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Estrone

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Definition: An aromatized C18 steroid with a 3-hydroxyl group and a 17-ketone, a major mammalian estrogen. It is converted from ANDROSTENEDIONE directly, or from TESTOSTERONE via ESTRADIOL. In humans, it is produced primarily by the cyclic ovaries, PLACENTA, and the ADIPOSE TISSUE of men and postmenopausal women.     
Pharmacological Action Estrogens
Examples Hydroxyestrones 		Other names Wehgen; Vortech Brand of Estrone; Unigen; Kestrone; Hyrex Brand of Estrone; Hauck Brand of Estrone; Folliculin; Estrone, (9 beta)-Isomer; Estrone, (8 alpha)-Isomer; Estrone, (+-)-Isomer; EstrovarinDrugs* : ESTRONE; ESTROGENIC SUBSTANCE; THEELIN; NATURAL ESTROGENIC SUBSTANCE-ESTRONE
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
technetium 99m polyglutamate 3-aminoethyl estradiol  0   *Polyglutamic Acid *Organotechnetium Compounds Estrone/*analogs & derivatives. Eur J Nucl Med Mol Imaging 2007 Mar;34(3):354-62
3-hydroxy-2-adamantyl(1)-4-methyl-estra-1,3,5(10)-17-one  0   Adamantane/*analogs & derivatives Estrone/*analogs & derivatives. J Pharmacol Exp Ther 2006 Nov;319(2):543-50
F90927  0   Estrone/*analogs & derivatives. Br J Pharmacol 2006 Apr;147(7):772-82
2-ethyl-16-((3-pyridylmethylamino)carbonylmethyl)estrone  0   Estrone/*analogs & derivatives 17-Hydroxysteroid Dehydrogenases/antagonists & inhibitors. J Med Chem 2005 Apr 21;48(8):2759-62
N-(pyridin-3-ylmethyl)estrone-16-methylcarboxamide  0   *Pyridines Estrone/*analogs & derivatives 17-Hydroxysteroid Dehydrogenases/antagonists & inhibitors. J Med Chem 2006 Feb 23;49(4):1325-45
(3b,5b,7a,12a)-7,12-dihydroxy-3-(2-((4-((11b,17b)-17-hydroxy-3-oxo-17-prop-1-ynylestra-4,9-dien-11-yl) phenyl)(methyl)amino)ethoxy)cholan-24-oic acid  0   *Cholic Acids Estrone/*analogs & derivatives. J Pharmacol Exp Ther. 2005 Jul;314(1):191-200
3-benzyloxy-16-((N-methyl-N-phenylamino)methylidene)estra-1,3,5(10)-trien-17-one  0   Estrone/*analogs & derivatives. Acta Crystallogr C. 2004 Nov;60(Pt 11):o813-4
9,11-seco-estra-1,3,5(10)-trien-11-oic acid  0   Estrone/*analogs & derivatives. Bioorg Med Chem Lett. 2005 Jan 3;15(1):99-102
6-(3-Hydroxy-17-oxoestra-1,3,5(10)-trien-7beta-yl)hexanenitrile  0   *Nitriles Estrone/*analogs & derivatives. Acta Crystallogr C. 2004 Feb;60(Pt 2):o130-2
2-difluoromethyloestrone 3-O-sulfamate  0   Estrone/*analogs & derivatives. Biochem Biophys Res Commun 2004 Apr 23;317(1):169-75
piperazinyl estrone  0   Estrone/*analogs & derivatives. Yao Xue Xue Bao. 2003 Mar;38(3):161-4
3-pyrrolidino-estra-1,3,5(10)-triene-6,17-dione  0   Estrone/*analogs & derivatives. Pharmazie 2002 Dec;57(12):808-13
2-adamantylestra-1,3,5(10)-trien-3-ol-17-one  0   Adamantane/*analogs & derivatives Estrone/*analogs & derivatives. Stroke 2002 Oct;33(10):2485-91
