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Epidermal Growth Factor

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Definition: A 6-kDa polypeptide growth factor initially discovered in mouse submaxillary glands. Human epidermal growth factor was originally isolated from urine based on its ability to inhibit gastric secretion and called urogastrone. EPIDERMAL GROWTH FACTOR exerts a wide variety of biological effects including the promotion of proliferation and differentiation of mesenchymal and epithelial cells.     
See Also Anti-Ulcer Agents; Gastrointestinal Agents; Receptor, Epidermal Growth Factor 		Other names Urogastrone; Epidermal Growth Factor-Urogastrone; EGF; beta Urogastrone; Growth Factors, Epidermal; Growth Factor-Urogastrone, Epidermal; Growth Factor, Epidermal; beta-Urogastrone; Human Urinary Gastric Inhibitor; Epidermal Growth Factors
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
CRELD2 protein, mouse  0   *Cell Adhesion Molecules *Extracellular Matrix Proteins Epidermal Growth Factor. FEBS Lett. 2011 Aug 4;585(15):2481-7
Peptide growth factors deficiency  0   *Werner Syndrome Epidermal Growth Factor/deficiency Insulin-Like Growth Factor I/deficiency.
peptabody-EGF  0   *Epidermal Growth Factor. Int J Cancer 2006 Nov 15;119(10):2455-63
LRP protein, Holotrichia diomphalia  0   *Insect Proteins Epidermal Growth Factor. J Immunol 2006 Aug 1;177(3):1838-45
68Ga-DOTA-hEGF  0   *Organometallic Compounds Epidermal Growth Factor/*analogs & derivatives Gallium Radioisotopes. J Nucl Med 2005 Nov;46(11):1881-8
CRELD2 protein, human  0   *Cell Adhesion Molecules *Extracellular Matrix Proteins Epidermal Growth Factor. Neurochem 2005 Dec;95(6):1585-96
E1-INT  0   *Epidermal Growth Factor *Gastrins. Curr Opin Investig Drugs 2005 Oct;6(10):1037-42
gigantoxin I, Stichodactyla gigantea  0   *Cnidarian Venoms *Epidermal Growth Factor. Curr Pharm Des. 2004;10(31):3885-92
technetium 99m HYNIC-human epidermal growth factor  0   *Epidermal Growth Factor *Organotechnetium Compounds. Nucl Med Commun 2005 Feb;26(2):147-53
Emr4 protein, rat  0   *Receptors, Cell Surface Epidermal Growth Factor. Immunogenetics 2004 Dec;56(9):679-81
Emr1 protein, rat  0   *Receptors, Cell Surface Epidermal Growth Factor. Immunogenetics 2004 Dec;56(9):679-81
Cd97 protein, rat  0   *Receptors, Cell Surface Antigens, CD Epidermal Growth Factor. Immunogenetics 2004 Dec;56(9):679-81
Scube3 protein, mouse  0   *Glycoproteins Epidermal Growth Factor Protein Sorting Signals. J Biol Chem 2004 Sep 3;279(36):37485-90
SCUBE3 protein, human  0   *Calcium-Binding Proteins Epidermal Growth Factor Protein Sorting Signals. J Biol Chem 2004 Sep 3;279(36):37485-90
Cd97 protein, mouse  0   *Membrane Glycoproteins Epidermal Growth Factor Antigens, CD.
Tdgf1 protein, mouse  0   *Epidermal Growth Factor *Membrane Glycoproteins *Neoplasm Proteins Growth Substances Tumor Markers, Biological.
Fat3 protein, rat  0   *Cadherins *Epidermal Growth Factor.
111In-DTPA-human epidermal growth factor  0   *Epidermal Growth Factor Pentetic Acid/*analogs & derivatives Indium. Nucleic Acids Res Suppl 2003;(3):1469-78
fat3 protein, C elegans  0   *Epidermal Growth Factor *Cadherins *Caenorhabditis elegans Proteins. Genetics 2003 Feb;163(2):581-9
CRELD1 protein, human  0   *Cell Adhesion Molecules *Extracellular Matrix Proteins Epidermal Growth Factor. Gene 2002 Jun 26;293(1-2):47-57
Emr4 protein, mouse  0   *Epidermal Growth Factor. Biochem J 1997 Dec 1;328(Pt 2):593-8; J Biol Chem 2002 Aug 9;277(32):29283-93
FAT3 protein, human  0   *Epidermal Growth Factor *Cadherins. Biochem Biophys Res Commun 2002 Feb 1;290(4):1260-6
Scube2 protein, mouse  0   *Intercellular Signaling Peptides and Proteins Epidermal Growth Factor Protein Sorting Signals. Mech Dev 2001 Apr;102(1-2):209-11
epigen  0   *Epidermal Growth Factor. J Biol Chem 2001 May 25;276(21):18265-71
EGF-genistein  0   *Epidermal Growth Factor *Genistein. Methods Mol Biol 2001;166:193-218
Polydom protein, mouse  0   *Proteins C-Reactive Protein Epidermal Growth Factor von Willebrand Factor Extracellular Matrix Proteins. Biochem J 2000 Nov 15;352 Pt 1():49-59
cetuximab  0   *Antibodies, Monoclonal Epidermal Growth Factor Receptor, Epidermal Growth Factor.
