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Epinephrine

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Definition: The active sympathomimetic hormone from the ADRENAL MEDULLA. It stimulates both the alpha- and beta- adrenergic systems, causes systemic VASOCONSTRICTION and gastrointestinal relaxation, stimulates the HEART, and dilates BRONCHI and cerebral vessels. It is used in ASTHMA and CARDIAC FAILURE and to delay absorption of local ANESTHETICS.     
Pharmacological Action Adrenergic alpha-Agonists; Adrenergic beta-Agonists; Bronchodilator Agents; Mydriatics; Sympathomimetics; Vasoconstrictor Agents
See Also Receptors, Adrenergic 		Other names Adrenaline; Hydrogen Tartrate, Epinephrine; Hydrochloride, Epinephrine; Hydrochloride, Adrenaline; Epinephrine, Racemic; Bitartrate, Epinephrine; Bitartrate, Adrenaline; Vaponefrin; Racepinephrine; Racemic Epinephrine; Micronephrine; Micronefrin; Medihaler-Epi; Lyophrin; Epitrate; Epinephrine Hydrogen Tartrate; Epinephrine Hydrochloride; Epinephrine Bitartrate; Bird Brand of Racepinefrine Hydrochloride; Allergan Brand of Adrenaline HydrochlorideDrugs* : SUS-PHRINE SULFITE-FREE; LIDOCAINE HYDROCHLORIDE AND EPINEPHRINE; PROCAINE HYDROCHLORIDE W/ EPINEPHRINE; EPI E Z PEN JR; IONTOCAINE; PRILOCAINE HYDROCHLORIDE AND EPINEPHRINE BITARTRATE; XYLOCAINE DENTAL WITH EPINEPHRINE; XYLOCAINE W/ EPINEPHRINE; BRONITIN MIST; ADRENACLICK; LIDOSITE TOPICAL SYSTEM KIT; LIDOCATON; EPINEPHRINE; CITANEST FORTE; EPIPEN; MEDIHALER-EPI; PRIMATENE MIST; EPIPEN E Z PEN; TWINJECT 0.15; LIDOCAINE HYDROCHLORIDE W/ EPINEPHRINE
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
isoprinaline  0   Epinephrine/*analogs & derivatives. J Chromatogr A. 2005 Dec 9;1098(1-2):166-71
adrenalinequinone  0   *Quinones Epinephrine/*analogs & derivatives. Bioorg Med Chem Lett. 2005 Nov 1;15(21):4671-80
tyroscherin  0   *Fatty Alcohols Epinephrine/*analogs & derivatives. J Antibiot (Tokyo) 2004 Oct;57(10):634-8
2-fluoroepinephrine  0   Epinephrine/*analogs & derivatives. J Med Chem 2000 Apr 20;43(8):1611-9
6-fluoroepinephrine  0   Epinephrine/*analogs & derivatives. J Med Chem 2000 Apr 20;43(8):1611-9
LET, anesthetic  0   *Epinephrine *Lidocaine *Tetracaine. Pediatrics 1998 Apr;101(4 Pt 1):730-1
epinephrine transporter, Rana catesbeiana  0   *Amphibian Proteins Epinephrine Nerve Tissue Proteins. J Neurosci 1997 Apr 15;17(8):2691-702
6-hydroxycatecholine  0   Epinephrine/*analogs & derivatives. Biochem Biophys Res Commun 1996 Nov 1;128(1):187-92
AZ 002  0   Epinephrine/*analogs & derivatives. Jpn J Pharmacol 1995 Nov;69(3):251-8
4-pivaloylepinephrine  91264-45-8   Epinephrine/*analogs & derivatives. J Pharm Biomed Anal 1992 Jun;10(6):465-71
3-pivaloylepinephrine  144750-97-0   Epinephrine/*analogs & derivatives. J Pharm Biomed Anal 1992 Jun;10(6):465-71
1-(3,4-dihydroxyphenyl)-1,2-diaminoethane  132261-26-8   Epinephrine/*analogs & derivatives. Resuscitation 1990;20(3):243
alpha-methylepinephrine dipivalate  81497-25-8   Epinephrine/*analogs & derivatives. Exp Eye Res 1990;51(5)::537
ICI 116258  102904-11-0   Epinephrine/*analogs & derivatives. Biochem Soc Trans 1986;14(2):388
ICI 125436  67631-88-3   Epinephrine/*analogs & derivatives. Biochem Soc Trans 1986;14(2):388
epinephrine glucuronide  54964-61-3   Epinephrine/*analogs & derivatives. Life Sci 1985;37(16):1469
3,4-diisovaleryl adrenaline  92634-50-9 Butanoic acid, 3-methyl-, (R)  Epinephrine/*analogs & derivatives. Exp Eye Res 1984;38(6):621
3,4-diisovaleryl adrenalone  92634-49-6 Butanoic acid, 3-methyl-, (11beta,16alpha)  Epinephrine/*analogs & derivatives. Exp Eye Res 1984;38(6):621
adrenalone  99-45-6   Epinephrine/*analogs & derivatives.
