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Ethylene Oxide

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Definition: A colorless and flammable gas at room temperature and pressure. Ethylene oxide is a bactericidal, fungicidal, and sporicidal disinfectant. It is effective against most micro-organisms, including viruses. It is used as a fumigant for foodstuffs and textiles and as an agent for the gaseous sterilization of heat-labile pharmaceutical and surgical materials. (From Reynolds, Martindale The Extra Pharmacopoeia, 30th ed, p794)     
Pharmacological Action Disinfectants 		Other names Oxide, Ethylene; Oxirane
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
(3-phenyloxirane-2,2-diyl)bis(phenylmethanone)  0   Ethylene Oxide/*analogs & derivatives. Chirality. 2010;22 Suppl 1():E130-5
1-(5-methyl-1H-pyrrol-2-yl)-2-((2S,3R)-3-((E)-prop-1-enyl)oxiran-2-yl)ethanone  0   *Pyrroles Ethylene Oxide/*analogs & derivatives. Nat Prod Commun. 2009 Nov;4(11):1489-90
2-lithio-3,3-dimethyl-2-oxazolinyloxirane  0   *Organometallic Compounds Ethylene Oxide/*analogs & derivatives. J Org Chem. 2008 Dec 19;73(24):9552-64
poly(isoprene-block-ethylene oxide)  0   *Hemiterpenes Ethylene Oxide/*analogs & derivatives Polymers. J Am Chem Soc. 2009 Jul 8;131(26):9389-95
(2S,3S)-oxirane-2,3-dicarboxylic acid 2-(((S)-1-benzylcarbamoyl-2-phenyl-ethyl)-amide) 3-((2-(4-hydroxy-phenyl)-ethyl)-amide)  0   *Benzyl Compounds Ethylene Oxide/*analogs & derivatives. Biol Pharm Bull. 2009 Mar;32(3):475-9
(ethylene oxide)13(propylene oxide)30(ethylene oxide)13  0   Ethylene Oxide/*analogs & derivatives Polymers. Phys Chem Chem Phys. 2008 Feb 14;10(6):794-9
(2S,3S)-oxirane-2,3-dicarboxylic acid  0   *Dicarboxylic Acids Ethylene Oxide/*analogs & derivatives. J Biotechnol 2007 Apr 30;129(2):308-15
viridenepoxydiol  0   *Alkenes Ethylene Oxide/*analogs & derivatives. J Agric Food Chem. 2006 Sep 6;54(18):6588-92
2-(5-methyl-5-(oxiran-2-yl)-tetrahydrofuran-2-yl)propan-1-ol  0   *Furans *Propanols Ethylene Oxide/*analogs & derivatives. Phytochemistry. 2006 Apr;67(8):759-63
(2S,3R)-2-(2Z,5Z-octadienyl)-3-nonyloxirane  0   *Fatty Acids Ethylene Oxide/*analogs & derivatives. J Agric Food Chem. 2004 May 19;52(10):2890-5
EXL596  0   *Ethylene Oxide Composite Resins. J Dent 2003 Jul;31(5):341-51
nonaoxirane  0   *Alkenes Ethylene Oxide/*analogs & derivatives. Angew Chem Int Ed Engl. 2002 Mar 1;41(5):814-7
methyl(trifluoromethyl)dioxirane  0   Ethylene Oxide/*analogs & derivatives. J Org Chem 2001 Dec 28;66(26):9063-6
(1-chloroethenyl)oxirane  0   Ethylene Oxide/*analogs & derivatives. Chem Biol Interact 2001 Jun 1;135-136:703-13
2-methylstyrene oxide  0   *Styrenes Ethylene Oxide. J Am Chem Soc 2001 Apr 11;123(14):3350-7
ethyl(methyl)dioxirane  0   Ethylene Oxide/*analogs & derivatives Indicators and Reagents. Org Lett 2001 Mar 22;3(6):815-8
PLC(20)-b-PEO(44)  0   *Ethylene Oxide *Lactones Drug Carriers Polymers. Biochim Biophys Acta 1999 Sep 21;1421(1) :32-8
3-methyl-2-nitro-1-(2,3-epoxypropoxy)benzene  67823-49-8   Ethylene Oxide/*analogs & derivatives Toluene/*analogs & derivatives. Cancer Lett 1990;55(1):61
TN detergent  55206-48-9   *Ethylene Oxide *Stearic Acids. Agents Actions 1987;20(3-4):219
tert-decanoic acid oxiranylmethyl ester  71206-09-2   *Decanoic Acids Ethylene Oxide/*analogs & derivatives. Contact Dermatitis 1984;11(3):190
2-cyanoethylene oxide  4538-51-6   Ethylene Oxide/*analogs & derivatives.
Pharma Action Carcinogens 		Cancer Res 1981;41(12):4925
1,1-bis(4-chlorophenyl)ethylene oxide  71339-08-7 Oxirane, 2,2-bis(4-chlorophenyl)  Ethylene Oxide/*analogs & derivatives. Chem Biol Interact 25(2-3):157;1979
chloroethylene oxide  7763-77-1   Ethylene Oxide/*analogs & derivatives. Biochemistry 18(23):5177;1979; Biochemistry 1979;18(23):5177; Biochim Biophys Acta 442(3):405;1976; Cancer Res 1980;40(2):352; Chem Biol Interact 17(2):239;1977

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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