16,16-dimethylhomo-B-nor-8-isoestrone  0   Estrone/*analogs & derivatives. Bioorg Khim 2002 May-Jun;28(3):242-50
17-benzyl-17-hydroxy-3-methoxyestra-1,3,5(10)-trien-16-one  0   Estrone/*analogs & derivatives. Acta Crystallogr C 2002 Mar;58( Pt 3):o172-3
estrone-3-O-yl-acyl-Tyr-Arg-OH  0   Estrone/*analogs & derivatives. Steroids 2001 Nov;66(11):811-5
4-hydroxy-1,3,5(10),8,9-estratetraen-17-one  0   Estrone/*analogs & derivatives. Chem Res Toxicol 2001 Jun;14(6):754-63
2-hydroxy-1,3,5(10),8,9-estratetraen-17-one  0   Estrone/*analogs & derivatives. Chem Res Toxicol 2001 Jun;14(6):754-63
3-hydroxy-1,3,5(10),8,9-estratetraen-17-one  0   Estrone/*analogs & derivatives. Chem Res Toxicol 2001 Jun;14(6):754-63
2-ethylestrone-3-O-sulfamate  0   Estrone/*analogs & derivatives. Cancer Res 2000 Oct 1;60(19):5441-50
2-methoxyoestrone-3-O-sulphamate  0   Estrone/*analogs & derivatives. Int J Cancer 2000 Mar 1;85(5):584-9
15-hydroxyestrone  0   Estrone/*analogs & derivatives. Steroids 1999 Aug;64(8):551-7
estrone oxime 3-O-sulfamate  0   *Oximes Estrone Alkyl and Aryl Transferases. J Med Chem 1999 Aug 12;42(16):3188-92
estrone oxime  0   *Oximes Estrone. J Med Chem 1999 Aug 12;42(16):3188-92
8,9-dehydroestrone sulfate  0   Estrone/*analogs & derivatives. J Clin Endocrinol Metab 1999 Jun;84(6):2020-7
delta-8-estrone sulfate  0   Estrone/*analogs & derivatives Estrogens, Conjugated (USP). J Soc Gynecol Investig 1998 May-Jun;5(3):156-60
oleoyl-estrone  0   *Oleic Acids Estrone/*analogs & derivatives Drug Carriers.
Pharma Action Anti-Obesity Agents 		Int J Obes Relat Metab Disord 1997 Sep;21(9):789-95
3-(beta-ethylaminoethoxy)-delta-1,3,5-estratriene-17-one  0   Estrone/*analogs & derivatives. J Steroid Biochem Mol Biol 1996 Sep;59(1):49-54
11-oxoestrone-3-acetate-17-ethyleneketal  0   *Spiro Compounds Estrone/*analogs & derivatives. Steroids 1995 Dec;60(12):809-11
hormonin  79275-73-3   *Estradiol *Estriol *Estrone Drug Combinations Tablets Estrogen Replacement Therapy. Eur J Vasc Endovasc Surg 1996 Apr;11(3):347-8
4',17-dioxo-5'H-estra-1(10),4-dieno(3,2-b)furan  0   Estrone/*analogs & derivatives Embryo Implantation. Arch Pharm (Weinheim) 1996 Feb;329(2):61-5
ZK 114863  0   Estrone/*analogs & derivatives. Steroids 1995 Feb;60(2):234-8
17-oxoestra-1,3,5(10)-trien-3-ylmethanesulfonic acid  0   *Mesylates Estrone/*analogs & derivatives. Steroids 1995 Mar;60(3):299-306
3-hydroxy-17--oxoestra-1,3,5(10)-trien-15-yl-2'-acetamido-2'-deoxyglucopyranoside  0   Estrone/*analogs & derivatives Glucosamine/*analogs & derivatives. Steroids 1995 Mar;60(3):277-84
estra-1,3,5(10)-trien-17-one-3-amine  0   Estrone/*analogs & derivatives. J Steroid Biochem Mol Biol 1995 Mar;52(3):281-6
estra-1,3,5(10)-trien-17-one-3-thiol  0   Estrone/*analogs & derivatives. J Steroid Biochem Mol Biol 1995 Mar;52(3):281-6
estrone-3-O-sulfamate  148672-09-7   Estrone/*analogs & derivatives.