Pharma Action Antineoplastic Agents 		JAMA 2000 Jul 19;284(3):293-5ERBITUX
epidermal growth factor--dextran-tyrosine conjugate  0   *Dextrans *Epidermal Growth Factor Drug Carriers. Int J Mol Med 1998 Apr;1(4):693-702
Humatrix  0   *Epidermal Growth Factor *Insulin-Like Growth Factor I Gels. Cancer Lett 1998 Jan 30;123(2):215-26
oep protein, zebrafish  0   *Transcription Factors *Homeodomain Proteins *Zebrafish Proteins Epidermal Growth Factor. Cell 1998 Jan 23;92(2):241-51
technetium Tc 99m epidermal growth factor  0   *Epidermal Growth Factor *Organotechnetium Compounds. J Pept Res 1997 Nov;50(5):393-401
HmEGFL-1 protein, Herdmania momus  0   *Epidermal Growth Factor Chordata, Nonvertebrate. Dev Dyn 1997 Nov;210(3):264-73
biregulin  0   *Epidermal Growth Factor. J Biol Chem 1995 Apr 21;270(16):9585-9
UBQLN1 protein, human  0   *Carrier Proteins *Cell Cycle Proteins Epidermal Growth Factor Nuclear Proteins. Biochem Biophys Res Commun 1997 Aug 18;237(2):245-50; Mol Cell 1999 Oct;4(4):619-25
epidermal growth factor-like protein, S(1-5)  0   *Epidermal Growth Factor. Biochem Biophys Res Commun 1997 Aug 18;237(2):245-50
CALEB protein, chicken  0   *Epidermal Growth Factor *Membrane Glycoproteins *Nerve Tissue Proteins *Avian Proteins. J Cell Biol 1997 Feb 24;136(4):895-906
PG10.2 protein, rat  0   *Eye Proteins *Cell Adhesion Molecules Epidermal Growth Factor. Brain Res Mol Brain Res 1996 Sep 5;41(1-2):269-78
epidermal growth factor (1-53)  0   *Epidermal Growth Factor *Peptide Fragments. Drug Metab Dispos 1996 Jan;24(1):96-104
epidermal growth factor (1-48)  0   *Epidermal Growth Factor *Peptide Fragments. Drug Metab Dispos 1996 Jan;24(1):96-104
epidermal growth factor (33-42)  0   *Epidermal Growth Factor *Peptide Fragments. J Biol Chem 1996 Oct 18;271(42):26179-86
CD97 protein, human  0   *Antigens, CD Epidermal Growth Factor. J Immunol 1995 Aug 15;155(4):1942-50
fibrillin protein, Podocoryne carnea  0   *Extracellular Matrix Proteins Antigens Epidermal Growth Factor. Dev Biol 1995 Jun;169(2):662-72
epiregulin  0   *Epidermal Growth Factor. J Biol Chem 1995 Mar 31;270(13):7495-500
epidermal growth factor, Lys(3)-Tyr(22)  0   *Epidermal Growth Factor. Biochemistry 1993 Aug 10;32(31):7893-7903
betacellulin  0   *Intercellular Signaling Peptides and Proteins Epidermal Growth Factor. Biochem Biophys Res Commun 1993 Feb 15;190(3):1173-9
E 6010  122007-85-6   *Epidermal Growth Factor Tissue Plasminogen Activator. Jpn J Pharmacol 1992 Mar;58(3):309-19
spi protein, Drosophila  148175-53-5   *Epidermal Growth Factor *Membrane Proteins *Drosophila Proteins Transforming Growth Factor alpha. Genes Dev 1992 Aug;6(8):1503-17
Lin-3 protein, C elegans  148412-70-8   *Epidermal Growth Factor *Caenorhabditis elegans Proteins. Nature 1992 Aug 6;358(6386):470-6
epidermal growth factor-dextran conjugate  0   *Dextrans *Epidermal Growth Factor Drug Carriers. Int J Cancer 1991;47(3):439
Ly64 protein, mouse  0   *Antigens, Surface *Epidermal Growth Factor Mucins. J Biol Chem 1990;265(9):4962
urogastrone, Lys-beta  121684-87-5   *Epidermal Growth Factor. Aust J Biol Sci 1988;41(4):463
fibropellin protein, sea urchin  0   *Epidermal Growth Factor *Extracellular Matrix Proteins Sea Urchins. J Mol Evol 1989;29(4):314
exogastrula-inducing peptide D, Anthocidaris crassispina  120365-36-8   *Invertebrate Hormones Epidermal Growth Factor. Cell Differ Dev 1989;26(1):53
exogastrula-inducing peptide A, Anthocidaris crassispina  120365-34-6   *Invertebrate Hormones Epidermal Growth Factor. Cell Differ Dev 1989;26(1):53
exogastrula-inducing peptide C, Anthocidaris crassispina  124585-18-8   *Invertebrate Hormones Epidermal Growth Factor. Biochim Biophys Acta 1989;999(1):24
epidermal growth factor (32-48), Cys-SO3H(33,42)  0   *Epidermal Growth Factor. Proc West Pharmacol Soc 1984;27:273
epidermal growth factor-ricin complex  0   *Epidermal Growth Factor *Ricin. Biochem Biophys Res Commun 1984;124(2):551
epidermal growth factor precursor  0   *Epidermal Growth Factor *Protein Precursors. Proc Natl Acad Sci USA 1984;81(17):5360
Pseudomonas exotoxin-epidermal growth factor conjugate  0   *Epidermal Growth Factor *Exotoxins Pseudomonas. J Virol 1984;51(3):650
epidermal growth factor receptor related protein, human  0   *Glycoproteins Epidermal Growth Factor Receptor, Epidermal Growth Factor. Science 1984;224(4646):294
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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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