Pharma Action Hemostatics ; Vasoconstrictor Agents 		J Biol Chem 1984;259(1):354
suprexon  0   *Epinephrine *Guanethidine Drug Combinations Ophthalmic Solutions. Klin Monatsbl Augenheilkd 1983;183(1):17
N,N-dimethylepinephrine  38522-73-5   Epinephrine/*analogs & derivatives Choline O-Acetyltransferase/antagonists & inhibitors. Proc Natl Acad Sci USA 1983;80(8):2107
epinephrine sulfate  77469-50-2 1,2-Benzenediol, 4-(1-hydroxy-2-(methylamino)ethyl)-, mono(hydrogen sulfate) (ester), (R)  Epinephrine/*analogs & derivatives. Eur Heart J 1982; 3(suppl C):3
TEC solution  82824-07-5 8-Azabicyclo(3.2.1)octane-2-carboxylic acid, 3-(benzoyloxy)-8-methyl-, methyl ester, (1R-(exo,exo))-, mixt. with 2-(dimethylamino)ethyl 4-(butylamino)benzoate and (R)-4-(1-hydroxy-2-(methylamino)ethyl)-1,2-benzenediol  *Cocaine *Epinephrine *Tetracaine.
Pharma Action Anesthetics, Local ; Anesthetics, Combined 		Ann Emerg Med 1982;11(6):307
alpha-methylepinephrine  10329-60-9   Epinephrine/*analogs & derivatives. Eur J Pharmacol 1981;69(1):95
Levorenone  54958-67-7 Acetamide, 2-(diethylamino)-N-(2,6-dimethylphenyl)-, mixt. with (R)-4-(1-hydroxy-2-(methylamino)ethyl)-1,2-benzenediol  *Epinephrine *Lidocaine Drug Combinations. Bull Soc Belge Ophtalmol 1979;185:99LIGNOSPAN STANDARD; LIGNOSPAN FORTE
epinephryl borate  5579-16-8 1-epinephrine-3,4-cyclic borate  Epinephrine/*analogs & derivatives.
Pharma Action Sympathomimetics 		Klin Monatsbl Augenheilk 172(4):569;1978
adrenaline sulfate  52455-32-0   *Epinephrine. Biochem J 174(3):777;1978
pilaren  60996-13-6 2(3H)-Furanone, 3-ethyldihydro-4-((1-methyl-1H-imidazol-5-yl)methyl)-, (3S-cis)-, mixt. with (R)-4-(1-hydroxy-2-(methylamino)ethyl)-1,2-benzenediol  *Epinephrine *Pilocarpine Drug Combinations. Wien Med Wochenschr 20(127):636;1977
dipivefrin  52365-63-6 Propanoic acid, 2,2-dimethyl-, 4-(1-hydroxy-2-(methylamino)ethyl)-1,2-phenylene ester, (+-)  Epinephrine/*analogs & derivatives.
Pharma Action Adrenergic Agonists 		Acta Soc Ophthalmol Jpn 81(8):1036;1977; Am J Ophthalmol 1979;88(6):1013; Am J Ophthalmol 87(2):193;1979; Am J Ophthalmol 87(2):196;1979; Am J Vet Res 39(1):83;1978; Arch Ophthalmol 1979;97(10):1865; Arch Ophthalmol 1979;97(10):1937; Arch Ophthalmol 1980;98(2):350; Arch Ophthalmolog 95(12):2157;1977; J Pharm Exp Ther 203(2):442;1977; Klin Monatsbl Augenheick 172(4):565;1978; Klin Monatsbl Augenheilk 1979;175(1):DIPIVEFRIN HYDROCHLORIDE; PROPINE; AKPRO
N-methylepinephrine  554-99-4   Epinephrine/*analogs & derivatives. Am J Psychiatry 135(7):867;1978; Naunyn Schmiedebergs Arch Pharmacol 293(3):225;1976

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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