; MYCOPHENOLATE MOFETIL; MYCOPHENOLATE MOFETIL HYDROCHLORIDE
barstar protein, Bacillus amyloliquefaciens  37328-61-3 Nuclease inhibitor, barstar  *Bacterial Proteins Enzyme Inhibitors Ribonucleases/antagonists & inhibitors. J Mol Biol 1988;202(4):913
ornithine decarboxylase antizyme inhibitor  0   *Carrier Proteins Enzyme Inhibitors. Methods Enzymol 1983;94:185
ornithine decarboxylase antizyme  0   *Proteins Enzyme Inhibitors Xenopus Proteins Zebrafish Proteins. J Cell Physiol 1981;107(2):209
Rnh1 protein, rat  0   *Carrier Proteins Enzyme Inhibitors. Hoppe Seylers Z Physiol Chem 1980;361(12):1781
fludarabine  21679-14-1 9H-purin-6-amine, 9-beta-D-arabinofuranosyl-2-fluoro  Vidarabine/*analogs & derivatives DNA (Cytosine-5-)-Methyltransferase/antagonists & inhibitors Enzyme Inhibitors Myeloablative Agonists.
Pharma Action Antineoplastic Agents 		Cancer Res 1980;40(5):1405
ATPase inhibitory protein, aprotinin  0   *Proteins Enzyme Inhibitors. Febs Lett 1980;111(1):87

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