Pharma Action Enzyme Inhibitors 		J Steroid Biochem Mol Biol 1994 Jul;50(1-2):101-4
3-hydroxyestra-1,3,5(10)-trien-17-one 6-N-(epsilon-biotinyl)caproamide  0   Biotin/*analogs & derivatives Estrone/*analogs & derivatives. Bioconjug Chem 1994 Mar-Apr;5(2):167-71
3-aminoethylestrone  142062-08-6   Estrone/*analogs & derivatives. J Pharm Sci 1994 Mar;83(3):328-31
estra-1(10),4-diene-2,3,17-trione  40551-33-5   Estrone/*analogs & derivatives. Chem Res Toxicol 1994 Jan-Feb;7(1):68-72
16-methoxymethylene estrone  150585-09-4   Estrone/*analogs & derivatives. Steroids 1993 May;58(5):234-8
estrone-3-methylthiophosphonate  71142-69-3   Estrone/*analogs & derivatives. Cancer Res 1993 Jan 15;53(2):298-303
6-hydroxy-D-homo-8-isoestrone methyl ether  150490-87-2   *Homosteroids Estrone/*analogs & derivatives. Biull Eksp Biol Med 1992 Jul;114(8):148-50
3-hydroxy-17-oxoestra-1,3,5(10)-trien-11-yl acetate  134761-89-0   Estrone/*analogs & derivatives. Acta Crystallogr C 1991;47(Pt 5):1094
4-bromo-3-methoxy-2-nitro-1,3,5(10)-estratriene-17-one  126291-42-7   *Nitro Compounds Estrone/*analogs & derivatives. Steroids 1989;54(4):441
3,4-dimethoxy-1-nitro-1,3,5(10)-estratrien-17-one  126291-41-6   *Nitro Compounds Estrone/*analogs & derivatives. Steroids 1989;54(4):441
9-hydroxyestrone-3-acetate-11-nitrate  33767-88-3   Estrone/*analogs & derivatives. Probl Endokrinol (Mosk) 1988;34(4):72
9-hydroxyestrone-11-nitrate  105801-89-6   Estrone/*analogs & derivatives. Probl Endokrinol (Mosk) 1988;34(4):72
estrone-naloxone azine  91712-59-3   Estrone/*analogs & derivatives Naloxone/*analogs & derivatives. Natl Inst Drug Abuse Res Monogr Ser 1986;75:45
16,16-dimethyl-D-homo-8-isoestrone methyl ester  108789-49-7   Estrone/*analogs & derivatives. Vopr Med Khim 1987;33(2):65
5-(2-methylene estrone 3-methyl ether)-3,3,10,10-tetramethyl-1,2-dithia-5,8-diazabicyclodecane  108736-70-5   Estrone/*analogs & derivatives. Int J Rad Appl Instrum (B) 1987;14(1):63
16,17-pyrazoleestrone  3460-91-1 1'H-Estra-1,3,5(10)-trieno(17,16-c)pyrazol-3-ol  Estrone/*analogs & derivatives. Yao Hsueh Hsueh Pao 1986;21(2):98
3-(2-iodobenzoyl)estrone  91999-14-3   Estrone/*analogs & derivatives. Int J Appl Radiat Isot 1985;36(5):379
estrone-17-oxime-bovine serum albumin  0   *Serum Albumin, Bovine Estrone/*analogs & derivatives Estrogens, Conjugated (USP). J Anim Sci 1984;59(1):189
estrone-17-nitrone  0   Estrone/*analogs & derivatives. Steriods 1983;42(1):1
estrone-17-hydroxylamine  0   Estrone/*analogs & derivatives. Steroids 1983;42(1):1
3-dansylestrone  30804-69-4 Estra-1,3,5(10)-trien-17-one, 3-(((5-(dimethylamino)-1-naphthalenyl)sulfonyl)oxy)  *Dansyl Compounds Estrone/*analogs & derivatives. J Steroid Biochem 1983;19(6):1811
percutatrine  0   *Diethylstilbestrol *Estrone *Tissue Extracts Drug Combinations Ointments. Helv Paediatr Acta 1983;38(4):361
Metharmon F  92526-19-7 Androst-4-ene-3,17-dione, mixt. with (3beta,17beta)-androst-5-ene-3,17-diol, desiccated thyroid hormones, (17beta)-17-hydroxyandrost-4-en-3-one, 3-hydroxyestra-1,3,5(10)-trien-17-one and (3beta)-3-hydroxypregn-5-en-20-one  *Androstenedione *Estrone *Pregnenolone *Testosterone *Thyroid (USP) *Androstenediol Drug Combinations. Horumon To Rinsho 1983;31(8):815
16-methylene estrone  10506-73-7 Estra-1,3,5(10)-trien-17-one, 3-hydroxy-16-methylene  Estrone/*analogs & derivatives 20-Hydroxysteroid Dehydrogenases/antagonists & inhibitors. J Biol Chem 1983;258(19):11500
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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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