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Ethacrynic Acid

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Definition: A compound that inhibits symport of sodium, potassium, and chloride primarily in the ascending limb of Henle, but also in the proximal and distal tubules. This pharmacological action results in excretion of these ions, increased urinary output, and reduction in extracellular fluid. This compound has been classified as a loop or high ceiling diuretic.     
Pharmacological Action Diuretics; Enzyme Inhibitors 		Other names Sodium, Ethacrynate; Acid, Ethacrynic; Acid, Ethacrinic; Acid, Etacrynic; Hydromedin; Ethacrynic Acid, Sodium Salt; Ethacrynate Sodium; Ethacrinic Acid; Etacrynic Acid; EdecrinDrugs* : EDECRIN
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
ethacraplatin  0   *Organoplatinum Compounds Ethacrynic Acid/*analogs & derivatives Glutathione Transferase/antagonists & inhibitors. J Am Chem Soc. 2005 Feb 9;127(5):1382-3.
ethacrynic acid glutathione thioether  0   Ethacrynic Acid/*analogs & derivatives Glutathione/*analogs & derivatives. J Pharm Biomed Anal 2010 Jan 5;51(1):164-9
SA12590  0   *Oximes Ethacrynic Acid/*analogs & derivatives. Biol Pharm Bull 2007 Aug;30(8):1445-9
SA9000  0   *Cinnamates Ethacrynic Acid/*analogs & derivatives. Biol Pharm Bull. 2004 Jul;27(7):1019-24
dihydroethacrynate  5378-94-9 (2,3-dichloro-4-(2-methyl-1-oxobutyl)phenoxy)acetic acid  Ethacrynic Acid/*analogs & derivatives. Biochemie 58(6):713;1976; Can J Physiol Pharmacol 51(9):642;1973

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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